From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.02
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.32
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Liver 1
Om (Mus musculus)
Om - F1760C (1) Om - I304N (1)
Pain Link Frequency Relevance Heat
lidocaine 4 97.24 Very High Very High Very High
agonist 12 84.16 Quite High
sodium channel 3 76.24 Quite High
antagonist 28 64.24 Quite High
local anesthetic 1 58.36 Quite High
anesthesia 2 57.60 Quite High
imagery 13 56.56 Quite High
Calcium channel 6 41.48 Quite Low
allodynia 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gangliosidoses 2 75.00 Quite High
Apoptosis 3 67.44 Quite High
Death 1 60.24 Quite High
Fragile X Syndrome 21 50.00 Quite Low
Sprains And Strains 4 35.68 Quite Low
Epstein-barr Virus 2 9.08 Low Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Intellectual Impairment 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While menthol decreased the gating charge of the wild-type channel, the mutant channel gating charge was unaffected.
Neg (unaffected) Negative_regulation (unaffected) of mutant
1) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.14
There was a statistically significant decrease in b/a ratios in mutant compared to wild type mice.
Negative_regulation (decrease) of mutant
2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
The I304N mutation in FMRP abrogates binding to high affinity in vitro selected KH2 target RNA ligands (kcRNA) but not RGG target (G-quartet) RNAs, as assessed with both full-length FMRP and isolated RNA binding domains [51],[64], indicating that KH-specific RNA interactions are lost in the I304N mutant in vitro.
Negative_regulation (lost) of I304N mutant (I304N)
3) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
The covalent-modifying agent MTS-ET enhanced use-dependent current reduction of the F1760C mutant channel only.
Negative_regulation (reduction) of F1760C mutant (F1760C)
4) Confidence 0.01 Published 2005 Journal J. Membr. Biol. Section Abstract Doc Link 16477531 Disease Relevance 0 Pain Relevance 0.53
Liver IGF-I messenger RNA and pituitary GH messenger RNA both were reduced significantly in GM1 mutant cats.
Negative_regulation (reduced) of GM1 mutant in Liver
5) Confidence 0.00 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579334 Disease Relevance 0.32 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools