INT85168

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Context Info
Confidence 0.02
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.32
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Liver 1
Om (Mus musculus)
Om - F1760C (1) Om - I304N (1)
Pain Link Frequency Relevance Heat
lidocaine 4 97.24 Very High Very High Very High
agonist 12 84.16 Quite High
sodium channel 3 76.24 Quite High
antagonist 28 64.24 Quite High
local anesthetic 1 58.36 Quite High
anesthesia 2 57.60 Quite High
imagery 13 56.56 Quite High
Calcium channel 6 41.48 Quite Low
allodynia 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gangliosidoses 2 75.00 Quite High
Apoptosis 3 67.44 Quite High
Death 1 60.24 Quite High
Fragile X Syndrome 21 50.00 Quite Low
Sprains And Strains 4 35.68 Quite Low
Epstein-barr Virus 2 9.08 Low Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Intellectual Impairment 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While menthol decreased the gating charge of the wild-type channel, the mutant channel gating charge was unaffected.
Neg (unaffected) Negative_regulation (unaffected) of mutant
1) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.14
There was a statistically significant decrease in b/a ratios in mutant compared to wild type mice.
Negative_regulation (decrease) of mutant
2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432030 Disease Relevance 0 Pain Relevance 0
The I304N mutation in FMRP abrogates binding to high affinity in vitro selected KH2 target RNA ligands (kcRNA) but not RGG target (G-quartet) RNAs, as assessed with both full-length FMRP and isolated RNA binding domains [51],[64], indicating that KH-specific RNA interactions are lost in the I304N mutant in vitro.
Negative_regulation (lost) of I304N mutant (I304N)
3) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
The covalent-modifying agent MTS-ET enhanced use-dependent current reduction of the F1760C mutant channel only.
Negative_regulation (reduction) of F1760C mutant (F1760C)
4) Confidence 0.01 Published 2005 Journal J. Membr. Biol. Section Abstract Doc Link 16477531 Disease Relevance 0 Pain Relevance 0.53
Liver IGF-I messenger RNA and pituitary GH messenger RNA both were reduced significantly in GM1 mutant cats.
Negative_regulation (reduced) of GM1 mutant in Liver
5) Confidence 0.00 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579334 Disease Relevance 0.32 Pain Relevance 0.06

General Comments

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