INT85178

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Context Info
Confidence 0.21
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.17
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (OAS2) mitochondrion (OAS2) endoplasmic reticulum (OAS2)
RNA binding (OAS2) nucleus (OAS2) nucleotidyltransferase activity (OAS2)
Anatomy Link Frequency
horn 2
neuronal 1
hepatocytes 1
villus 1
OAS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 99.26 Very High Very High Very High
tetrodotoxin 7 96.48 Very High Very High Very High
Inflammation 20 89.28 High High
cINOD 10 87.60 High High
Infliximab 13 82.64 Quite High
sodium channel 2 79.68 Quite High
intrathecal 5 79.20 Quite High
fibrosis 1 76.88 Quite High
Inflammatory response 8 75.44 Quite High
Pain 1 75.04 Quite High
Disease Link Frequency Relevance Heat
Shock 7 100.00 Very High Very High Very High
Adhesions 6 100.00 Very High Very High Very High
Hepatocellular Cancer 1 99.12 Very High Very High Very High
Apoptosis 23 97.56 Very High Very High Very High
Nociception 4 97.04 Very High Very High Very High
Adenocarcinoma 42 96.16 Very High Very High Very High
Death 6 95.96 Very High Very High Very High
Lifespan 1 95.64 Very High Very High Very High
Neurodegenerative Disease 4 94.88 High High
Hypoxia 3 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For three other IFN response genes (Mx2, OAS2, and SERPING1), a trend (P = approximately 0.06, data not shown) was observed toward increased expression in the poor responder patients.
Gene_expression (expression) of OAS2
1) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875639 Disease Relevance 0.19 Pain Relevance 0.17
The gene expressions of hyaluronan synthase-1, hyaluronan synthase-2, and interleukin-10 which is an antiadhesive cytokine were predominant in nonadhesive bursae.
Gene_expression (expressions) of synthase-2 associated with cytokine
2) Confidence 0.19 Published 2003 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 12838053 Disease Relevance 0.31 Pain Relevance 0.16
IL18, OAS genes) or directly involved in IFN signaling (JAK/STAT), STAT1 and OAS1, OAS2, OAS3 and MxA best distinguished the two phenotypes.


Gene_expression (signaling) of OAS2
3) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.35 Pain Relevance 0
Using Affymetrix GeneChip (HG-U133A), we have selected a subset of 692 differentially expressed genes, several of which are-cullin 4A (CUL4A), ubiquitin carrier protein (E2-EPF), proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) (PSMB8), protein tyrosine phosphatase type IVA (PTP4A1), intercellular adhesion molecule 1 (ICAM1), prostaglandin-endoperoxide synthase 2 (PTGS2), and caspase 1 (CASP1).
Gene_expression (expressed) of synthase 2 associated with adhesions
4) Confidence 0.06 Published 2004 Journal Toxicon Section Abstract Doc Link 15501285 Disease Relevance 0.83 Pain Relevance 0.69
These cells are a rich source of prostaglandin G/H synthase 2 (COX-2) and vasoactive prostaglandins (PG) and thus the ability of recombinant AKR1C enzymes to act as PGF synthases was compared.
Gene_expression (source) of synthase 2
5) Confidence 0.05 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16417966 Disease Relevance 0.52 Pain Relevance 0.05
Moreover, acyl-coenzyme A synthetase 5, which is solely expressed at the villus tip, is able to sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL [38].
Gene_expression (expressed) of synthetase 5 in villus associated with apoptosis and death
6) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.80 Pain Relevance 0
Nitric oxide (NO) and its synthesizing enzymes, including NO synthase-2 (NOS-2, also called inducible NOS, iNOS), have been implicated in spinal nociception. 1400W is a highly selective NOS-2 inhibitor, as compared with either NOS-1 (neuronal NOS, nNOS) or NOS-3 (endothelial NOS).
Gene_expression (synthesizing) of NO synthase-2 in neuronal associated with nociception
7) Confidence 0.01 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17561811 Disease Relevance 0.48 Pain Relevance 0.29
Stimulation of fetal hepatocytes with proinflammatory cytokines and lipopolysaccharide promotes the expression of cyclooxygenase-2 (COX-2) and nitric oxide synthase-2 (NOS-2), whereas the hepatoma cell line HepG2 exhibits a behavior similar to that described for adult hepatocytes and only expresses NOS-2.
Gene_expression (expression) of synthase-2 in hepatocytes associated with hepatocellular cancer and cytokine
8) Confidence 0.00 Published 2002 Journal Hepatology Section Abstract Doc Link 11826407 Disease Relevance 0.34 Pain Relevance 0.43
Differential expression of myometrial oxytocin receptor and prostaglandin H synthase 2, but not estrogen receptor alpha and heat shock protein 90 messenger ribonucleic acid in the gravid horn and nongravid horn in sheep during betamethasone-induced labor.
Gene_expression (expression) of synthase 2 in horn associated with shock
9) Confidence 0.00 Published 1999 Journal Endocrinology Section Title Doc Link 10579336 Disease Relevance 0.18 Pain Relevance 0.06
In the present study, we characterized four myometrial contraction-associated proteins (mCAPs): oxytocin receptor (OTR), prostaglandin H synthase 2 (PGHS2), estrogen receptor alpha (ERalpha), and heat shock protein 90 (Hsp90) messenger RNA (mRNA) expression in the nongravid horn of pregnant sheep and compared them with their expression in the gravid horn that is exposed to a greater degree of stretch.
Gene_expression (expression) of synthase 2 in horn associated with shock
10) Confidence 0.00 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579336 Disease Relevance 0.17 Pain Relevance 0.06

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