INT8518

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1989
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 53
Total Number 56
Disease Relevance 36.68
Pain Relevance 24.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
T cell 9
MNC 5
lymphocyte 4
lymph node 3
spleen 3
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 70 100.00 Very High Very High Very High
cytokine 33 100.00 Very High Very High Very High
Neuritis 169 99.90 Very High Very High Very High
cINOD 3 99.72 Very High Very High Very High
Peripheral nervous system 22 99.64 Very High Very High Very High
Spinal cord 38 99.60 Very High Very High Very High
Dorsal horn 35 99.28 Very High Very High Very High
Hyperalgesia 7 98.98 Very High Very High Very High
dexamethasone 8 98.78 Very High Very High Very High
Multiple sclerosis 59 98.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 71 100.00 Very High Very High Very High
Optic Neuritis 46 99.90 Very High Very High Very High
Disease 30 99.84 Very High Very High Very High
Cancer 9 99.28 Very High Very High Very High
Necrosis 13 99.04 Very High Very High Very High
Hyperalgesia 9 98.98 Very High Very High Very High
Experimental Autoimmune Neuritis 122 98.68 Very High Very High Very High
Demyelinating Disease 74 98.58 Very High Very High Very High
Mumps 10 98.48 Very High Very High Very High
Pain 12 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, IFN-gamma released in the CNS may participate in eliciting pain and hyperalgesia in infectious or neuroinflammatory diseases where there is increased production of this cytokine.
Localization (released) of IFN-gamma associated with pain, hyperalgesia, disease and cytokine
1) Confidence 0.81 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7715823 Disease Relevance 0.53 Pain Relevance 0.44
In contrast to its protective systemic effect in the mouse, constitutive secretion of IFN-gamma in the rat eye was found to predispose the development of severe anterior uveitis and induction of retinal degenerative processes that impair visual acuity.
Localization (secretion) of IFN-gamma in anterior associated with uveitis
2) Confidence 0.80 Published 1999 Journal Clin. Immunol. Section Abstract Doc Link 10227812 Disease Relevance 1.35 Pain Relevance 0.18
The aim of the present study was to examine the cellular localization and origin of the IFN-gamma R in the spinal cord.
Spec (examine) Localization (localization) of IFN-gamma in spinal cord associated with spinal cord
3) Confidence 0.78 Published 1998 Journal J. Neurocytol. Section Abstract Doc Link 10640190 Disease Relevance 0.17 Pain Relevance 0.35
Our results, showing localization of IFN-gamma R to pre- and postsynaptic sites in the dorsal horn and lateral spinal nucleus indicate that IFN-gamma can modulate nociception at the spinal cord level.
Localization (localization) of IFN-gamma in dorsal horn associated with nociception, dorsal horn and spinal cord
4) Confidence 0.78 Published 1998 Journal J. Neurocytol. Section Abstract Doc Link 10640190 Disease Relevance 0.10 Pain Relevance 0.45
The localization of the IFN-gamma R in the spinal cord differed from that of the AMPA glutamate receptor subunits 2 and 3 and the substance P receptor (NK1).
Localization (localization) of IFN-gamma in spinal cord associated with glutamate receptor, substance p and spinal cord
5) Confidence 0.78 Published 1998 Journal J. Neurocytol. Section Abstract Doc Link 10640190 Disease Relevance 0 Pain Relevance 0.48
There was no co-localization of the IFN-gamma R with markers for astrocytes and microglial cells.
Localization (localization) of IFN-gamma in astrocytes
6) Confidence 0.78 Published 1998 Journal J. Neurocytol. Section Abstract Doc Link 10640190 Disease Relevance 0.14 Pain Relevance 0.39
The localization of gamma-IFN in nerve roots indicates an important role of this lymphokine in acute immune-mediated demyelination. gamma-Interferon most likely locally affects macrophage functions such as migration, major histocompatibility complex (MHC) class II antigen (Ia) expression, and production of cytotoxic molecules in nerves, and thereby contributes to myelin damage.
Localization (localization) of gamma-IFN associated with demyelination
7) Confidence 0.73 Published 1992 Journal Brain Section Abstract Doc Link 1486454 Disease Relevance 0.79 Pain Relevance 0.21
In the present experiments, we found that: (1) selective inhibition of glia metabolism with intrathecal (i.t.) administration of fluorocitrate (1 nmol) results in a marked, but reversible, attenuation of the persistent thermal and mechanical hyperalgesia produced by intraplantar zymosan (5 mg); (2) selective inhibition of the inducible form of nitric oxide synthase (iNOS) with i.t. aminoguanidine (1 pmol-1 nmol) resulted in a dose-dependent inhibition of the persistent thermal, but not mechanical hyperalgesia produced by intraplantar zymosan (5 mg); (3) i.t. coadministration of interleukin 1 beta (IL1 beta; 10 ng) and interferon gamma (IFN; 1000 U) resulted in expression of the message for iNOS 8 hr after administration assessed using reverse-transcription polymerase chain reaction (RT-PCR) and Southern blot analysis; and (4) i.t. administration of lipopolysaccharide (LPS; 150 micrograms) produced a time-dependent thermal hyperalgesia compared with saline treated-rats (15 microliters).
Localization (coadministration) of interferon gamma associated with hyperalgesia, thermal hyperalgesia and intrathecal
8) Confidence 0.73 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7532831 Disease Relevance 0.71 Pain Relevance 0.64
In the IFN-gamma secretion assay zimeldine, CPP 200, clomipramine and maprotiline all in a concentration-dependent mode reduced the number of IFN-gamma secreting cells while norzimeldine and imipramine did not affect the IFN-gamma secretion.
Localization (ecretion.) of IFN-gamma
9) Confidence 0.72 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1535634 Disease Relevance 0.40 Pain Relevance 0.49
The action of several drugs on induced T cell secretion of IFN-gamma suggests that the mechanisms for the suppressive effect of zimeldine and norzimeldine on EAN symptoms can be due to an action on myelin T cell autoreactivity.
Localization (ecretion ) of IFN-gamma in T cell associated with neuritis
10) Confidence 0.72 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1535634 Disease Relevance 0.28 Pain Relevance 0.37
As viewed by confocal microscopy, the immunopositivity for the IFN-gamma R was co-localized with that of the presynaptic marker synaptophysin and with neuronal nitric oxide synthase in the lateral spinal nucleus, whereas only a minor overlap with these molecules was observed in laminae I and II of the dorsal horn.
Localization (localized) of IFN-gamma in neuronal associated with dorsal horn and neuronal nitric oxide synthase
11) Confidence 0.69 Published 1998 Journal J. Neurocytol. Section Abstract Doc Link 10640190 Disease Relevance 0.16 Pain Relevance 0.35
This study reports the cellular localization of gamma-interferon (gamma-IFN) in nerve roots during the course of experimental autoimmune neuritis induced either by active immunization (EAN) or adoptive transfer of P2-specific T-cells (AT-EAN).
Localization (localization) of gamma-interferon in T-cells associated with experimental autoimmune neuritis, immunization and neuritis
12) Confidence 0.69 Published 1992 Journal Brain Section Abstract Doc Link 1486454 Disease Relevance 0.81 Pain Relevance 0.20
This study reports the cellular localization of gamma-interferon (gamma-IFN) in nerve roots during the course of experimental autoimmune neuritis induced either by active immunization (EAN) or adoptive transfer of P2-specific T-cells (AT-EAN).
Localization (localization) of gamma-IFN in T-cells associated with experimental autoimmune neuritis, immunization and neuritis
13) Confidence 0.69 Published 1992 Journal Brain Section Abstract Doc Link 1486454 Disease Relevance 0.82 Pain Relevance 0.20
We identified and refined a total of five quantitative trait loci on rat chromosomes 4, 10, and 12 (RNO4, RNO10, RNO12), showing linkage to splenic IFN-gamma secretion and disease severity.
Localization (ecretion ) of IFN-gamma associated with disease
14) Confidence 0.68 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19299744 Disease Relevance 0.98 Pain Relevance 0.32
The beneficial effects were associated with profound modifications of the capacity of these rats to produce and release pro- and anti-inflammatory cytokines such as IFN-gamma, TNF-alpha and IL-10, which are important in regulating the development of EAN.
Localization (release) of IFN-gamma associated with inflammation, neuritis and cytokine
15) Confidence 0.68 Published 1999 Journal J. Autoimmun. Section Abstract Doc Link 10479387 Disease Relevance 0.87 Pain Relevance 0.45
All the monoamine reuptake inhibiting antidepressants tested in this study showed immunomodulatory effects by either a reduction of the number of IFN-gamma-secreting cells or the MNC proliferation.
Localization (secreting) of IFN-gamma in MNC associated with antidepressant and monoamine
16) Confidence 0.68 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1535634 Disease Relevance 0.17 Pain Relevance 0.33
In the IFN-gamma secretion assay zimeldine, CPP 200, clomipramine and maprotiline all in a concentration-dependent mode reduced the number of IFN-gamma secreting cells while norzimeldine and imipramine did not affect the IFN-gamma secretion.
Localization (secreting) of IFN-gamma
17) Confidence 0.68 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1535634 Disease Relevance 0.41 Pain Relevance 0.49
In the IFN-gamma secretion assay zimeldine, CPP 200, clomipramine and maprotiline all in a concentration-dependent mode reduced the number of IFN-gamma secreting cells while norzimeldine and imipramine did not affect the IFN-gamma secretion.
Localization (secretion) of IFN-gamma
18) Confidence 0.68 Published 1992 Journal J. Neuroimmunol. Section Abstract Doc Link 1535634 Disease Relevance 0.42 Pain Relevance 0.45
RESULTS: Rats treated with DHEA at different doses displayed significant decreases in numbers of IFN-gamma, TNF-alpha expressing cells in the PNS (P<0.05), BPM-stimulated T cell proliferation (P<0.05), IFN-gamma, TNF-alpha secretion in draining lymph node and spleen (P<0.05) compared to control group.
Localization (secretion) of IFN-gamma in spleen
19) Confidence 0.67 Published 2008 Journal Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Section Body Doc Link 20104686 Disease Relevance 0.07 Pain Relevance 0
We studied the T cell responses to these proteins and the glycolipid GM1 by enumerating T helper type 1 (Th1)-like cells secreting interferon-gamma (IFN-gamma) after short-term culture of mononuclear cells (MNC) in presence of antigen.
Localization (ecreting ) of IFN-gamma in MNC
20) Confidence 0.62 Published 1994 Journal Acta Neurol. Scand. Section Abstract Doc Link 7524259 Disease Relevance 1.02 Pain Relevance 0.73

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox