INT85214

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 24
Total Number 27
Disease Relevance 4.05
Pain Relevance 12.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCN11A) transmembrane transport (SCN11A)
Anatomy Link Frequency
spine 3
dorsal root ganglion 3
flagellum 1
central nervous system 1
small intestine 1
SCN11A (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 144 100.00 Very High Very High Very High
sodium channel 90 100.00 Very High Very High Very High
tetrodotoxin 71 100.00 Very High Very High Very High
Nav1.9 8 100.00 Very High Very High Very High
nav1.8 18 99.78 Very High Very High Very High
Central nervous system 11 99.68 Very High Very High Very High
Nav1.7 14 99.28 Very High Very High Very High
Nav1.6 14 98.80 Very High Very High Very High
dorsal root ganglion 1 98.76 Very High Very High Very High
Neuropeptide 14 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 5 99.92 Very High Very High Very High
Rheumatoid Arthritis 138 99.76 Very High Very High Very High
Neuroma 4 99.76 Very High Very High Very High
Ganglion Cysts 2 98.28 Very High Very High Very High
Injury 9 93.92 High High
Neuropathic Pain 3 93.52 High High
Hypersensitivity 2 92.24 High High
Low Back Pain 4 90.88 High High
Nervous System Injury 2 90.64 High High
Targeted Disruption 9 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although expression level could not be determined, SCN12A is also expressed in dorsal root ganglia (DRG).
Gene_expression (expressed) of SCN12A in dorsal root ganglia
1) Confidence 0.78 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.65
Both neurons and glial cells express SCN12A.
Gene_expression (express) of SCN12A in glial cells
2) Confidence 0.78 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.65
These results suggest that SCN12A is a tetrodotoxin-resistant (TTX-R) sodium channel expressed in the central nervous system and nonneural tissues.
Gene_expression (expressed) of SCN12A in central nervous system associated with tetrodotoxin, sodium channel and central nervous system
3) Confidence 0.78 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.66
SCN12A is expressed predominantly in olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine, and placenta.
Gene_expression (expressed) of SCN12A in cerebellar cortex associated with hippocampus and spinal cord
4) Confidence 0.78 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.63
The tetrodotoxin-resistant (TTX-R) voltage-gated sodium channel SNS/PN3 and the newly discovered NaN/SNS2 are expressed in sensory neurones, particularly in nociceptors.
Gene_expression (expressed) of NaN in nociceptors associated with tetrodotoxin, nociceptor and sodium channel
5) Confidence 0.75 Published 2000 Journal Pain Section Abstract Doc Link 10692601 Disease Relevance 0.23 Pain Relevance 0.47
The voltage-gated sodium channels SNS/PN3 and NaN/SNS2 are expressed by sensory neurone that mediate pain, but their presence in the lumbar spine is unknown.
Gene_expression (expressed) of NaN in spine
6) Confidence 0.75 Published 2002 Journal Spine Section Body Doc Link 11805657 Disease Relevance 0.15 Pain Relevance 0
subunits SCN1A (Nav1.1, 225 bp), SCN2A (Nav1.2, 297 bp), SCN3A (Nav1.3, 367 bp), SCN4A (Nav1.4, 317 bp), SCN5A (Nav1.5, 294 bp), SCN8A (Nav1.6, 207 bp), SCN9A (Nav1.7, 289 bp), SCN10A (Nav1.8, 347 bp), SCN11A (Nav1.9, 272 bp) and the related isoform SCN7A (Nax, 327 bp) were all expressed in human sperm cDNA (Fig 1).
Gene_expression (expressed) of SCN11A in sperm associated with nav1.3, nav1.1, nav1.2, nav1.8, nav1.7, nav1.6 and nav1.9
7) Confidence 0.74 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.97
SCN11A (Nav1.9) was present over the acrosomal region of the head and in the flagellum midpiece.
Gene_expression (present) of SCN11A in flagellum associated with nav1.9
8) Confidence 0.74 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.90
OBJECTIVES: To demonstrate the presence of nerve fibers in lumbar spine structures and spine nerve roots, and to determine whether they express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2.
Spec (whether) Gene_expression (express) of NaN in spine
9) Confidence 0.65 Published 2002 Journal Spine Section Body Doc Link 11805657 Disease Relevance 0.18 Pain Relevance 0
The distribution of SNS/PN3 and SNS2/NaN sodium channels in injured human nerves indicates that they represent targets for novel analgesics, and could account for some differences in the development of neuropathic pain in infants.
Gene_expression (distribution) of NaN in nerves associated with analgesic, neuropathic pain and sodium channel
10) Confidence 0.65 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 10675548 Disease Relevance 0.71 Pain Relevance 0.43
Nerve fibers in lumbar spine structures and injured spinal roots express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2.
Gene_expression (express) of NaN in sensory neuron associated with neuropeptide and sodium channel
11) Confidence 0.65 Published 2002 Journal Spine Section Title Doc Link 11805657 Disease Relevance 0 Pain Relevance 0.24
The voltage-gated sodium channels SNS/PN3 and NaN/SNS2 are expressed by sensory neurone that mediate pain, but their presence in the lumbar spine is unknown.
Gene_expression (expressed) of SNS2 in spine
12) Confidence 0.58 Published 2002 Journal Spine Section Body Doc Link 11805657 Disease Relevance 0.15 Pain Relevance 0
NaN is a recently described tetrodotoxin-resistant sodium channel expressed preferentially in IB4-labeled dorsal root ganglion (DRG) neurons.
Gene_expression (expressed) of NaN in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, tetrodotoxin and sodium channel
13) Confidence 0.58 Published 2000 Journal Neuroreport Section Abstract Doc Link 10683857 Disease Relevance 0.20 Pain Relevance 0.66
Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal ganglia neurons, most of which are nociceptive, of rat and mouse.
Gene_expression (expressed) of NaN in DRG associated with nociception, tetrodotoxin and sodium channel
14) Confidence 0.43 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10580103 Disease Relevance 0.17 Pain Relevance 0.30
SCN12A is expressed predominantly in olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine, and placenta.
Gene_expression (expressed) of SCN12A in olfactory bulb associated with hippocampus and spinal cord
15) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.63
SCN12A is expressed predominantly in olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine, and placenta.
Gene_expression (expressed) of SCN12A in hippocampus associated with hippocampus and spinal cord
16) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.63
SCN12A is expressed predominantly in olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine, and placenta.
Gene_expression (expressed) of SCN12A in spleen associated with hippocampus and spinal cord
17) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.63
SCN12A is expressed predominantly in olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine, and placenta.
Gene_expression (expressed) of SCN12A in small intestine associated with hippocampus and spinal cord
18) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.63
SCN12A is expressed predominantly in olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine, and placenta.
Gene_expression (expressed) of SCN12A in spinal cord associated with hippocampus and spinal cord
19) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.63
SCN12A is expressed predominantly in olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine, and placenta.
Gene_expression (expressed) of SCN12A in placenta associated with hippocampus and spinal cord
20) Confidence 0.26 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10623608 Disease Relevance 0 Pain Relevance 0.63

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox