INT85233

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 10.91
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SGSM3) cell cycle (SGSM3) cytoplasm (SGSM3)
Anatomy Link Frequency
plasma 1
brain 1
neutrophils 1
SGSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 544 99.80 Very High Very High Very High
Kinase C 1 99.20 Very High Very High Very High
Nerve growth factor 4 97.70 Very High Very High Very High
Crohn's disease 24 96.88 Very High Very High Very High
Hsan 6 96.76 Very High Very High Very High
cINOD 16 94.12 High High
Deep tissue 5 85.68 High High
COX-2 inhibitor 1 79.52 Quite High
Opioid 2 79.12 Quite High
Neuropeptide 1 76.96 Quite High
Disease Link Frequency Relevance Heat
Paratuberculosis 240 100.00 Very High Very High Very High
Sleep Disorders 12 100.00 Very High Very High Very High
Cv General 3 Under Development 532 99.80 Very High Very High Very High
Diabetes Mellitus 261 98.00 Very High Very High Very High
Disease 56 96.88 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 6 96.76 Very High Very High Very High
Hyperkinesis 4 95.84 Very High Very High Very High
Infection 24 93.36 High High
Hypoxia 5 91.60 High High
Pressure Volume 2 Under Development 21 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis and immunocytochemistry revealed that H2O2 treatment elicited the phosphorylation and nuclear translocation of ERK 1/2 and p38 MAP kinases.
Localization (translocation) of MAP
1) Confidence 0.78 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595755 Disease Relevance 0.52 Pain Relevance 0.20
We also show that this action involves inhibition of mitogen-activated protein (MAP) kinase (ERK2) activity, interference with ERK nuclear translocation, is independent of protein kinase C and has prostaglandin-dependent and prostaglandin-independent components.
Localization (translocation) of MAP associated with kinase c
2) Confidence 0.73 Published 1999 Journal Nat. Med. Section Abstract Doc Link 10581086 Disease Relevance 1.10 Pain Relevance 0.77
Although NGF alone did not exert a chemotactic effect, its presence enhanced both migration toward fMLP and phosphorylation of MAP kinases (ERK and JNK) in neutrophils from healthy controls, but not in neutrophils from CIPA patients.
Localization (kinases) of MAP in neutrophils associated with nerve growth factor and hsan
3) Confidence 0.73 Published 2009 Journal Clin. Immunol. Section Abstract Doc Link 18955016 Disease Relevance 0.67 Pain Relevance 0.71
When there is no relationship between MAP and ICP, increasing MAP typically will not increase ICP [15,22,23] Thus, when the CAP Index is increased and ICP cannot be reduced, increasing MAP may improve CPP.
Neg (no) Localization (relationship) of MAP associated with cva
4) Confidence 0.09 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.26 Pain Relevance 0.50
When the CAP Index is >0.25 (n = 365; MAP - 91.0 ± 12.0; ICP - 27.1 ± 9.1; CPP - 64.0 ± 14.6), there is no relationship between MAP and ICP (r = 0.07; p = 0.16)

Discussion

Neg (no) Localization (relationship) of MAP associated with cva
5) Confidence 0.09 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.28 Pain Relevance 0.56
Primary interventions for patients with ICP >20 torr included: brain CT scan to detect surgical lesions and the need for craniotomy, sedation when MAP ?
Localization (sedation) of MAP in brain associated with cva and sleep disorders
6) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.04 Pain Relevance 0.18
When there is no relationship between MAP and ICP, increasing MAP typically will not increase ICP [15,22,23] Thus, when the CAP Index is increased and ICP cannot be reduced, increasing MAP may improve CPP.
Localization (improve) of MAP associated with cva
7) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.14 Pain Relevance 0.42
Detection of MAP by MptD-peptide and fMptD based immuno assays in T1DM and T2DM cases and controls
Localization (Detection) of MAP associated with diabetes mellitus and paratuberculosis
8) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.55 Pain Relevance 0.03
Infected domestic animals such as sheep and cattle excrete huge numbers of MAP into the environment where their survival and persistence particularly within the protists is well established [1], [19].
Localization (excrete) of MAP associated with paratuberculosis
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.14 Pain Relevance 0.05
Isolation of MAP after plasma inoculation into Mycobacterial selective media
Localization (Isolation) of MAP in plasma associated with paratuberculosis
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 0.91 Pain Relevance 0
Co-localization of cPLA2 and MAP kinases has been shown in lipid bodies of human leukemic U937 cells, thereby emphasizing the regulatory function of MAP kinases for cPLA2?
Localization (localization) of MAP
11) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.29 Pain Relevance 0

General Comments

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