INT8524

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2007
Negated 5
Speculated 3
Reported most in Abstract
Documents 20
Total Number 24
Disease Relevance 5.47
Pain Relevance 9.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
striatum 11
brain 6
hippocampus 4
nucleus accumbens 4
dentate gyrus 2
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 43 100.00 Very High Very High Very High
Morphine 30 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
Dynorphin 16 100.00 Very High Very High Very High
Nucleus accumbens 22 99.68 Very High Very High Very High
Hippocampus 15 99.68 Very High Very High Very High
Raphe 4 99.68 Very High Very High Very High
addiction 4 99.56 Very High Very High Very High
Kinase C 3 99.48 Very High Very High Very High
tolerance 4 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 12 99.98 Very High Very High Very High
Diabetes Mellitus 12 99.68 Very High Very High Very High
Convulsion 10 99.40 Very High Very High Very High
Catalepsy 6 99.02 Very High Very High Very High
Eating Disorder 12 98.96 Very High Very High Very High
Dyskinesias 3 96.84 Very High Very High Very High
Targeted Disruption 1 95.84 Very High Very High Very High
Partial Seizures 3 94.56 High High
Disease 2 85.80 High High
Urological Neuroanatomy 2 81.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to determine whether (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid (ACPT-1), an agonist of group III mGluRs, injected bilaterally into the globus pallidus (GP), striatum or substantia nigra pars reticulata (SNr), can attenuate the haloperidol-induced catalepsy in rats, and whether that effect was related to modulation of proenkephalin (PENK) or prodynorphin (PDYN) mRNA expression in the striatum.
Regulation (modulation) of Transcription (expression) of PDYN in striatum associated with catalepsy, substantia nigra and agonist
1) Confidence 0.60 Published 2007 Journal Neuroscience Section Abstract Doc Link 17224239 Disease Relevance 0.42 Pain Relevance 0.17
In order to elucidate the activity of the endogenous prodynorphin system during opiate tolerance and dependence, we investigated the effect of single and repeated morphine administration on the alpha-neoendorphin tissue level, its in vitro release, and the prodynorphin messenger RNA level in the nucleus accumbens and striatum of the rat.
Spec (investigated) Regulation (effect) of Transcription (level) of prodynorphin messenger RNA in striatum associated with nucleus accumbens, addiction, tolerance, opiate and morphine
2) Confidence 0.45 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.08
In the present study, involvement of Fos in the mechanism of the PENK and PDYN gene induction in the hippocampal dentate gyrus during seizures elicited by kainic acid was studied using a knock-down technique.
Regulation (involvement) of Transcription (mechanism) of PDYN gene in dentate gyrus associated with targeted disruption and convulsion
3) Confidence 0.45 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555037 Disease Relevance 0.35 Pain Relevance 0.07
The aim of the present study was to determine whether (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid (ACPT-1), an agonist of group III mGluRs, injected bilaterally into the globus pallidus (GP), striatum or substantia nigra pars reticulata (SNr), can attenuate the haloperidol-induced catalepsy in rats, and whether that effect was related to modulation of proenkephalin (PENK) or prodynorphin (PDYN) mRNA expression in the striatum.
Regulation (modulation) of Transcription (expression) of prodynorphin in striatum associated with catalepsy, substantia nigra and agonist
4) Confidence 0.44 Published 2007 Journal Neuroscience Section Abstract Doc Link 17224239 Disease Relevance 0.42 Pain Relevance 0.17
AIM: To study that l-stepholidine (SPD) regulates the expression of proenkephalin (PENK) and prodynorphin (PDYN) mRNA and Fos in the striatum after rotational test in the 6-hydroxydopamine (6-OHDA)-lesioned rats.
Regulation (regulates) of Transcription (expression) of prodynorphin in striatum
5) Confidence 0.44 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11501038 Disease Relevance 0 Pain Relevance 0
AIM: To study that l-stepholidine (SPD) regulates the expression of proenkephalin (PENK) and prodynorphin (PDYN) mRNA and Fos in the striatum after rotational test in the 6-hydroxydopamine (6-OHDA)-lesioned rats.
Regulation (regulates) of Transcription (expression) of PDYN in striatum
6) Confidence 0.44 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11501038 Disease Relevance 0 Pain Relevance 0
The effect of L-arginine (L-ARG), a nitric oxide donor, or Nomega-nitro-L-arginine (L-NAME), a nitric oxide synthase inhibitor, on the regulation of kainic acid (KA)-induced proenkephalin (proENK) and prodynorphin (proDYN) mRNA expressions in rat hippocampus was studied.
Regulation (regulation) of Transcription (expressions) of prodynorphin in hippocampus associated with hippocampus
7) Confidence 0.44 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
The effect of cycloheximide (CHX), a protein synthesis inhibitor, on the regulation of proenkephalin (proENK) and prodynorphin (proDYN) mRNA levels, proto-oncogenes, such as c-fos, 35-kDa fra and c-jun mRNA, and the levels of their products induced by kainic acid (KA) in rat hippocampus was studied.
Regulation (regulation) of Transcription (levels) of prodynorphin in hippocampus associated with hippocampus
8) Confidence 0.44 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.08
The PDYN mRNA level in the intermediate lobe and the alpha-neoendorphin level in the neurointermediate lobe were unchanged after ethanol, as well as during the withdrawal period.
Neg (unchanged) Regulation (unchanged) of Transcription (level) of PDYN mRNA in lobe associated with withdrawal
9) Confidence 0.42 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 7969792 Disease Relevance 0 Pain Relevance 0.25
The regulation of prodynorphin (proDYN) mRNA levels by cAMP and protein kinase C (PKC) pathways was studied in cultured rat spinal cord cells.
Regulation (regulation) of Transcription (levels) of prodynorphin in spinal cord associated with kinase c and spinal cord
10) Confidence 0.35 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.27
Region-specific changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures.
Regulation (changes) of Transcription (levels) of prodynorphin associated with convulsion, dynorphin and enkephalin
11) Confidence 0.27 Published 1999 Journal J. Mol. Neurosci. Section Title Doc Link 10691294 Disease Relevance 0.74 Pain Relevance 0.60
In contrast, proenkephalin and prodynorphin messenger RNA levels were unchanged in animals which exhibited an incomplete loss of striatal dopamine uptake sites.
Neg (unchanged) Regulation (unchanged) of Transcription (levels) of prodynorphin associated with dopamine
12) Confidence 0.26 Published 1993 Journal Neuroscience Section Abstract Doc Link 8232904 Disease Relevance 0 Pain Relevance 0.87
Perforant path stimulation differentially alters prodynorphin mRNA and proenkephalin mRNA levels in the entorhinal cortex-hippocampal region.
Regulation (alters) of Transcription (levels) of prodynorphin in cortex associated with enkephalin
13) Confidence 0.26 Published 1990 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1970844 Disease Relevance 0.09 Pain Relevance 0.58
Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in rat brain.
Regulation (alter) of Transcription (levels) of prodynorphin in brain associated with shock and enkephalin
14) Confidence 0.26 Published 1989 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 2770451 Disease Relevance 0.90 Pain Relevance 0.39
Regulation of striatal prodynorphin mRNA levels by the raphe-striatal pathway.
Regulation (Regulation) of Transcription (levels) of prodynorphin associated with enkephalin and raphe
15) Confidence 0.26 Published 1988 Journal Brain Res. Section Title Doc Link 3179742 Disease Relevance 0 Pain Relevance 0.48
Chronic food restriction and streptozotocin-induced diabetes differentially alter prodynorphin mRNA levels in rat brain regions.
Regulation (alter) of Transcription (levels) of prodynorphin in brain associated with diabetes mellitus, enkephalin and eating disorder
16) Confidence 0.23 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9191075 Disease Relevance 0.70 Pain Relevance 0.36
Neither treatment altered prodynorphin mRNA levels in the caudate nucleus, nucleus accumbens or bed nucleus of the stria terminalis.
Neg (Neither) Regulation (altered) of Transcription (levels) of prodynorphin in nucleus accumbens associated with nucleus accumbens
17) Confidence 0.20 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191075 Disease Relevance 0.57 Pain Relevance 0.36
In order to elucidate the activity of the endogenous prodynorphin system during opiate tolerance and dependence, we investigated the effect of single and repeated morphine administration on the alpha-neoendorphin tissue level, its in vitro release, and the prodynorphin messenger RNA level in the nucleus accumbens and striatum of the rat.
Spec (investigated) Regulation (effect) of in nucleus accumbens Transcription (level) of prodynorphin messenger RNA in striatum associated with nucleus accumbens, addiction, tolerance, opiate and morphine
18) Confidence 0.15 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.08
We determined the effects of morphine on mRNA levels for the opioid ligands preprodynorphin (PPD) and preproenkephalin (PPE) and the kappa opioid receptor (KOR).
Spec (determined) Regulation (effects) of Transcription (levels) of opioid ligands preprodynorphin associated with kappa opioid receptor, opioid and morphine
19) Confidence 0.13 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10095091 Disease Relevance 0 Pain Relevance 0.68
Neither treatment altered prodynorphin mRNA levels in the caudate nucleus, nucleus accumbens or bed nucleus of the stria terminalis.
Neg (Neither) Regulation (altered) of in caudate nucleus Transcription (levels) of prodynorphin in nucleus accumbens associated with nucleus accumbens
20) Confidence 0.07 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191075 Disease Relevance 0.57 Pain Relevance 0.36

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