INT8525

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2009
Negated 5
Speculated 2
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 4.04
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
striatum 4
brain 2
amygdala 2
PFC 2
hippocampus 2
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 11 100.00 Very High Very High Very High
antagonist 7 100.00 Very High Very High Very High
Locus ceruleus 6 100.00 Very High Very High Very High
Cannabinoid 11 99.84 Very High Very High Very High
Enkephalin 10 99.64 Very High Very High Very High
unmyelinated 2 99.56 Very High Very High Very High
amygdala 9 99.14 Very High Very High Very High
agonist 11 98.64 Very High Very High Very High
dexamethasone 1 97.84 Very High Very High Very High
Hippocampus 4 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 6 99.50 Very High Very High Very High
Parkinson's Disease 12 99.20 Very High Very High Very High
Nociception 6 92.52 High High
INFLAMMATION 7 91.48 High High
Disease 8 89.04 High High
Pain 9 88.64 High High
Pressure And Volume Under Development 1 84.36 Quite High
Hyperalgesia 3 83.96 Quite High
Neuropathic Pain 2 81.56 Quite High
Convulsion 1 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-treatment of mice with dexamethasone, in a schedule which suppressed acute-phase gene expression after brain irradiation, did not significantly change c-fos and junB induction.
Neg (not) Regulation (change) of Neg (not) Positive_regulation (induction) of c-fos in brain associated with dexamethasone
1) Confidence 0.60 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332719 Disease Relevance 0.07 Pain Relevance 0.18
The aim of the study was to determine whether the haloperidol-produced induction of the c-fos gene in the mouse striatum is the cause of the increased expression of the striatal proenkephalin (PENK) gene after repeated haloperidol administration.
Spec (whether) Regulation (cause) of Spec (whether) Positive_regulation (induction) of c-fos gene in striatum
2) Confidence 0.45 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750842 Disease Relevance 0 Pain Relevance 0
Dopaminergic control of gene transcription during striatal ontogeny: c-fos induction by D1 receptor activation in the developing striosomes.
Regulation (control) of Positive_regulation (induction) of c-fos
3) Confidence 0.44 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.23
The induction of the immediate early gene c-fos by the dopamine D2 receptor antagonist haloperidol was not altered, while the selective D1 receptor agonist SKF 38393 failed to induce c-fos in the striatum of MPTP-treated mice.
Neg (not) Regulation (altered) of Positive_regulation (induction) of c-fos in striatum associated with parkinson's disease, dopamine, antagonist and agonist
4) Confidence 0.44 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Abstract Doc Link 8527000 Disease Relevance 0.64 Pain Relevance 0.39
Fos family member changes in nucleus caudalis neurons after primary afferent stimulation: enhancement of fos B and c-fos.
Regulation (changes) of in nucleus Positive_regulation (enhancement) of fos in neurons associated with enkephalin
5) Confidence 0.34 Published 1993 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8381898 Disease Relevance 0.06 Pain Relevance 0.25
This BV-induced Fos increase in the LC was not affected by RTX pretreatment.
Neg (not) Regulation (affected) of Positive_regulation (increase) of Fos associated with locus ceruleus
6) Confidence 0.27 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16621078 Disease Relevance 0.21 Pain Relevance 0.88
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Spec (examined) Regulation (effect) of Spec (examined) Positive_regulation (increase) of Fos in hippocampus associated with hippocampus
7) Confidence 0.23 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.23
The results indicated that 5-HT2 receptor activities participate minimally in Fos induction by fluvoxamine in the PFC and BL.
Regulation (participate) of Positive_regulation (induction) of Fos in PFC
8) Confidence 0.23 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18817806 Disease Relevance 1.14 Pain Relevance 1.05
In the basolateral (BLA) and medial amygdala, restraint stress produced a low level of Fos induction, which was unaffected by cannabinoid treatment.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (induction) of Fos in amygdala associated with stress, cannabinoid and amygdala
9) Confidence 0.20 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15280883 Disease Relevance 0.50 Pain Relevance 0.96
The expression of proenkephalin and prodynorphin genes and the induction of c-fos gene by dopaminergic drugs are not altered in the straitum of MPTP-treated mice.
Neg (not) Regulation (altered) of Positive_regulation (induction) of c-fos gene associated with parkinson's disease and enkephalin
10) Confidence 0.12 Published 1995 Journal J Neural Transm Park Dis Dement Sect Section Title Doc Link 8527000 Disease Relevance 0.58 Pain Relevance 0.48
The data indicate that input from small-diameter unmyelinated primary afferents is important for the stimulus-induced increase in Fos-LI and PPD mRNA.
Regulation (important) of Positive_regulation (increase) of Fos associated with unmyelinated
11) Confidence 0.06 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1374461 Disease Relevance 0.70 Pain Relevance 1.11

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