INT85252

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Context Info
Confidence 0.01
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Chi3l1, Casp3) mitochondrion (Casp3) endoplasmic reticulum (Chi3l1)
intracellular (Casp3) carbohydrate metabolic process (Chi3l1) cytosol (Casp3)
Chi3l1 (Rattus norvegicus)
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 12 100.00 Very High Very High Very High
Morphine 12 100.00 Very High Very High Very High
antagonist 4 98.56 Very High Very High Very High
nMDA receptor 4 98.12 Very High Very High Very High
Anterior cingulate 4 94.80 High High
Ventral tegmentum 4 73.28 Quite High
Nucleus accumbens 4 72.04 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lesions of the pl mPFC blocked CPP induced by cocaine (15 mg/kg) and CGP37849, and lesions of the cg mPFC only blocked CGP37849-induced CPP.
Negative_regulation (blocked) of CGP37849 Positive_regulation (induced) of CPP associated with cocaine
1) Confidence 0.01 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10583498 Disease Relevance 0 Pain Relevance 0.58
Lesions of the whole mPFC blocked morphine-, cocaine- and CGP37849-induced CPP.
Negative_regulation (blocked) of CGP37849 Positive_regulation (induced) of CPP associated with cocaine and morphine
2) Confidence 0.01 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10583498 Disease Relevance 0 Pain Relevance 0.59
Lesions of the il mPFC blocked CPP induced by morphine (10 mg/kg) and CGP37849 [DL-(E)-2-amino-4-methyl-5-phosphono-3-pentic acid, a competitive N-methyl-D-aspartate receptor antagonist; 10 mg/kg].
Negative_regulation (blocked) of CGP37849 Positive_regulation (induced) of CPP associated with antagonist, nmda receptor and morphine
3) Confidence 0.01 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10583498 Disease Relevance 0 Pain Relevance 0.50
Lesions of the pl mPFC blocked CPP induced by cocaine (15 mg/kg) and CGP37849, and lesions of the cg mPFC only blocked CGP37849-induced CPP.
Negative_regulation (blocked) of CGP37849 Positive_regulation (induced) of CPP associated with cocaine
4) Confidence 0.01 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10583498 Disease Relevance 0 Pain Relevance 0.59

General Comments

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