INT8526

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 5.99
Pain Relevance 17.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
NAcS 4
spinal 2
spinal cord 2
neurons 2
striatum 2
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 96 100.00 Very High Very High Very High
Morphine 55 100.00 Very High Very High Very High
antagonist 35 100.00 Very High Very High Very High
cocaine 25 100.00 Very High Very High Very High
opiate 22 100.00 Very High Very High Very High
qutenza 15 100.00 Very High Very High Very High
Glutamate 12 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
Enkephalin 8 99.98 Very High Very High Very High
c fibre 4 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 161 100.00 Very High Very High Very High
Stress 16 99.68 Very High Very High Very High
Pain 16 99.64 Very High Very High Very High
Targeted Disruption 5 99.36 Very High Very High Very High
Nociception 13 98.88 Very High Very High Very High
INFLAMMATION 107 98.36 Very High Very High Very High
Hyperalgesia 4 96.96 Very High Very High Very High
Disease 6 95.84 Very High Very High Very High
Aids-related Complex 8 91.52 High High
Parkinson's Disease 6 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of c-fos mRNA of CP-treated mice was significantly inhibited by capsaicin pretreatment to deplete C-fibers.
Negative_regulation (inhibited) of Positive_regulation (induction) of c-fos mRNA associated with c fibre and qutenza
1) Confidence 0.59 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18093676 Disease Relevance 0.40 Pain Relevance 0.76
Pretreatment with MK-801 prevented the haloperidol-produced induction of the striatal c-fos mRNA.
Negative_regulation (prevented) of Positive_regulation (induction) of c-fos mRNA
2) Confidence 0.58 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750842 Disease Relevance 0 Pain Relevance 0
Baclofen pretreatment blocked the induction of Fos in opiate conditioned subjects.
Negative_regulation (blocked) of Positive_regulation (induction) of Fos associated with opiate
3) Confidence 0.58 Published 2003 Journal Brain Res. Section Abstract Doc Link 14499954 Disease Relevance 0 Pain Relevance 0.68
Baclofen inhibits opiate-induced conditioned place preference and associated induction of Fos in cortical and limbic regions.
Negative_regulation (inhibits) of Positive_regulation (induction) of Fos associated with opiate
4) Confidence 0.58 Published 2003 Journal Brain Res. Section Title Doc Link 14499954 Disease Relevance 0 Pain Relevance 0.66
It is worth mentioning that the induction of Fos (a member of pattern A) by cocaine is inhibited by ethanol [71-73].
Negative_regulation (inhibited) of Positive_regulation (induction) of Fos associated with cocaine
5) Confidence 0.50 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.17 Pain Relevance 0.17
In the basolateral (BLA) and medial amygdala, restraint stress produced a low level of Fos induction, which was unaffected by cannabinoid treatment.
Negative_regulation (level) of Positive_regulation (induction) of Fos in amygdala associated with stress, cannabinoid and amygdala
6) Confidence 0.43 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15280883 Disease Relevance 0.50 Pain Relevance 0.96
The induction of c-fos mRNA of CP-treated mice was significantly inhibited by capsaicin pretreatment to deplete C-fibers.
Negative_regulation (deplete) of Positive_regulation (induction) of c-fos mRNA associated with c fibre and qutenza
7) Confidence 0.43 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18093676 Disease Relevance 0.40 Pain Relevance 0.77
It is concluded that achievement of adaptive results in the course of learning leads to a suppression of further c-fos induction by motivational excitation.
Negative_regulation (suppression) of Positive_regulation (induction) of c-fos
8) Confidence 0.42 Published 2000 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 10750192 Disease Relevance 0 Pain Relevance 0.12
The functional link between ghrelin and pain was confirmed by inhibition in vitro of the c-fos response to capsaicin activation of nociceptive fibers, after quantification of Fos-immunoreactive nuclei in laminae IV-VI.
Negative_regulation (inhibition) of Positive_regulation (response) of c-fos associated with nociception, pain and qutenza
9) Confidence 0.41 Published 2008 Journal Endocrinology Section Abstract Doc Link 18202139 Disease Relevance 0.25 Pain Relevance 0.70
Treatment with anti-NGF reduced c-Fos and dynorphin up-regulation in the spinal cord at day 2 post-fracture.
Negative_regulation (reduced) of Positive_regulation (up-regulation) of c-Fos in spinal cord associated with dynorphin and spinal cord
10) Confidence 0.41 Published 2007 Journal Pain Section Abstract Doc Link 17693023 Disease Relevance 0.95 Pain Relevance 0.97
In addition, the formalin evoked increase in the number of c-Fos IR neurons is significantly reduced in synapsin II knockout mice.
Negative_regulation (reduced) of Positive_regulation (increase) of c-Fos in neurons associated with targeted disruption
11) Confidence 0.41 Published 2005 Journal Pain Section Abstract Doc Link 15836980 Disease Relevance 0.81 Pain Relevance 0.70
Intra-VTA baclofen administered during morphine pretreatment blocked the acquisition of morphine-induced motor sensitization and Fos activation in the NAcS.
Negative_regulation (blocked) of Positive_regulation (activation) of Fos in NAcS associated with ventral tegmentum and morphine
12) Confidence 0.39 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610238 Disease Relevance 0 Pain Relevance 1.96
Intra-VTA baclofen administered only on day 9 blocked the expression of morphine-induced motor sensitization and Fos activation in the NAcS.
Negative_regulation (blocked) of Positive_regulation (activation) of Fos in NAcS associated with ventral tegmentum and morphine
13) Confidence 0.39 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610238 Disease Relevance 0 Pain Relevance 1.89
A systemic injection of the delta-opioid receptor agonist, [D-Ala2, D-Leu5]enkephalin (DADLE), attenuated the c-fos mRNA increase induced by methamphetamine.
Negative_regulation (attenuated) of Positive_regulation (increase) of c-fos mRNA associated with agonist, enkephalin and opioid receptor
14) Confidence 0.37 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082218 Disease Relevance 0 Pain Relevance 0.37
[D-Ala2, D-Leu5]enkephalin blocks the methamphetamine-induced c-fos mRNA increase in mouse striatum.
Negative_regulation (blocks) of Positive_regulation (increase) of c-fos mRNA in striatum associated with enkephalin
15) Confidence 0.37 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10082218 Disease Relevance 0 Pain Relevance 0.37
The post hoc test showed a significant effect (P < 0.01) of parallel administration of CCK-8 and CART peptide on the Fos activation of cells in NTS in comparison with all other groups of animals (Fig. 3a, d).
Negative_regulation (effect) of Positive_regulation (activation) of Fos associated with medulla and cholecystokinin
16) Confidence 0.30 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.58
The induction of Fos by NaHS but not capsaicin was abolished by mibefradil, a T-type Ca(2+) channel blocker.
Negative_regulation (abolished) of Positive_regulation (induction) of Fos
17) Confidence 0.29 Published 2009 Journal Gut Section Body Doc Link 19201768 Disease Relevance 0.07 Pain Relevance 0
Its close relative c-fos has previously been shown to be upregulated during repair of embryonic skin wounds [11], and in vitro studies show that blocking wound-induced fos induction may hinder cell migration [12].
Negative_regulation (blocking) of Positive_regulation (induction) of fos in skin associated with injury
18) Confidence 0.19 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.72 Pain Relevance 0
Pretreatment with naloxone attenuated the effect of morphine, whereas nor-binaltorphimine, a selective kappa-opioid receptor antagonist, abolished the effect of U-50,488H on Fos induction.
Negative_regulation (abolished) of Positive_regulation (induction) of Fos associated with antagonist, kappa opioid receptor, narcan and morphine
19) Confidence 0.19 Published 2000 Journal Endocrinology Section Abstract Doc Link 10746640 Disease Relevance 0 Pain Relevance 0.90
Intracerebroventricular infusion of the sodium channel blocker, tetrodotoxin, decreased the glutamate-induced increase in phosphorylated cyclic AMP response-element binding protein, phosphorylated Elk-1, and Fos immunoreactivity.
Negative_regulation (decreased) of Positive_regulation (increase) of Fos associated with tetrodotoxin, glutamate, sodium channel and intracerebroventricular
20) Confidence 0.09 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.45

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