INT8527

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 6.87
Pain Relevance 9.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
brain 6
striatum 4
hippocampus 3
nucleus 2
amygdala 2
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 15 100.00 Very High Very High Very High
Glutamate 13 100.00 Very High Very High Very High
Physical dependence 6 99.76 Very High Very High Very High
agonist 26 99.68 Very High Very High Very High
dopamine receptor 5 99.56 Very High Very High Very High
Enkephalin 11 99.50 Very High Very High Very High
Inflammation 90 99.38 Very High Very High Very High
amygdala 32 99.20 Very High Very High Very High
unmyelinated 4 99.20 Very High Very High Very High
withdrawal 28 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Catalepsy 2 100.00 Very High Very High Very High
Injury 163 99.98 Very High Very High Very High
Food Hypersensitivity 5 99.88 Very High Very High Very High
Drug Dependence 6 99.76 Very High Very High Very High
INFLAMMATION 116 99.38 Very High Very High Very High
Stress 111 99.36 Very High Very High Very High
Targeted Disruption 25 99.36 Very High Very High Very High
Hypersensitivity 6 98.56 Very High Very High Very High
Nociception 3 97.88 Very High Very High Very High
Hepatotoxicity 1 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, non-noxious stimulation induced an increase of Fos positive neurons in the spinal cord of animals with tying of sciatic nerve.
Positive_regulation (induced) of Positive_regulation (increase) of Fos in sciatic nerve associated with sciatic nerve and spinal cord
1) Confidence 0.70 Published 2008 Journal Brain Res. Section Abstract Doc Link 18302958 Disease Relevance 0.78 Pain Relevance 0.85
Deletion of the DA D1 receptor increased the responsiveness of enkephalin neurons to haloperidol, in that haloperidol-induced increases in c-Fos and catalepsy were enhanced in D1 receptor knockout mice.
Positive_regulation (enhanced) of Positive_regulation (increases) of c-Fos in neurons associated with targeted disruption, dopamine, catalepsy and enkephalin
2) Confidence 0.67 Published 2002 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12048106 Disease Relevance 0.20 Pain Relevance 0.53
DEM, APAP, and CCl(4) increased c-jun and c-fos mRNA levels, together with an increase in AP-1 binding; BSO failed to induce AP-1 despite an increase in c-fos.
Neg (failed) Positive_regulation (induce) of Neg (failed) Positive_regulation (increase) of c-fos
3) Confidence 0.49 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.29 Pain Relevance 0.08
The c-fos response to D1 receptor activation in adults requires a previous sensitization of dopaminergic receptors by chronic treatment with reserpine or by lesion of the nigro-striatal pathway.
Positive_regulation (requires) of Positive_regulation (response) of c-fos
4) Confidence 0.49 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.25
We found that a single administration of Sub P (0.5 nM) caused an increase of the c-fos mRNA level in the hypothalamic-pituitary-adrenal (HPA) axis, hippocampus, and spinal cord.
Positive_regulation (caused) of Positive_regulation (increase) of c-fos mRNA in hippocampus associated with hippocampus and spinal cord
5) Confidence 0.48 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15460449 Disease Relevance 0 Pain Relevance 0.30
Food allergy also induced enhanced Fos immunoreactivity in the nucleus of tractus solitarii (NTS) of OVA-immunized animals.
Positive_regulation (induced) of Positive_regulation (enhanced) of Fos in nucleus associated with food hypersensitivity
6) Confidence 0.48 Published 2004 Journal Brain Res. Section Abstract Doc Link 15120595 Disease Relevance 0.52 Pain Relevance 0.69
Subjecting rats or mice to acute stressors such as restraint or forced swim results in activation of c-fos gene and/or Fos protein expression in many brain regions) [21-24].
Positive_regulation (results) of Positive_regulation (activation) of c-fos in brain
7) Confidence 0.45 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.66 Pain Relevance 0.23
The administration of methamphetamine caused an increase of c-fos mRNA in the striatum of the mouse.
Positive_regulation (caused) of Positive_regulation (increase) of c-fos mRNA in striatum
8) Confidence 0.40 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082218 Disease Relevance 0 Pain Relevance 0.34
A systemic injection of the delta-opioid receptor agonist, [D-Ala2, D-Leu5]enkephalin (DADLE), attenuated the c-fos mRNA increase induced by methamphetamine.
Positive_regulation (induced) of Positive_regulation (increase) of c-fos mRNA associated with agonist, enkephalin and opioid receptor
9) Confidence 0.40 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10082218 Disease Relevance 0 Pain Relevance 0.37
Infiltration of the inflammatory cells and necrotic areas were increased after increase of c-fos due to stimulation by isoproterenol.
Positive_regulation (increased) of Positive_regulation (increase) of fos associated with inflammation
10) Confidence 0.38 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 1.48 Pain Relevance 0.17
These results demonstrate that clozapine induction of c-fos messenger RNA is not dependent on the D3 dopamine receptor subtype in the striatum or nucleus accumbens.
Neg (not) Positive_regulation (dependent) of Positive_regulation (induction) of c-fos messenger RNA in striatum associated with nucleus accumbens and dopamine receptor
11) Confidence 0.35 Published 1999 Journal Neuroscience Section Abstract Doc Link 10218801 Disease Relevance 0 Pain Relevance 0.56
Its close relative c-fos has previously been shown to be upregulated during repair of embryonic skin wounds [11], and in vitro studies show that blocking wound-induced fos induction may hinder cell migration [12].
Positive_regulation (induced) of Positive_regulation (induction) of fos in skin associated with injury
12) Confidence 0.23 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.71 Pain Relevance 0
We found that a single administration of Sub P (0.5 nM) caused an increase of the c-fos mRNA level in the hypothalamic-pituitary-adrenal (HPA) axis, hippocampus, and spinal cord.
Positive_regulation (caused) of in spinal cord Positive_regulation (increase) of c-fos mRNA in hippocampus associated with hippocampus and spinal cord
13) Confidence 0.16 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15460449 Disease Relevance 0 Pain Relevance 0.30
Simultaneous infusion of glutamate and Sp-8-Br-cAMPS, a cyclic AMP analogue, augmented induction of Fos immunoreactivity but not phosphorylated cyclic AMP response-element binding protein or phosphorylated Elk-1 immunoreactivity.
Neg (not) Positive_regulation (augmented) of Positive_regulation (induction) of Fos associated with glutamate
14) Confidence 0.15 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11208903 Disease Relevance 0 Pain Relevance 0.47
The combination of restraint stress and CB1 agonist administration produced robust Fos induction within the central amygdala, indicating a synergistic interaction between environmental stress and CB1 receptor activation.
Positive_regulation (produced) of Positive_regulation (induction) of Fos in amygdala associated with stress, agonist and amygdala
15) Confidence 0.13 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906867 Disease Relevance 0.71 Pain Relevance 0.57
The data indicate that input from small-diameter unmyelinated primary afferents is important for the stimulus-induced increase in Fos-LI and PPD mRNA.
Positive_regulation (stimulus-induced) of Positive_regulation (increase) of Fos associated with unmyelinated
16) Confidence 0.07 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1374461 Disease Relevance 0.70 Pain Relevance 1.11
The increased levels of extracellular glutamate, NMDA receptor zeta subunit (NR1) mRNA, NMDA receptor epsilon 1 subunit (NR2A) protein, phosphorylated Ca(2+)/calmodulin kinase II (p-CaMKII) protein, c-fos mRNA, c-Fos protein, are observed in the specific brain areas of mice and/or rats showing signs of naloxone-precipitated withdrawal.
Positive_regulation (increased) of Positive_regulation (levels) of c-fos mRNA in brain associated with glutamate, nmda receptor, narcan and withdrawal
17) Confidence 0.06 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464026 Disease Relevance 0.36 Pain Relevance 0.93
The increased levels of extracellular glutamate, NMDA receptor zeta subunit (NR1) mRNA, NMDA receptor epsilon 1 subunit (NR2A) protein, phosphorylated Ca(2+)/calmodulin kinase II (p-CaMKII) protein, c-fos mRNA, c-Fos protein, are observed in the specific brain areas of mice and/or rats showing signs of naloxone-precipitated withdrawal.
Positive_regulation (observed) of Positive_regulation (levels) of c-fos mRNA in brain associated with glutamate, nmda receptor, narcan and withdrawal
18) Confidence 0.06 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464026 Disease Relevance 0.36 Pain Relevance 0.94
The adenylyl cyclase inhibitor 2',5'-dideoxyadenosine, which attenuated the chronic carbachol-induced increase in cAMP concentration, prevented the increased phosphorylation of CREB and the enhanced accumulation of c-fos mRNA during atropine-induced withdrawal.
Positive_regulation (enhanced) of Positive_regulation (accumulation) of c-fos mRNA associated with withdrawal
19) Confidence 0.02 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.43
In cells treated with carbachol for 48 hr, induction of withdrawal with the muscarinic antagonist atropine led to a small increase in intracellular cAMP concentration but an 11.6-fold increase in the phosphorylation of CREB and a 3.4-fold increase in accumulation of c-fos mRNA.
Positive_regulation (increase) of Positive_regulation (accumulation) of c-fos mRNA associated with antagonist and withdrawal
20) Confidence 0.02 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7476883 Disease Relevance 0 Pain Relevance 0.50

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