INT85277

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1999
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 6.03
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (NUDT6) nucleus (NUDT6) cellular_component (NUDT6)
biological_process (NUDT6) cytoplasm (NUDT6)
Anatomy Link Frequency
extracellular matrix 2
NUDT6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 12 98.04 Very High Very High Very High
metalloproteinase 13 93.68 High High
Angina 4 93.56 High High
rheumatoid arthritis 121 90.72 High High
fibrosis 16 90.68 High High
cytokine 37 89.44 High High
Potency 4 84.84 Quite High
Inflammation 50 54.48 Quite High
Arthritis 10 15.92 Low Low
abdominal pain 4 13.64 Low Low
Disease Link Frequency Relevance Heat
Eosinophilic Esophagitis 424 100.00 Very High Very High Very High
Disease 85 97.68 Very High Very High Very High
Fibrosis 24 97.16 Very High Very High Very High
Stroke 4 94.60 High High
Increased Venous Pressure Under Development 9 94.12 High High
Cv General 3 Under Development 4 93.56 High High
Gastroesophageal Reflux Disease 144 92.80 High High
Osteoarthritis 18 91.12 High High
Rheumatoid Arthritis 121 90.72 High High
Injury 8 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We designed a molecule structurally unrelated to all FGFs, which potently mimicked basic FGF activity, by combining domains that (1) bind FGF receptors (2) bind heparin, and (3) mediate dimerization.
FGF Binding (bind) of
1) Confidence 0.38 Published 1999 Journal Nat. Biotechnol. Section Abstract Doc Link 10585718 Disease Relevance 0.28 Pain Relevance 0.17
A 26-residue peptide identified by phage display specifically bound FGF receptor (FGFR) 1c extracellular domain but had no homology with FGFs.
FGF Binding (bound) of
2) Confidence 0.38 Published 1999 Journal Nat. Biotechnol. Section Abstract Doc Link 10585718 Disease Relevance 0.27 Pain Relevance 0.19
We designed a molecule structurally unrelated to all FGFs, which potently mimicked basic FGF activity, by combining domains that (1) bind FGF receptors (2) bind heparin, and (3) mediate dimerization.
FGF Binding (bind) of
3) Confidence 0.29 Published 1999 Journal Nat. Biotechnol. Section Abstract Doc Link 10585718 Disease Relevance 0.28 Pain Relevance 0.17
Our results demonstrate the feasibility of engineering potent artificial agonists for the receptor tyrosine kinases, and have important implications for the design of nonpeptidic ligands for FGF receptors.
FGF Binding (ligands) of associated with agonist
4) Confidence 0.29 Published 1999 Journal Nat. Biotechnol. Section Abstract Doc Link 10585718 Disease Relevance 0.19 Pain Relevance 0.24
Specifically, we focused on examining immune indicators associated with EoE, for example, eotaxin and FGF.
FGF Spec (examining) Binding (associated) of associated with eosinophilic esophagitis
5) Confidence 0.08 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.82 Pain Relevance 0
Additionally, FGF is irreversibly bound to the extracellular matrix after its release, further amplifying its fibrotic capabilities [26].
FGF Binding (bound) of in extracellular matrix associated with fibrosis
6) Confidence 0.08 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.36 Pain Relevance 0.21
Specifically, we focused on examining immune indicators associated with EoE, for example, eotaxin and FGF.
FGF Spec (examining) Binding (associated) of associated with eosinophilic esophagitis
7) Confidence 0.06 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.82 Pain Relevance 0
Since the FGF-9 antibody was made against the entire length of the amino acid, it is likely that homologous isoforms of FGF such as bFGF were also recognized.
FGF Spec (likely) Binding (recognized) of
8) Confidence 0.06 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.15 Pain Relevance 0.11
These enzymes may play a role in angiogenesis by releasing growth factors such as FGF, VEGF and HGF that are bound to heparan sulphate in the extracellular matrix [84,129].
FGF Binding (bound) of in extracellular matrix
9) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.85 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox