INT8528

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 100
Total Number 101
Disease Relevance 41.15
Pain Relevance 55.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
spinal cord 18
spinal 13
dorsal horn 7
lateral 6
brain 6
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 255 100.00 Very High Very High Very High
Morphine 251 100.00 Very High Very High Very High
spinal dorsal horn 131 100.00 Very High Very High Very High
antagonist 97 100.00 Very High Very High Very High
withdrawal 70 100.00 Very High Very High Very High
Kinase C 40 100.00 Very High Very High Very High
imagery 33 100.00 Very High Very High Very High
addiction 30 100.00 Very High Very High Very High
qutenza 29 100.00 Very High Very High Very High
tolerance 26 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 393 100.00 Very High Very High Very High
Injury 165 100.00 Very High Very High Very High
Nociception 113 100.00 Very High Very High Very High
Anxiety Disorder 78 100.00 Very High Very High Very High
Aids-related Complex 63 100.00 Very High Very High Very High
Sleep Disorders 45 100.00 Very High Very High Very High
Shock 19 100.00 Very High Very High Very High
Morphine Dependence 10 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

8 100.00 Very High Very High Very High
Neuropathic Pain 135 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All three antagonists consistently blocked Fos expression in the prefrontal cortex, but not in the VTA and striatum.
Negative_regulation (blocked) of Gene_expression (expression) of Fos in striatum associated with ventral tegmentum and antagonist
1) Confidence 0.59 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17467070 Disease Relevance 0 Pain Relevance 1.13
BV injection into the acupoint produced a dose dependent suppression of acetic acid-induced abdominal stretches and of acetic acid-induced Fos expression in the spinal cord and the nucleus tractus solitarii.
Negative_regulation (suppression) of Gene_expression (expression) of Fos in nucleus associated with spinal cord
2) Confidence 0.59 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11457577 Disease Relevance 0 Pain Relevance 0.70
The destruction of capsaicin-sensitive primary afferents by resiniferatoxin (RTX) pretreatment selectively decreased BV-induced spinal Fos expression but did not affect BV-induced antinociception.
Negative_regulation (decreased) of Gene_expression (expression) of Fos in spinal associated with antinociception and qutenza
3) Confidence 0.59 Published 2006 Journal J Pain Section Abstract Doc Link 16814689 Disease Relevance 0.46 Pain Relevance 0.69
Tetrandrine could inhibit the c-fos gene expression in nucleus accumbens, ventral tegmental and prefrontal cortex in place-preference model formed by morphine.
Negative_regulation (inhibit) of Gene_expression (expression) of c-fos gene in prefrontal
4) Confidence 0.59 Published 2001 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 12577398 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Tetrandrine could inhibit the hyperactivity and conditioned place preference response induced by morphine, it might relate to reducing the c-fos gene expression in special area of brain in mice.


Negative_regulation (reducing) of Gene_expression (expression) of c-fos gene in brain
5) Confidence 0.59 Published 2001 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 12577398 Disease Relevance 0 Pain Relevance 0
The antiFos oligonucleotide injections reduced Fos expression at the injection site in neurons which normally express Fos after the lesion, and also affected circling behavior induced by hemilabyrinthectomy.
Negative_regulation (reduced) of Gene_expression (expression) of Fos in neurons
6) Confidence 0.58 Published 1999 Journal Brain Res. Section Abstract Doc Link 9889379 Disease Relevance 0 Pain Relevance 0.21
Unilateral intra-LS morphine (100 or 500 ng/100 nl) decreased open-arm exploration in the plus-maze and reduced head-dipping frequency in the hole-board, an anxiogenic-like effect associated with decreased Fos expression in the ventral LS, the dorsal hippocampus and the anterior hypothalamus.
Negative_regulation (decreased) of Gene_expression (expression) of Fos in anterior associated with hippocampus and morphine
7) Confidence 0.57 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16626794 Disease Relevance 0.41 Pain Relevance 1.17
cFos mRNA expression was also found to be decreased by the treatment in comparison to the control group.
Negative_regulation (decreased) of Gene_expression (expression) of cFos mRNA
8) Confidence 0.57 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
The decreased expression of cFos mRNA as a result of reduced image quality was determined by microarray analysis after 4 h of treatment.
Negative_regulation (decreased) of Spec (determined) Gene_expression (expression) of cFos mRNA
9) Confidence 0.57 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.16 Pain Relevance 0.05
Consistently, honokiol and magnolol significantly decreased formalin-induced c-Fos protein expression in superficial (I-II) laminae of the L4-L5 lumbar dorsal horn.
Negative_regulation (decreased) of Gene_expression (expression) of c-Fos in dorsal horn associated with dorsal horn
10) Confidence 0.57 Published 2007 Journal Life Sci. Section Abstract Doc Link 17826802 Disease Relevance 0.59 Pain Relevance 0.69
In addition, c-Fos expression in the crescent part of the lateral parabrachial nucleus was decreased in PBG-injected mice whereas no significant differences were detected between PBG-injected and control mice in the number of c-Fos-positive nuclei in the dorsal part of the lateral parabrachial nucleus.
Negative_regulation (decreased) of Gene_expression (expression) of c-Fos in lateral associated with porphyria and parabrachial
11) Confidence 0.57 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 16298172 Disease Relevance 0.79 Pain Relevance 0.45
CONCLUSION: The ribozyme specially cleaving per1 mRNA has potential function in inhibiting the transcription and expression of c-fos and blocking the morphine addiction.


Negative_regulation (inhibiting) of Gene_expression (expression) of c-fos
12) Confidence 0.57 Published 2005 Journal Space Med Med Eng (Beijing) Section Body Doc Link 15977398 Disease Relevance 0 Pain Relevance 0
Deletion of trpv4 or trpa1 suppressed c-Fos expression and pain behavior, and deletion of trpa1 attenuated pancreatitis.
Negative_regulation (suppressed) of Gene_expression (expression) of c-Fos associated with pain and pancreatitis
13) Confidence 0.57 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539005 Disease Relevance 1.53 Pain Relevance 1.33
The ASIC blocker amiloride inhibited acid-induced c-Fos expression in F-11 cells.
Negative_regulation (inhibited) of Gene_expression (expression) of c-Fos associated with asic
14) Confidence 0.57 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.30 Pain Relevance 0.91
Intracerebro-ventricular injection of 1 nmol dNPA alone produced an overall inhibition of basal c-Fos expression in the brain with a statistically significant decrease in the lateral ventral part of the bed nucleus of the stria terminalis, the medial preoptic area, and the medial parvicellular part of the paraventricular nucleus of the hypothalamus.
Negative_regulation (inhibition) of Gene_expression (expression) of c-Fos in medial associated with urological neuroanatomy
15) Confidence 0.57 Published 2010 Journal Synapse Section Abstract Doc Link 20336629 Disease Relevance 0.09 Pain Relevance 0.69
However, anti-NGF treatment did not reduce p-ERK and c-Fos expression at 20 and 90 min, respectively, following fracture.
Neg (not) Negative_regulation (reduce) of Gene_expression (expression) of c-Fos
16) Confidence 0.57 Published 2007 Journal Pain Section Abstract Doc Link 17693023 Disease Relevance 0.93 Pain Relevance 0.94
[Effect of connexin 43 knockout on acupuncture-induced down-regulation of c-fos expression in spinal dorsal horn in visceral pain mice].
Negative_regulation (regulation) of Gene_expression (expression) of c-fos in spinal associated with targeted disruption, pain, visceral pain, spinal dorsal horn and acupuncture
17) Confidence 0.57 Published 2008 Journal Zhen Ci Yan Jiu Section Title Doc Link 18807720 Disease Relevance 0.10 Pain Relevance 0.54
Our correlative studies have shown that isoflurane can decrease the paw licking times and simultaneously suppress c-fos expression after injection of formalin in the mice.
Negative_regulation (suppress) of Gene_expression (expression) of c-fos in paw associated with isoflurane
18) Confidence 0.57 Published 2009 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 19389046 Disease Relevance 0.07 Pain Relevance 1.13
Propofol acts at the sigma-1 receptor and inhibits pentazocine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices.
Negative_regulation (inhibits) of Gene_expression (expression) of Fos in posterior associated with fortral
19) Confidence 0.57 Published 2006 Journal Acta Anaesthesiol Scand Section Title Doc Link 16879472 Disease Relevance 0 Pain Relevance 0.29
Intrathecal landiolol inhibits nociception and spinal c-Fos expression in the mouse formalin test.
Negative_regulation (inhibits) of Gene_expression (expression) of c-Fos in spinal associated with nociception and intrathecal
20) Confidence 0.57 Published 2007 Journal Can J Anaesth Section Title Doc Link 17331932 Disease Relevance 0.10 Pain Relevance 0.49

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