INT8529

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Context Info
Confidence 0.39
First Reported 1990
Last Reported 2003
Negated 2
Speculated 2
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 1.26
Pain Relevance 5.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
striatum 7
hypothalamus 2
spinal 2
neurons 2
spinal cord 2
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 25 100.00 Very High Very High Very High
Enkephalin 23 100.00 Very High Very High Very High
Morphine 21 100.00 Very High Very High Very High
Dopamine 12 100.00 Very High Very High Very High
Inflammation 11 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
qutenza 6 99.74 Very High Very High Very High
Spinal cord 5 99.68 Very High Very High Very High
GABA receptor 1 99.54 Very High Very High Very High
Neuropeptide 10 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
Pressure And Volume Under Development 1 100.00 Very High Very High Very High
Stress 4 99.60 Very High Very High Very High
Pain 1 91.40 High High
Nociception 1 84.16 Quite High
Aids-related Complex 3 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied the effects of 10 micrograms of 17-beta-estradiol-3-benzoate treatment on preproenkephalin (PPE) mRNA expression in female ovariectomized (OVX) Swiss Webster mice after 0, 1, 6, 12, 24, or 48 h, using the in situ hybridization technique.
Regulation (effects) of Transcription (expression) of preproenkephalin
1) Confidence 0.39 Published 1996 Journal J. Chem. Neuroanat. Section Abstract Doc Link 9001946 Disease Relevance 0.05 Pain Relevance 0.03
In contrast to PDYN, the PENK mRNA level was reduced in the nucleus accumbens and remained unchanged in the striatum following repeated morphine administration.
Neg (unchanged) Regulation (unchanged) of Transcription (level) of PENK in striatum associated with nucleus accumbens and morphine
2) Confidence 0.39 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.98
Effects of single (20 mg/kg i.p.) and repeated morphine administration (increasing doses: from 10 to 50 mg/kg i.p. twice daily for 7 days) on the proenkephalin (PENK), prodynorphin (PDYN) and dopamine D2 receptor (D2) mRNA levels in the nucleus accumbens and striatum of the mouse were investigated.
Spec (investigated) Regulation (Effects) of in nucleus accumbens Transcription (levels) of PENK in striatum associated with nucleus accumbens, dopamine and morphine
3) Confidence 0.39 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.71
These data are consistent with evidence supporting the role of Fos and Fos-related proteins in the regulation of transcription of the preproenkephalin gene in spinal neurons.
Regulation (regulation) of Transcription (transcription) of preproenkephalin in spinal
4) Confidence 0.21 Published 1992 Journal Neuroscience Section Abstract Doc Link 1545910 Disease Relevance 0.22 Pain Relevance 0.25
Enkephalin biosynthesis and release in mouse striatum are inhibited by GABA receptor stimulation: compared changes in preproenkephalin mRNA and Tyr-Gly-Gly levels.
Regulation (changes) of Transcription (levels) of preproenkephalin in striatum associated with gaba receptor and enkephalin
5) Confidence 0.21 Published 1990 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 2170800 Disease Relevance 0 Pain Relevance 0.89
Effects of single (20 mg/kg i.p.) and repeated morphine administration (increasing doses: from 10 to 50 mg/kg i.p. twice daily for 7 days) on the proenkephalin (PENK), prodynorphin (PDYN) and dopamine D2 receptor (D2) mRNA levels in the nucleus accumbens and striatum of the mouse were investigated.
Spec (investigated) Regulation (Effects) of Transcription (levels) of PENK in striatum associated with nucleus accumbens, dopamine and morphine
6) Confidence 0.13 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.71
Preproenkephalin mRNA expression by striatopallidal neurons was unchanged at 48 h, but increased by 44% at 120 h.
Neg (unchanged) Regulation (unchanged) of Transcription (expression) of Preproenkephalin in neurons
7) Confidence 0.11 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11161620 Disease Relevance 0 Pain Relevance 0.53
This study tested the hypothesis that testosterone and/or season modulate preproenkephalin mRNA expression in specific areas of the hypothalamus.
Regulation (modulate) of Transcription (expression) of preproenkephalin in hypothalamus
8) Confidence 0.08 Published 2003 Journal Biol. Reprod. Section Abstract Doc Link 12930728 Disease Relevance 0 Pain Relevance 0.19
Preproenkephalin mRNA levels are regulated by acute stress and estrogen stimulation.
Regulation (regulated) of Transcription (levels) of Preproenkephalin associated with stress and enkephalin
9) Confidence 0.04 Published 2000 Journal Physiol. Behav. Section Title Doc Link 10913780 Disease Relevance 0.18 Pain Relevance 0.45
Capsaicin had minimal effects on the behavioral hyperalgesia and edema associated with the hindpaw inflammation and on the constitutive expression of preprodynorphin (PPD) mRNA and preproenkephalin mRNA in the spinal cord.
Regulation (effects) of Transcription (expression) of preproenkephalin mRNA in spinal cord associated with pressure and volume under development, hyperalgesia, inflammation, qutenza and spinal cord
10) Confidence 0.01 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1374461 Disease Relevance 0.81 Pain Relevance 1.15

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