INT85297

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 29.77
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
Anatomy Link Frequency
chest 6
plasma 4
myocyte 2
filament 2
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 89 100.00 Very High Very High Very High
Inflammation 142 99.84 Very High Very High Very High
imagery 48 97.86 Very High Very High Very High
Migraine 1 96.76 Very High Very High Very High
Inflammatory marker 19 94.20 High High
cva 26 84.20 Quite High
aspirin 1 84.12 Quite High
depression 21 83.72 Quite High
Inflammatory response 72 80.36 Quite High
ischemia 76 71.04 Quite High
Disease Link Frequency Relevance Heat
Pyometra 1020 100.00 Very High Very High Very High
Acute Coronary Syndrome 173 100.00 Very High Very High Very High
Necrosis 91 100.00 Very High Very High Very High
Angina 80 100.00 Very High Very High Very High
Thrombosis 11 100.00 Very High Very High Very High
Myocardial Infarction 111 99.92 Very High Very High Very High
Bacterial Infection 102 99.88 Very High Very High Very High
INFLAMMATION 197 99.84 Very High Very High Very High
Cv General 2 Under Development 41 99.70 Very High Very High Very High
Coronary Artery Disease 77 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated cTnI levels were not found to be an independent predictor of mortality regardless of APACHE II score (OR 2.8, 95% CI 0.87–9.2, p = 0.085).
Positive_regulation (Elevated) of Gene_expression (levels) of cTnI
1) Confidence 0.50 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.15 Pain Relevance 0
Among elderly (older than 65 years) patients (n = 49) with elevated cTnI levels, the 28-day mortality rate was 10/15 patients (66.7%), while the mortality rate among elderly patients with normal cTnI levels was only 4/34 patients (11.8%).
Positive_regulation (elevated) of Gene_expression (levels) of cTnI
2) Confidence 0.50 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.05 Pain Relevance 0
Furthermore we ruled out relevant CAD as an alternative cause for cTnI elevation in the majority of the cTnI-positive patients.
Positive_regulation (cause) of Gene_expression (elevation) of cTnI associated with coronary artery disease
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815772 Disease Relevance 1.13 Pain Relevance 0
Measurements of cardiac troponin I concentration
Positive_regulation (Measurements) of Gene_expression (concentration) of cardiac troponin I
4) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.27 Pain Relevance 0.08
Elevated serum levels of cardiac troponin I (cTnI), a myocardial regulatory protein of the thin actin filament, are considered highly sensitive and specific indicators of myocardial injury [10].
Positive_regulation (Elevated) of Gene_expression (levels) of cTnI in filament associated with injury
5) Confidence 0.47 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 1.14 Pain Relevance 0
Increased cTnI levels have also been demonstrated in azotaemic cats and dogs [37].
Positive_regulation (Increased) of Gene_expression (levels) of cTnI
6) Confidence 0.46 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 0.88 Pain Relevance 0
There was a trend for increased mortality in the pyometra patients with detectable cTnI levels (Fisher's exact test, P = 0.067).


Positive_regulation (increased) of Gene_expression (levels) of cTnI associated with pyometra
7) Confidence 0.46 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.03 Pain Relevance 0
However, cTnI levels may increase minimally in healthy animals due to strenuous exercise or noncardiac disease in some cases [5].
Spec (may) Positive_regulation (increase) of Gene_expression (levels) of cTnI associated with disease
8) Confidence 0.46 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 0.81 Pain Relevance 0
In one of the two female dogs (no.1) with the highest preoperative cTnI levels (0.9 ?
Positive_regulation (preoperative) of Gene_expression (levels) of cTnI
9) Confidence 0.46 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.00 Pain Relevance 0
Measurement of these parameters was thus not useful to predict or identify dogs with increased cTnI levels despite previous reports of an association of TNF-?
Positive_regulation (increased) of Gene_expression (levels) of cTnI
10) Confidence 0.46 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.68 Pain Relevance 0.05
The remaining control dog (11%) had cTnI levels of 0.3 ?
Positive_regulation (had) of Gene_expression (levels) of cTnI
11) Confidence 0.46 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.04 Pain Relevance 0
In one of these cases (later diagnosed with myocarditis and disseminated bacterial infection) the cTnI levels increased from 0.9 ?
Positive_regulation (increased) of Gene_expression (levels) of cTnI associated with bacterial infection and coronary heart disease
12) Confidence 0.46 Published 2007 Journal Acta Vet Scand Section Abstract Doc Link PMC1839102 Disease Relevance 1.15 Pain Relevance 0.07
The preoperative cTnI levels of 0.9 ?
Positive_regulation (preoperative) of Gene_expression (levels) of cTnI
13) Confidence 0.46 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.30 Pain Relevance 0.03
The aim of this study was to determine the prevalence and clinical significance of an elevated cardiac troponin I (cTnI) in patients presenting to the Emergency Department without chest pain.
Spec (determine) Positive_regulation (elevated) of Spec (determine) Gene_expression (prevalence) of cTnI in chest associated with angina and emergencies
14) Confidence 0.45 Published 2006 Journal Eur. J. Intern. Med. Section Abstract Doc Link 16490684 Disease Relevance 0.54 Pain Relevance 0.36
Seven dogs with pyometra (12%) and one control dog (11%) had increased levels of cTnI.
Positive_regulation (increased) of Gene_expression (levels) of cTnI associated with pyometra
15) Confidence 0.43 Published 2007 Journal Acta Vet Scand Section Abstract Doc Link PMC1839102 Disease Relevance 1.24 Pain Relevance 0.09
In the present study, 7 of the 58 dogs with pyometra had increased plasma levels of cTnI.
Positive_regulation (increased) of Gene_expression (levels) of cTnI in plasma associated with pyometra
16) Confidence 0.43 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 0.46 Pain Relevance 0
Since even slightly increased levels of cTnI indicate myocyte injury, the analysis adds diagnostic and prognostic value to other clinical examinations in identifying patients at risk of cardiac events.
Positive_regulation (increased) of Gene_expression (levels) of cTnI in myocyte associated with injury
17) Confidence 0.43 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.25 Pain Relevance 0.13
Increased cTnI levels were observed in 12% of the dogs with pyometra.
Positive_regulation (Increased) of Gene_expression (levels) of cTnI associated with pyometra
18) Confidence 0.43 Published 2007 Journal Acta Vet Scand Section Abstract Doc Link PMC1839102 Disease Relevance 0.92 Pain Relevance 0.03
Levels of cTnI are, on average, detectable four to six hours from the onset of chest pain, peaking in twelve hours and remaining elevated for three to ten days, making it an ideal marker for the detection of both acute as well as delayed AICS presentations [26].
Positive_regulation (elevated) of Gene_expression (Levels) of cTnI in chest associated with angina and syndrome
19) Confidence 0.41 Published 2004 Journal BMC Emerg Med Section Body Doc Link PMC487900 Disease Relevance 0.67 Pain Relevance 0.18
The other pyometra case that was examined post mortem had preoperative cTnI values of 0.7 ?
Positive_regulation (preoperative) of Gene_expression (values) of cTnI associated with pyometra
20) Confidence 0.40 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.06 Pain Relevance 0

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