INT85301

Context Info Confidence 0.52 First Reported 1999 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 4.19 Pain Relevance 4.50

extracellular space (Ndp) extracellular region (Ndp) cellular_component (Ndp) biological_process (Ndp)

Anatomy Link Frequency nerve 1 cortex 1 Ndp (Rattus norvegicus)

Pain Link Frequency Relevance Heat headache 199 100.00 Pain 46 100.00 Anterior cingulate cortex 3 99.36 central pain 2 99.20 Migraine 79 98.96 Pain threshold 8 95.76 neuralgia 1 83.68 Anterior cingulate 3 75.00 Cluster headache 8 5.00 cva 3 5.00

Disease Link Frequency Relevance Heat Headache 190 100.00 Pain 45 100.00 Headache Disorders 69 98.04 Neuralgia 1 83.68 Hyperacusis 2 59.76 Photophobia 2 59.16 Vomiting 2 57.80 Disorders Of The Lacrimal System 2 44.16 Ocular Toxicity (including Many Sub-types) 1 42.88 Primary Headache Disorders 7 36.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Rather, our evidence to date suggests that the NDP is generated by activity in the central pain pathways.

Gene_expression (generated) of NDP associated with pain and central pain

1) Confidence 0.52 Published 1999 Journal Neurophysiol Clin Section Abstract Doc Link 10587952 Disease Relevance 0.50 Pain Relevance 0.76

Hence, although the results of this experiment did not confirm our hypothesis that the NDP is generated in SI, they are consistent with the hypothesis that the NDP is generated in the supraspinal pain pathways.

Gene_expression (generated) of NDP

2) Confidence 0.48 Published 1999 Journal Clin Neurophysiol Section Body Doc Link 10616116 Disease Relevance 0.07 Pain Relevance 0

This experiment evaluated a hypothesis derived from our earlier work, namely that the NDP is generated by pain-related activity in the primary somatosensory (SI) cortex.

Gene_expression (generated) of NDP in cortex associated with pain

3) Confidence 0.48 Published 1999 Journal Clin Neurophysiol Section Abstract Doc Link 10616116 Disease Relevance 0.45 Pain Relevance 0.49

Hence, although the results of this experiment did not confirm our hypothesis that the NDP is generated in SI, they are consistent with the hypothesis that the NDP is generated in the supraspinal pain pathways.

Gene_expression (generated) of NDP

4) Confidence 0.48 Published 1999 Journal Clin Neurophysiol Section Body Doc Link 10616116 Disease Relevance 0.06 Pain Relevance 0

This study examined the effects of orienting on two pain-related components of the sural nerve-evoked somatosensory evoked potential: the NDP (80-230 ms), which is generated in part by the anterior cingulate cortex (ACCc), and SP6 (280-340 ms).

Gene_expression (generated) of NDP in nerve associated with pain and anterior cingulate cortex

5) Confidence 0.28 Published 2004 Journal Psychophysiology Section Abstract Doc Link 15318881 Disease Relevance 0.45 Pain Relevance 0.66

The ICHD-II addresses NDPH as a single diagnosis in those with a new-onset CDH that resembles CTTH.

Gene_expression (addresses) of NDPH associated with headache

6) Confidence 0.09 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2793374 Disease Relevance 2.66 Pain Relevance 2.60

General Comments

This test has worked.