INT8532

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Context Info
Confidence 0.44
First Reported 1992
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 4.97
Pain Relevance 6.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
brain 6
spinal cord 4
SH-SY5Y 2
putamen 2
internal 2
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 37 100.00 Very High Very High Very High
Enkephalin 22 100.00 Very High Very High Very High
Opioid 14 100.00 Very High Very High Very High
Inflammation 12 100.00 Very High Very High Very High
antagonist 7 100.00 Very High Very High Very High
Hyperalgesia 6 100.00 Very High Very High Very High
qutenza 12 99.74 Very High Very High Very High
Pain 53 98.92 Very High Very High Very High
Neuropeptide 11 98.48 Very High Very High Very High
Spinal cord 14 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 100.00 Very High Very High Very High
Hyperalgesia 6 100.00 Very High Very High Very High
Pressure And Volume Under Development 2 100.00 Very High Very High Very High
Repression 10 99.98 Very High Very High Very High
Epilepsy 4 99.84 Very High Very High Very High
Dyskinesias 2 99.32 Very High Very High Very High
Pain 83 98.92 Very High Very High Very High
Disease 9 97.72 Very High Very High Very High
Malaria 1 96.08 Very High Very High Very High
Nociception 9 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin had minimal effects on the behavioral hyperalgesia and edema associated with the hindpaw inflammation and on the constitutive expression of preprodynorphin (PPD) mRNA and preproenkephalin mRNA in the spinal cord.
Regulation (effects) of Transcription (expression) of PPD in spinal cord associated with pressure and volume under development, hyperalgesia, inflammation, qutenza and spinal cord
1) Confidence 0.44 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1374461 Disease Relevance 0.81 Pain Relevance 1.14
Capsaicin had minimal effects on the behavioral hyperalgesia and edema associated with the hindpaw inflammation and on the constitutive expression of preprodynorphin (PPD) mRNA and preproenkephalin mRNA in the spinal cord.
Regulation (effects) of Transcription (expression) of dynorphin in spinal cord associated with pressure and volume under development, hyperalgesia, inflammation, qutenza and spinal cord
2) Confidence 0.44 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1374461 Disease Relevance 0.81 Pain Relevance 1.14
Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.
Regulation (regulation) of Transcription (transcription) of prodynorphin in temporal lobe associated with epilepsy and enkephalin
3) Confidence 0.44 Published 2009 Journal Hippocampus Section Title Doc Link 19437412 Disease Relevance 0.27 Pain Relevance 0.38
To determine the effect of the selected nucleotide substitutions on PDYN transcription, we transiently transfected the human neural cell line SH-SY5Y with constructs bearing 3 kb of human or chimpanzee PDYN cis-regulatory DNA linked to a luciferase reporter.
Spec (determine) Regulation (effect) of Transcription (transcription) of PDYN in SH-SY5Y
4) Confidence 0.39 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1283535 Disease Relevance 0.10 Pain Relevance 0.04
In vitro and in vivo experiments show a reduction of DREAM mRNA; in both cases, no changes in levels of pdyn mRNA were detected.
Neg (no) Regulation (changes) of Transcription (levels) of pdyn
5) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.77 Pain Relevance 0.94
Surprisingly, Ca(2+)-dependent prodynorphin gene transcription was insensitive to the broad-spectrum kinase inhibitors and sensitive to agents that alter internal Ca(2+) accumulation.
Regulation (sensitive) of Transcription (transcription) of prodynorphin in internal
6) Confidence 0.26 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12676525 Disease Relevance 0.15 Pain Relevance 0
The elevation of substance P mRNA in intrinsic spinal cord neurons may be secondary to changes in immediate early genes c-fos and jun-B, whereas the expression of dynorphin and enkephalin mRNA is differently regulated.
Regulation (regulated) of Transcription (expression) of dynorphin in spinal cord neurons associated with dynorphin, enkephalin, spinal cord and substance p
7) Confidence 0.26 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9429659 Disease Relevance 0.30 Pain Relevance 1.54
Prodynorphin transcripts and proteins differentially expressed and regulated in the adult human brain.
Regulation (regulated) of Transcription (transcripts) of Prodynorphin in brain associated with enkephalin
8) Confidence 0.26 Published 2005 Journal FASEB J. Section Title Doc Link 16014400 Disease Relevance 0 Pain Relevance 0.40
Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pdyn) gene might enhance pain relief in the periphery.


Spec (might) Regulation (effect) of Transcription (transcription) of dynorphin-encoding prodynorphin associated with pain, dynorphin, antagonist, repression and opioid
9) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483451 Disease Relevance 1.00 Pain Relevance 0.88
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
Regulation (Alterations) of Transcription (levels) of prodynorphin in putamen associated with enkephalin and disease
10) Confidence 0.22 Published 2007 Journal J. Neurosci. Res. Section Title Doc Link 17203488 Disease Relevance 0.56 Pain Relevance 0.39
We studied the effects of coadministration of (-)-OSU6162 with l-DOPA on the regulation of striatal preproenkephalin (PPE) and prodynorphin (PDyn) mRNA expression in the primate brain by in situ hybridization histochemistry.
Regulation (effects) of Transcription (expression) of prodynorphin in brain
11) Confidence 0.17 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11312565 Disease Relevance 0.10 Pain Relevance 0.05
We studied the effects of coadministration of (-)-OSU6162 with l-DOPA on the regulation of striatal preproenkephalin (PPE) and prodynorphin (PDyn) mRNA expression in the primate brain by in situ hybridization histochemistry.
Regulation (regulation) of Transcription (expression) of prodynorphin in brain
12) Confidence 0.07 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11312565 Disease Relevance 0.10 Pain Relevance 0.05

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