INT85326

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Context Info
Confidence 0.65
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.90
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
neuronal 1
neurons 1
spinal cord 1
nephron 1
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 9 99.84 Very High Very High Very High
Spinal cord 64 98.64 Very High Very High Very High
aspirin 15 98.00 Very High Very High Very High
qutenza 18 97.76 Very High Very High Very High
Neuropathic pain 25 96.40 Very High Very High Very High
Pain 77 95.76 Very High Very High Very High
Peripheral nervous system 18 93.96 High High
Central nervous system 22 93.48 High High
Eae 30 91.28 High High
c fibre 18 89.20 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 18 99.90 Very High Very High Very High
Nociception 41 99.84 Very High Very High Very High
Ganglion Cysts 14 99.84 Very High Very High Very High
Disease 38 99.36 Very High Very High Very High
Targeted Disruption 30 99.12 Very High Very High Very High
Injury 65 99.08 Very High Very High Very High
Spinal Cord Injury 3 98.64 Very High Very High Very High
Toxicity 1 97.64 Very High Very High Very High
Contusions 3 97.28 Very High Very High Very High
Sprains And Strains 2 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They proposed possible novel roles for AQP1 in the injured spinal cords in neuronal and astrocytic swelling, as AQP1 was increased in all surviving neurons and reactive astrocytes after SCI and in the development of the neuropathic pain after SCI.
Positive_regulation (increased) of AQP1 in neuronal associated with pressure and volume under development, injury and neuropathic pain
1) Confidence 0.65 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.26 Pain Relevance 0.76
These results suggested a functional role for AQP1 in nociceptive neurons [35].
Positive_regulation (role) of AQP1 in neurons associated with nociception
2) Confidence 0.47 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.66 Pain Relevance 0.68
These data support the idea that AQP-1 upregulation in TG might be disease specific.
Positive_regulation (upregulation) of AQP-1 associated with trigeminal ganglion and disease
3) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.20 Pain Relevance 0.87
Rat contusion spinal cord injury (SCI) induced persistent and significant four- to eightfold increases in AQP1 levels at the site of injury (T10) persisting up to 11 months post-contusion.
Positive_regulation (increases) of AQP1 in spinal cord associated with spinal cord injury, injury, contusions and spinal cord
4) Confidence 0.43 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.09 Pain Relevance 0.84
Water and solute transport is represented by the up-regulation of AQP1 and SLC14A1.
Positive_regulation (up) of AQP1
5) Confidence 0.36 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.91 Pain Relevance 0.06
Using free-flow micropuncture techniques, the proximal-distal single-nephron GFR difference was found to be augmented in aquaporin-1 and Na/H exchanger-3 knockout mice, suggesting TGF activation in these strains of mice.
Positive_regulation (augmented) of aquaporin-1 in nephron associated with targeted disruption and sprains and strains
6) Confidence 0.25 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 10589702 Disease Relevance 0.78 Pain Relevance 0.19
Results showed that aspirin treatment significantly decreases AQP6 mRNA expression (about 70%, Figure 3), while no significant changes were observed for AQP1, 2, 4 and 7 transcripts under this condition.
Neg (no) Positive_regulation (changes) of AQP1 associated with aspirin
7) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2810475 Disease Relevance 0 Pain Relevance 0.31

General Comments

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