INT85328

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Context Info
Confidence 0.54
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.02
Pain Relevance 4.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
neurons 1
dorsal horns 1
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 27 99.52 Very High Very High Very High
bradykinin 3 99.24 Very High Very High Very High
nav1.8 12 99.12 Very High Very High Very High
Neuropathic pain 19 98.32 Very High Very High Very High
qutenza 19 97.88 Very High Very High Very High
Pain 68 97.28 Very High Very High Very High
trigeminal ganglion 27 96.56 Very High Very High Very High
allodynia 6 93.64 High High
dorsal root ganglion 6 89.80 High High
Dorsal horn neuron 3 87.84 High High
Disease Link Frequency Relevance Heat
Nociception 46 99.64 Very High Very High Very High
Inflammatory Pain 8 99.52 Very High Very High Very High
Polyuria 1 99.28 Very High Very High Very High
Injury 45 99.12 Very High Very High Very High
Neuropathic Pain 34 98.32 Very High Very High Very High
Volume Depletion And Dehydration 1 98.20 Very High Very High Very High
Pain 74 97.28 Very High Very High Very High
Disease 17 97.24 Very High Very High Very High
Ganglion Cysts 33 96.56 Very High Very High Very High
Congenital Anomalies 1 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, they have shown that decreased AQP1 in melatonin-treated SCI rats correlated with decreased AQP1 immunolabeling in the dorsal horns sensory afferents and with significantly decreased mechanical allodynia, suggesting a possible link between AQP1 and chronic neuropathic pain after SCI [31].
Negative_regulation (decreased) of AQP1 in dorsal horns associated with allodynia, injury and neuropathic pain
1) Confidence 0.54 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 1.28 Pain Relevance 0.70
Humans lacking AQP1 or AQP2 manifest polyuria with defective urinary concentrating ability and humans with mutations in MIP (AQP0) develop cataracts.
Negative_regulation (lacking) of AQP1 associated with polyuria and cataract
2) Confidence 0.49 Published 2002 Journal Ann. Med. Section Abstract Doc Link 12173689 Disease Relevance 0.94 Pain Relevance 0.07
To further determine the role of AQP-1, we found that the deficiency of AQP-1 (mice kindly provided by Dr.
Negative_regulation (deficiency) of AQP-1
3) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.29 Pain Relevance 0.92
Furthermore, recent studies showed that thermal inflammatory pain perception was greatly reduced in AQP1-/- mice evoked by bradykinin, prostaglandin E2, and capsaicin as well as reduced cold pain perception [53].
Negative_regulation (reduced) of AQP1 associated with pain, qutenza, eae and bradykinin
4) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.74 Pain Relevance 1.29
Nav1.8 currents and expression were significantly reduced in AQP1-/- mice DRG neurons.
Negative_regulation (reduced) of AQP1 in neurons associated with nav1.8
5) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.70 Pain Relevance 1.31
In a communication of Oshio and co-workers [34] and after in a ‘commentary work’ of Verkmann [45], the information that mice lacking AQP1 reduced nociception in response to thermal stimuli and capsaisin was reported.
Negative_regulation (lacking) of AQP1 associated with nociception
6) Confidence 0.40 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.39 Pain Relevance 0.50
Aquaporin-1 and Na/H exchanger-3 deficiency enhances TGF suppression of TGF probably by volume depletion-mediated TGF sensitization.
Negative_regulation (deficiency) of Aquaporin-1 associated with volume depletion and dehydration
7) Confidence 0.22 Published 1999 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 10589702 Disease Relevance 0.67 Pain Relevance 0.15

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