INT8533

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 1986
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.01
Pain Relevance 11.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sorbs1) transport (Sorbs1) plasma membrane (Sorbs1)
cytoskeleton (Sorbs1) nucleus (Sorbs1) cytoplasm (Sorbs1)
Anatomy Link Frequency
neurons 3
Sorbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 480 100.00 Very High Very High Very High
qutenza 304 100.00 Very High Very High Very High
Neuropeptide 55 100.00 Very High Very High Very High
Action potential 14 100.00 Very High Very High Very High
Nerve growth factor 500 99.78 Very High Very High Very High
substance P 37 99.56 Very High Very High Very High
dorsal root ganglion 60 99.50 Very High Very High Very High
trigeminal ganglion 295 99.04 Very High Very High Very High
antagonist 7 98.98 Very High Very High Very High
narcan 8 94.64 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 365 99.50 Very High Very High Very High
Nociception 44 95.84 Very High Very High Very High
Injury 116 94.96 High High
Impaired Glucose Tolerance 3 94.32 High High
Hypothermia 3 89.52 High High
Hyperalgesia 35 87.32 High High
Body Weight 2 85.52 High High
Pain 24 83.48 Quite High
Headache 31 80.72 Quite High
Hypersensitivity 10 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histidyl-proline diketopiperazine, a metabolite of TRH, was without effect on the hypothermic response of CAP and NVA.
Regulation (response) of CAP associated with qutenza
1) Confidence 0.27 Published 1986 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3087304 Disease Relevance 0.17 Pain Relevance 0.68
(but not SP i.t.). 2) A SP antagonist, (D-Pro2, D-Phe7, D-Trp9)-SP, did not reverse the effect of Cap or Dyn given i.t., even though it antagonized the effect of SP.
Regulation (effect) of Cap associated with qutenza, antagonist and substance p
2) Confidence 0.19 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1374471 Disease Relevance 0 Pain Relevance 2.15
min of NST addition, we verified a stabilized effect on the CAP amplitude.
Regulation (effect) of CAP associated with action potential
3) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2952823 Disease Relevance 0.25 Pain Relevance 0.83
In isolated islets, the insulin secretory response to glucose (20 mmol/l), carbachol (0.1 mmol/l), or phentolamine (0.5 mmol/l) was not affected after Cap.
Neg (not) Regulation (affected) of Cap associated with qutenza
4) Confidence 0.14 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943418 Disease Relevance 0.24 Pain Relevance 1.00
The present study was designed to determine the effects of various levels of capsaicin (CAP) on endurance capacity in forty-nine male Sprague-Dawley rats, aged 4 weeks, which were assigned to four groups.
Spec (determine) Regulation (effects) of CAP associated with qutenza
5) Confidence 0.11 Published 2003 Journal Br. J. Nutr. Section Abstract Doc Link 13129456 Disease Relevance 0.15 Pain Relevance 0.42
To determine to what extent the enhancement of CAP-evoked CGRP release in response to growth factor treatment might derive from increased neuronal survival and/or up-regulation in the proportion of neurons expressing TRPV1, release data were normalized to the number of TRPV1-immunoreactive neurons (Fig. 8B; TRPV1 neuron proportions shown in Table 1).
Regulation (regulation) of CAP in neuron associated with qutenza and calcitonin gene-related peptide
6) Confidence 0.02 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.59
In cultured DRG neurons, GDNF increases CAP sensitivity and TRPV1 expression [16,26] and increases neuropeptide content [16].
Regulation (sensitivity) of CAP in neurons associated with dorsal root ganglion, qutenza and neuropeptide
7) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.83 Pain Relevance 1.61
Hence, our findings suggest that NGF increases CAP responsiveness in individual cultured TG neurons.
Regulation (responsiveness) of CAP in neurons associated with qutenza, nerve growth factor and trigeminal ganglion
8) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.27 Pain Relevance 1.04
After normalization, BDNF treatment had no significant effect on CAP-evoked CGRP release at 1 or 100 ng/ml and actually reduced the amount of release at 10 ng/ml.
Neg (no) Regulation (effect) of CAP associated with qutenza and calcitonin gene-related peptide
9) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.25
This suggests that the pharmacology of CAP, AEA and ACEA at TRPV1, at least with respect to neuropeptide secretion, is similarly regulated in the presence of either of these growth factors.
Regulation (regulated) of CAP associated with qutenza and neuropeptide
10) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 1.09 Pain Relevance 1.42

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox