INT85348

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.81
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOA) mitochondrion (RHOA) cell morphogenesis (RHOA)
intracellular (RHOA) GTPase activity (RHOA) cytoplasm (RHOA)
Anatomy Link Frequency
smooth muscle 3
platelet 1
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 164 99.82 Very High Very High Very High
Serotonin 6 97.50 Very High Very High Very High
cytokine 96 97.28 Very High Very High Very High
Chronic pancreatitis 2 97.12 Very High Very High Very High
imagery 49 93.52 High High
lidocaine 1 90.48 High High
local anesthetic 8 89.84 High High
Potency 1 88.84 High High
Inflammation 147 80.68 Quite High
Angina 3 54.48 Quite High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 238 100.00 Very High Very High Very High
Infection 104 100.00 Very High Very High Very High
Metastasis 44 98.20 Very High Very High Very High
Cancer 180 98.00 Very High Very High Very High
Pancreatitis 2 97.12 Very High Very High Very High
Adenocarcinoma 53 92.52 High High
Hypersensitivity 12 91.48 High High
Injury 2 90.56 High High
Increased Venous Pressure Under Development 5 89.52 High High
Colon Cancer 5 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Atorvastatin/celecoxib combination also selectively modified membrane localization of small G-proteins, such as RhoA, RhoB and RhoC, which may contribute to the anti-cancer effects.
Localization (localization) of RhoA associated with cancer
1) Confidence 0.59 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18172863 Disease Relevance 0.58 Pain Relevance 0.05
Western blot analysis revealed that tetracaine prevented the membrane translocation of PLD-activating factors, ADP-ribosylation factor, RhoA, and protein kinase Calpha.
Localization (translocation) of RhoA
2) Confidence 0.58 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10591142 Disease Relevance 0 Pain Relevance 0.73
and to G12/RhoA activation to independently regulate platelet activation (aggregation and secretion) and platelet shape change responses, respectively [1,8].
Localization (secretion) of RhoA in platelet
3) Confidence 0.53 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.07 Pain Relevance 0.03
-mediated aggregation and secretion and the G12/Rho-mediated shape change while cGMP/PKG signaling inhibits the former Gq/Ca2+ dependent mechanism but does not affect the latter RhoA/Ca2+ independent mechanism [35].
Localization (secretion) of G12/Rho
4) Confidence 0.53 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
For monitoring localized small Rho GTPase activities (Cdc42, Rac1, RhoA) in cells, YFP-Raichu-CFP probes have been reported previously [70].
Localization (localized) of RhoA
5) Confidence 0.35 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.09 Pain Relevance 0.05
In each of these studies RhoA, Rac1 and Cdc42 were not significantly altered nor were they associated with aggressive or metastatic disease.
Neg (not) Localization (altered) of RhoA associated with metastasis
6) Confidence 0.24 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.50 Pain Relevance 0.19
The level of endothelin-converting enzyme was upregulated at that site where, upon exposure to serotonin, there were also increases in p47(phox), ROS, and ET-1 fluorescence intensities, and myosin light chain phosphorylation and RhoA activation were detected.
Localization (activation) of RhoA associated with serotonin
7) Confidence 0.24 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.65 Pain Relevance 0.19
This data suggested that the factors released during KSHV infection up-regulated RhoA-GTPase in the adhering cells.
Localization (released) of RhoA associated with herpes simplex virus and infection
8) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.74 Pain Relevance 0
RhoA protein levels are increased, and acetylcholine-induced translocation of RhoA to the plasma membrane is significantly higher in bronchial smooth muscle from airway hyperresponsive versus control rats [70,198].
Localization (translocation) of RhoA in smooth muscle
9) Confidence 0.18 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.25 Pain Relevance 0.07
In line with these observations, cholinergic agonist-induced RhoA translocation to the membrane, RhoA-mediated Ca2+ sensitization, and contraction are increased in bronchial smooth muscle from rats and mice exposed to repeated allergen challenge [45,48,49].
Localization (translocation) of RhoA in smooth muscle associated with agonist
10) Confidence 0.17 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.31 Pain Relevance 0.17
In line with these observations, cholinergic agonist-induced RhoA translocation to the membrane, RhoA-mediated Ca2+ sensitization, and contraction are increased in bronchial smooth muscle from rats and mice exposed to repeated allergen challenge [45,48,49].
Localization (translocation) of RhoA in smooth muscle associated with agonist
11) Confidence 0.16 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.31 Pain Relevance 0.17
, have been identified as contributors to increased RhoA abundance [47].
Localization (abundance) of RhoA
12) Confidence 0.15 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.32 Pain Relevance 0.18

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