INT85363

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Context Info
Confidence 0.51
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.48
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (JMJD6) nucleoplasm (JMJD6) oxidoreductase activity (JMJD6)
RNA binding (JMJD6) nucleolus (JMJD6) mRNA processing (JMJD6)
Anatomy Link Frequency
spinal 1
JMJD6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 16 99.68 Very High Very High Very High
intrathecal 6 79.76 Quite High
Spinal cord 2 71.72 Quite High
Disease Link Frequency Relevance Heat
Spasticity 6 98.96 Very High Very High Very High
Spinal Cord Injury 2 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes in spinal reflexes, with a large reduction in spasticity, no change in motoneurone excitability and a large decrease in PSR, suggest that clonidine acts at a premotoneuronal level, possibly by presynaptic inhibition of group II fibres.
Negative_regulation (decrease) of PSR in spinal associated with spasticity and clonidine
1) Confidence 0.51 Published 1999 Journal Exp Brain Res Section Abstract Doc Link 10591914 Disease Relevance 0.23 Pain Relevance 0.63
Clonidine administration decreased the amplitude of the early PSR (90-120 ms, N=4) and the threshold and maximal integrated EMG corresponding to the late response (140-450 ms, N=7).
Negative_regulation (decreased) of PSR associated with clonidine
2) Confidence 0.38 Published 1999 Journal Exp Brain Res Section Abstract Doc Link 10591914 Disease Relevance 0.24 Pain Relevance 0.79

General Comments

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