INT85378

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.81
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pdss1)
Anatomy Link Frequency
spinal 1
blood 1
Pdss1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 5 99.84 Very High Very High Very High
Inflammation 65 99.52 Very High Very High Very High
Neuropeptide 1 98.56 Very High Very High Very High
antinociception 2 98.14 Very High Very High Very High
cytokine 2 96.80 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 4 94.36 High High
Arthritis 1 81.92 Quite High
intrathecal 2 80.68 Quite High
Antinociceptive 3 76.48 Quite High
Central nervous system 2 63.04 Quite High
Disease Link Frequency Relevance Heat
Angina 5 99.84 Very High Very High Very High
INFLAMMATION 65 99.52 Very High Very High Very High
Toxicity 7 94.08 High High
Recurrence 1 90.32 High High
Mitochondrial Encephalomyopathies 1 89.52 High High
Cardiovascular Disease 2 84.28 Quite High
Syndrome 25 83.72 Quite High
Diabetes Mellitus 3 82.72 Quite High
Arthritis 1 81.92 Quite High
Infantile Spasms 1 81.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems that the presence of TpT in unstable angina patients' blood may be an important factor characterizing patients with more serious prognosis.
TpT Binding (presence) of in blood associated with angina
1) Confidence 0.28 Published 1999 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 10592726 Disease Relevance 0.63 Pain Relevance 0.55
Nine genes are presumed to be involved in CoQ10 biosynthesis, and as of now, mutations in three genes have been shown to result in primary CoQ10 deficiency: PDSS1, PDSS2, and COQ2.21 Duncan and colleagues found an autosomal recessive form of neonatal-onset primary coenzyme Q10 deficiency resulting from a nonsense mutation in COQ9.24
PDSS1 Binding (found) of
2) Confidence 0.26 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.96 Pain Relevance 0.06
Together, these results indicate that bis-selenide produces antinociception at spinal sites through the activation of ATP-sensitive and voltage-gated K(+) channels and interaction with kainate and trans-ACDP receptors as well as vanilloid and neuropeptide receptors and pro-inflammatory cytokines.
trans-ACDP Binding (interaction) of in spinal associated with antinociception, inflammation, neuropeptide and cytokine
3) Confidence 0.04 Published 2008 Journal Brain Res. Section Abstract Doc Link 18680735 Disease Relevance 0.27 Pain Relevance 0.45
These data show that an ethanolic solution of PCE reduces inflammation to a similar extent as indomethacin or trans-resveratrol.
trans-resveratrol Binding (indomethacin) of associated with inflammation
4) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2267461 Disease Relevance 0.92 Pain Relevance 0.16
Chemical analysis from Supplemental Health Formulations reported that the trans-resveratrol complex was at least 500 mg/g and emodin content was < 20 mg/g.
trans-resveratrol Binding (complex) of
5) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2267461 Disease Relevance 0.29 Pain Relevance 0.09
Nevertheless, another finding which suggests that there may also be individual patient factors which could affect the occurrence of PDSS is the fact that one patient in the clinical trials experienced this event twice.
PDSS Binding (occurrence) of
6) Confidence 0.02 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2895589 Disease Relevance 0.73 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox