INT85388

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Context Info
Confidence 0.25
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 3.74
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spine 3
fat 2
skeleton 1
body 1
Bmc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 124 96.76 Very High Very High Very High
anesthesia 2 91.72 High High
Pain 4 78.72 Quite High
cytokine 48 56.20 Quite High
Inflammation 109 50.00 Quite Low
fibrosis 11 27.48 Quite Low
agonist 38 5.00 Very Low Very Low Very Low
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
dexamethasone 20 5.00 Very Low Very Low Very Low
Potency 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 164 99.16 Very High Very High Very High
Arthritis 254 97.16 Very High Very High Very High
Body Weight 40 96.84 Very High Very High Very High
Hypercalcemia 25 95.48 Very High Very High Very High
Death 1 87.08 High High
Osteitis 1 83.32 Quite High
Hypocalcemia 1 80.08 Quite High
Muscle Weakness 1 79.48 Quite High
Stress 19 79.12 Quite High
Pain 4 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During pregnancy, BMC and area of the total skeleton increased significantly in pregnant rats, but the changes in BMD were not different compared with the control group.
Positive_regulation (increased) of BMC in skeleton
1) Confidence 0.25 Published 1999 Journal Bone Section Abstract Doc Link 10593413 Disease Relevance 0.17 Pain Relevance 0.09
Actually, the frequency of pathological finding of the BMC, radiographic signs of ostemalacia and osteoporosis were not significantly reduced, but mean BMC was significantly increased.
Positive_regulation (increased) of BMC associated with osteoporosis
2) Confidence 0.08 Published 1994 Journal Srp Arh Celok Lek Section Abstract Doc Link 17977409 Disease Relevance 0.64 Pain Relevance 0.08
Again, a consistent increase was seen in BMC with marrow ablation, although none of the SB431542 treated groups showed a significant increase in BMC compared to DMSO controls (Figure 2B).
Positive_regulation (increase) of BMC
3) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.09 Pain Relevance 0
The management of these patients with anabolic agents, recombinant growth hormone or oxandrolone, a synthetic testosterone analogue, results in a significant increase in total body or lumbar spine BMC (T-BMC or LS-BMC, respectively), but no increase in LS- spine BMD.
Positive_regulation (increase) of BMC in spine
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958849 Disease Relevance 0.21 Pain Relevance 0.03
The increase in BMC but not BMD implies a proportionate increase in bone area in patients treated with these anabolic agents.
Positive_regulation (increase) of BMC
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958849 Disease Relevance 0.20 Pain Relevance 0.03
The management of these patients with anabolic agents, recombinant growth hormone or oxandrolone, a synthetic testosterone analogue, results in a significant increase in total body or lumbar spine BMC (T-BMC or LS-BMC, respectively), but no increase in LS- spine BMD.
Positive_regulation (increase) of BMC in spine
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958849 Disease Relevance 0.20 Pain Relevance 0.03
The management of these patients with anabolic agents, recombinant growth hormone or oxandrolone, a synthetic testosterone analogue, results in a significant increase in total body or lumbar spine BMC (T-BMC or LS-BMC, respectively), but no increase in LS- spine BMD.
Positive_regulation (increase) of BMC in spine
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958849 Disease Relevance 0.20 Pain Relevance 0.03
In normal controls, BMC and fat mass ratio increased notably over the study duration, whereas a limited increase in BMC (Figure 6a) and a stagnation of fat mass (Figure 6b) were observed in arthritic AIA controls.
Positive_regulation (increased) of BMC in fat associated with arthritis
8) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 0.77 Pain Relevance 0.14
In normal controls, BMC and fat mass ratio increased notably over the study duration, whereas a limited increase in BMC (Figure 6a) and a stagnation of fat mass (Figure 6b) were observed in arthritic AIA controls.
Positive_regulation (increase) of BMC in fat associated with arthritis
9) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 0.78 Pain Relevance 0.14
Nevertheless, the positive changes in biomarkers of bone formation in the present study have not translated to increases in BMD and BMC.
Positive_regulation (increases) of BMC
10) Confidence 0.01 Published 2005 Journal Nutr J Section Body Doc Link PMC554088 Disease Relevance 0.30 Pain Relevance 0
As for an effect of soy isoflavones alone, Chen et al. [56] recently reported that supplementing postmenopausal women with soy isoflavones (40 and 80 mg/d) for one year resulted in favorable increases in BMC of the hip in women who are at least four years postmenopausal and are of low body weight or have low levels of dietary calcium.
Positive_regulation (increases) of BMC in body associated with body weight
11) Confidence 0.01 Published 2005 Journal Nutr J Section Body Doc Link PMC554088 Disease Relevance 0.17 Pain Relevance 0

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