INT8539

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 12.65
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina1a) extracellular region (Serpina1a)
Anatomy Link Frequency
PMN 5
liver 2
lung 2
macrophage 1
head 1
Serpina1a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 29 99.84 Very High Very High Very High
cva 6 99.74 Very High Very High Very High
anesthesia 2 99.46 Very High Very High Very High
abdominal pain 7 99.44 Very High Very High Very High
cINOD 9 99.08 Very High Very High Very High
palliative 2 98.52 Very High Very High Very High
peptic ulcer disease 2 98.32 Very High Very High Very High
imagery 5 94.24 High High
headache 4 80.24 Quite High
Inflammation 56 75.00 Quite High
Disease Link Frequency Relevance Heat
Rupture 10 99.90 Very High Very High Very High
Injury 15 99.88 Very High Very High Very High
Emphysema 59 99.84 Very High Very High Very High
Pressure And Volume Under Development 2 99.78 Very High Very High Very High
Cv General 3 Under Development 6 99.74 Very High Very High Very High
Aneurism 10 99.66 Very High Very High Very High
Abdominal Pain 7 99.44 Very High Very High Very High
Cirrhosis 3 99.28 Very High Very High Very High
Hepatotoxicity 2 99.20 Very High Very High Very High
Urological Neuroanatomy 39 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further testing by a pulmonary specialist confirmed diagnosis of emphysema secondary to a deficiency of Alpha-1 Antitrypsin (AAT).
Negative_regulation (deficiency) of Alpha-1 Antitrypsin associated with emphysema
1) Confidence 0.58 Published 2001 Journal Clin Lab Sci Section Abstract Doc Link 11760819 Disease Relevance 0.80 Pain Relevance 0.23
We present a rare case of a patient who presented with acute abdominal pain with a previous history of alpha-1-antitrypsin deficiency (alpha1-antitrypsin deficiency).
Negative_regulation (deficiency) of alpha-1-antitrypsin associated with abdominal pain
2) Confidence 0.56 Published 2010 Journal J. Vasc. Surg. Section Abstract Doc Link 20570466 Disease Relevance 0.43 Pain Relevance 0.18
Redo lung volume reduction surgery in a patient with alpha1-antitrypsin deficiency.
Negative_regulation (deficiency) of alpha1-antitrypsin in lung
3) Confidence 0.44 Published 2000 Journal Ann. Thorac. Surg. Section Title Doc Link 10735720 Disease Relevance 0.28 Pain Relevance 0.10
A 52-year-old-white male underwent double lung transplantation for severe emphysema due to alpha-1-antitrypsin deficiency and heavy tobacco use.
Negative_regulation (deficiency) of alpha-1-antitrypsin in lung associated with emphysema
4) Confidence 0.42 Published 2002 Journal Transpl Infect Dis Section Abstract Doc Link 12123425 Disease Relevance 1.33 Pain Relevance 0.08
Only two patients required surgery on the contralateral side after 4.5 and 6 months, respectively, both suffering from alpha-1-antitrypsin deficiency.
Negative_regulation (deficiency) of alpha-1-antitrypsin
5) Confidence 0.42 Published 2001 Journal Eur J Cardiothorac Surg Section Body Doc Link 11574206 Disease Relevance 0 Pain Relevance 0
A three year old child with cirrhosis of the liver and ascites caused by alpha-1-antitrypsin deficiency, developed severe abdominal pain with diarrhea and fever.
Negative_regulation (deficiency) of alpha-1-antitrypsin in liver associated with pressure and volume under development, abdominal pain, diarrhoea, cirrhosis and fever
6) Confidence 0.42 Published 1982 Journal Monatsschr Kinderheilkd Section Abstract Doc Link 6981063 Disease Relevance 1.04 Pain Relevance 0.10
The association between mesenteric arterial aneurysm rupture and alpha-1-antitrypsin deficiency is explored.
Negative_regulation (deficiency) of alpha-1-antitrypsin associated with rupture and cva
7) Confidence 0.41 Published 2010 Journal J. Vasc. Surg. Section Abstract Doc Link 20570466 Disease Relevance 0.63 Pain Relevance 0.18
We present a rare case of a patient who presented with acute abdominal pain with a previous history of alpha-1-antitrypsin deficiency (alpha1-antitrypsin deficiency).
Negative_regulation (deficiency) of alpha1-antitrypsin associated with abdominal pain
8) Confidence 0.41 Published 2010 Journal J. Vasc. Surg. Section Abstract Doc Link 20570466 Disease Relevance 0.44 Pain Relevance 0.18
We present a rare case of a patient who presented with acute abdominal pain with a previous history of alpha-1-antitrypsin deficiency (alpha1-antitrypsin deficiency).
Negative_regulation (deficiency) of alpha1-antitrypsin associated with abdominal pain
9) Confidence 0.41 Published 2010 Journal J. Vasc. Surg. Section Abstract Doc Link 20570466 Disease Relevance 0.44 Pain Relevance 0.18
Successful endovascular treatment of multiple mesenteric arterial aneurysms associated with alpha-1-antitrypsin deficiency.
Negative_regulation (deficiency) of alpha-1-antitrypsin associated with aneurism
10) Confidence 0.41 Published 2010 Journal J. Vasc. Surg. Section Title Doc Link 20570466 Disease Relevance 0.46 Pain Relevance 0.18
Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency.
Negative_regulation (deficiency) of alpha-1-antitrypsin in liver associated with injury and hepatotoxicity
11) Confidence 0.32 Published 2006 Journal Hepatology Section Title Doc Link 17006946 Disease Relevance 1.05 Pain Relevance 0.14
Hereditary alpha 1-antitrypsin (alpha 1-AT) deficiency has been suggested to be associated with peptic ulcer disease.
Negative_regulation (deficiency) of alpha 1-antitrypsin associated with peptic ulcer disease and disease
12) Confidence 0.19 Published 1988 Journal Digestion Section Abstract Doc Link 3260879 Disease Relevance 0.41 Pain Relevance 0.10
The only significant changes seen after premedication, during anesthesia and during surgery were a decrease in serum concentrations of alpha 1-antitrypsin and haptoglobin.
Negative_regulation (decrease) of alpha 1-antitrypsin associated with anesthesia
13) Confidence 0.02 Published 1992 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 1374604 Disease Relevance 0.81 Pain Relevance 0.10
[The effects of prostaglandin E1 on myeloperoxidase and alpha 1-protease inhibitor in head-neck surgery].
Negative_regulation (inhibitor) of alpha 1-protease in head
14) Confidence 0.01 Published 1991 Journal Masui Section Title Doc Link 1662729 Disease Relevance 0.22 Pain Relevance 0.08
Supernatants, obtained from normal neutrophil polymorphonuclear leukocytes (PMN), challenged with opsonized zymosan (OPZ), were found to inactivate the PMN elastase inhibitor, alpha 1-proteinase inhibitor (A1PI).
Negative_regulation (inhibitor) of A1PI in PMN
15) Confidence 0.00 Published 1993 Journal Respiration Section Abstract Doc Link 8385794 Disease Relevance 0.20 Pain Relevance 0.18
Supernatants from normal PMN triggered by OPZ in the presence of inhibitors of the myeloperoxidase (MPO) system as well as supernatants from MPO-deficient PMN were inactive but displayed the capacity of inactivating A1PI after treatment with the metalloproteinases activator 4-aminophenylmercuric acetate.
Negative_regulation (inactivating) of A1PI in PMN associated with metalloproteinase and urological neuroanatomy
16) Confidence 0.00 Published 1993 Journal Respiration Section Abstract Doc Link 8385794 Disease Relevance 0.63 Pain Relevance 0.29
As PMN-derived HOCl is well known to inactivate A1PI directly, through a process previously shown to be inhibitable by NMS, the present results suggest: (1) both the oxidative and proteolytic inactivation of A1PI depend on the HOCl-generating MPO system; (2) the tissue-destructive activity of PMN elastase could be controlled by interfering pharmacologically with the PMN-MPO system, directly and indirectly responsible for the breakdown of the tissue antielastase screen.
Negative_regulation (inactivate) of A1PI in PMN associated with neuroleptic malignant syndrome and urological neuroanatomy
17) Confidence 0.00 Published 1993 Journal Respiration Section Abstract Doc Link 8385794 Disease Relevance 0.89 Pain Relevance 0.29
The MPO-dependent autoactivation of latent metalloenzymes by PMN, with consequent A1PI inactivation, was inhibited by the nonsteroidal anti-inflammatory drug nimesulide (NMS).
Negative_regulation (inactivation) of A1PI in PMN associated with inflammation, neuroleptic malignant syndrome, cinod and urological neuroanatomy
18) Confidence 0.00 Published 1993 Journal Respiration Section Abstract Doc Link 8385794 Disease Relevance 0.79 Pain Relevance 0.30
As the supernatants were treated with methionine to quench residual oxidants, primarily chloramines, the observed inactivation of A1PI appears to be due to enzymes.
Negative_regulation (inactivation) of A1PI
19) Confidence 0.00 Published 1993 Journal Respiration Section Abstract Doc Link 8385794 Disease Relevance 0.22 Pain Relevance 0.19
As PMN-derived HOCl is well known to inactivate A1PI directly, through a process previously shown to be inhibitable by NMS, the present results suggest: (1) both the oxidative and proteolytic inactivation of A1PI depend on the HOCl-generating MPO system; (2) the tissue-destructive activity of PMN elastase could be controlled by interfering pharmacologically with the PMN-MPO system, directly and indirectly responsible for the breakdown of the tissue antielastase screen.
Negative_regulation (inactivation) of A1PI in PMN associated with neuroleptic malignant syndrome and urological neuroanatomy
20) Confidence 0.00 Published 1993 Journal Respiration Section Abstract Doc Link 8385794 Disease Relevance 0.86 Pain Relevance 0.27

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox