INT85403

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 3.07
Pain Relevance 4.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck) DNA binding (Cck)
Anatomy Link Frequency
neurons 6
Cck (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 138 100.00 Very High Very High Very High
Neuropeptide 14 100.00 Very High Very High Very High
Cannabinoid 16 94.20 High High
Spinal cord 18 93.36 High High
Pain 32 90.40 High High
nociceptor 42 90.16 High High
Migraine 6 88.20 High High
Cannabinoid receptor 4 87.08 High High
Inflammation 12 86.08 High High
GABAergic 8 75.20 Quite High
Disease Link Frequency Relevance Heat
Nociception 18 93.60 High High
Pain 32 90.40 High High
Headache 6 88.20 High High
INFLAMMATION 12 86.08 High High
Cognitive Disorder 2 83.36 Quite High
Anorexia 6 83.04 Quite High
Obesity 6 73.08 Quite High
Hyperphagia 6 72.60 Quite High
Neuropathic Pain 6 49.68 Quite Low
Repression 6 30.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preprocholecystokinin (ppCCK) mRNA is robustly expressed in the LPBS compared to other subnuclei of the PB in which the ppCCK transcript is only expressed in moderate to few numbers of neurons [27].
Transcription (expressed) of ppCCK in neurons
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.23
Further analyses revealed that at least a subset of the activated neurons in the LPBS expressed CCK mRNA and in the VMH expressed transcripts for CCK receptors.
Transcription (expressed) of CCK in neurons associated with cholecystokinin
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.74 Pain Relevance 0.77
We performed a double in situ hybridization study to detect mRNA of CB1 in combination with mRNA of glutamic acid decarboxylase 65k, neuropeptide cholecystokinin (CCK), parvalbumin, calretinin and calbindin D28k, respectively.
Transcription (detect) of cholecystokinin associated with neuropeptide and cholecystokinin
3) Confidence 0.52 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10594647 Disease Relevance 0.17 Pain Relevance 0.54
We performed a double in situ hybridization study to detect mRNA of CB1 in combination with mRNA of glutamic acid decarboxylase 65k, neuropeptide cholecystokinin (CCK), parvalbumin, calretinin and calbindin D28k, respectively.
Transcription (detect) of CCK associated with neuropeptide and cholecystokinin
4) Confidence 0.51 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10594647 Disease Relevance 0.17 Pain Relevance 0.54
Further analyses revealed that at least a subset of the activated neurons in the LPBS expressed CCK mRNA and in the VMH expressed transcripts for CCK receptors.
Transcription (expressed) of CCK in neurons associated with cholecystokinin
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.73 Pain Relevance 0.77
In addition, noxious chemical stimulation of the rat hindpaw was also reported to activate LPBS neurons, almost all of which expressed ppCCK transcripts [27].
Transcription (expressed) of ppCCK in neurons
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.54 Pain Relevance 0.86
Preprocholecystokinin (ppCCK) mRNA is robustly expressed in the LPBS compared to other subnuclei of the PB in which the ppCCK transcript is only expressed in moderate to few numbers of neurons [27].
Transcription (expressed) of ppCCK in neurons
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0 Pain Relevance 0.24
Further analyses revealed that at least a subset of the activated neurons in the LPBS expressed CCK mRNA and in the VMH expressed transcripts for CCK receptors.
Transcription (transcripts) of CCK in neurons associated with cholecystokinin
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978708 Disease Relevance 0.73 Pain Relevance 0.76

General Comments

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