INT85404

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Context Info
Confidence 0.72
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 3.15
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
spinal cord 1
brain 1
Dendritic cells 1
caudate putamen 1
hippocampus 1
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 31 100.00 Very High Very High Very High
dopamine receptor 16 100.00 Very High Very High Very High
Dopamine 38 99.84 Very High Very High Very High
Neuropeptide 5 99.80 Very High Very High Very High
alcohol 37 99.64 Very High Very High Very High
Cannabinoid 198 99.60 Very High Very High Very High
Hippocampus 46 99.48 Very High Very High Very High
cytokine 3 98.84 Very High Very High Very High
GABAergic 40 98.68 Very High Very High Very High
Neuropathic pain 11 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 11 98.64 Very High Very High Very High
Sprains And Strains 12 98.16 Very High Very High Very High
Bordatella Infection 2 95.56 Very High Very High Very High
Infection 1 91.88 High High
Targeted Disruption 36 86.72 High High
Pain 5 83.72 Quite High
Nociception 3 83.68 Quite High
Cognitive Disorder 17 83.36 Quite High
INFLAMMATION 1 83.00 Quite High
Primary Sclerosing Cholangitis 1 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We performed a double in situ hybridization study to detect mRNA of CB1 in combination with mRNA of glutamic acid decarboxylase 65k, neuropeptide cholecystokinin (CCK), parvalbumin, calretinin and calbindin D28k, respectively.
Transcription (detect) of CB1 associated with neuropeptide and cholecystokinin
1) Confidence 0.72 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10594647 Disease Relevance 0.17 Pain Relevance 0.51
CB1 mRNA expression is induced by activity
Transcription (expression) of CB1
2) Confidence 0.71 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.22 Pain Relevance 0
In particular, CB1 protein and mRNA are present at very high levels in cortical GABAergic interneurons (those that release ?
Transcription (present) of CB1 protein in interneurons associated with gabaergic
3) Confidence 0.69 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.16 Pain Relevance 0.72
In the same samples, we found that both RUN and ENR increased the expression of CB1 receptor mRNA in the hippocampus (Fig. 5C; CTR vs.
Transcription (expression) of CB1 receptor in hippocampus associated with hippocampus
4) Confidence 0.68 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.21 Pain Relevance 0.05
These researchers also reported that at least in the strain of rats bred for its ethanol preference, the Marchigian-Sardinian alcohol-preferring rats, CB1 cannabinoid receptor mRNA expression was increased in brain areas relevant for processing reward and reward-associated behavior, suggesting that alterations in the function of the CB1 receptor system may be linked to genetic vulnerability to alcohol misuse (Cippitelli et al 2005).
Transcription (expression) of CB1 in brain associated with cannabinoid receptor, sprains and strains and alcohol
5) Confidence 0.68 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656312 Disease Relevance 0.42 Pain Relevance 0.61
Background density was subtracted from the CB1R band density and normalized to ?
Transcription (subtracted) of CB1R in band
6) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.08 Pain Relevance 0.07
To evaluate CB1 mRNA expression changes by activity, we subjected additional 5 female C57Bl/6 to either experimental condition (RUN, ENR, CTR).
Transcription (expression) of CB1
7) Confidence 0.53 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.13 Pain Relevance 0
ISH revealed significantly lower levels of CB1 mRNA in the ventromedial hypothalamus (VMH) and the caudate putamen (Cpu) of the nNOS-KO animals, compared with WT mice.
Transcription (levels) of CB1 in caudate putamen
8) Confidence 0.51 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11168564 Disease Relevance 0.13 Pain Relevance 0.32
Therefore, in situ hybridization (ISH) experiments were performed in the adult murine brain to determine possible changes in CB1 mRNA levels in nNOS-KO, compared with WT mice, and to reveal brain areas where CB1 and nNOS were coexpressed in the same neurons.
Transcription (levels) of CB1 in neurons
9) Confidence 0.51 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11168564 Disease Relevance 0.17 Pain Relevance 0.28
Dendritic cells expressed mRNA for cannabinoid receptor 1 (CB(1)), cannabinoid CB(2) receptor, and vanilloid receptor 1 (TRPV1) and the addition of the G(i) inhibitor, pertussis toxin, completely attenuated suppression induced by 3 and 6 muM THC but not by 10 muM THC.
Transcription (expressed) of cannabinoid receptor 1 in Dendritic cells associated with bordatella infection, cannabinoid receptor, cannabinoid and delta-9-tetrahydrocannabinol
10) Confidence 0.29 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443217 Disease Relevance 0.26 Pain Relevance 0.81
The goal of this study was to evaluate whether the disruption of CB1 cannabinoid receptor gene modulates the changes induced by neuropathic pain in the expression of mu- (MOR), delta- (DOR) and kappa-opioid receptors (KOR) mRNA levels in the DRG and spinal cord.
Transcription (disruption) of CB1 cannabinoid receptor gene in DRG associated with cannabinoid receptor, kappa opioid receptor, neuropathic pain and spinal cord
11) Confidence 0.22 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16360182 Disease Relevance 0.52 Pain Relevance 0.68
The aim of this study was to determine at which developmental stage and how dopamine regulates the expression of striatal dopamine receptor and neuropeptide mRNAs.
Transcription (expression) of striatal dopamine receptor in developmental stage associated with dopamine, dopamine receptor and neuropeptide
12) Confidence 0.12 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998124 Disease Relevance 0.07 Pain Relevance 0.39
These findings bring new insights to the critical influence of dopamine on the expression of striatal dopamine receptor and neuropeptide mRNAs during development, and suggest that mesostriatal dopamine transmission functions from G14 on.
Transcription (expression) of striatal dopamine receptor associated with dopamine, dopamine receptor and neuropeptide
13) Confidence 0.12 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998124 Disease Relevance 0.07 Pain Relevance 0.60
The goal of this study was to evaluate whether the disruption of CB1 cannabinoid receptor gene modulates the changes induced by neuropathic pain in the expression of mu- (MOR), delta- (DOR) and kappa-opioid receptors (KOR) mRNA levels in the DRG and spinal cord.
Transcription (disruption) of CB1 cannabinoid receptor gene in spinal cord associated with cannabinoid receptor, kappa opioid receptor, neuropathic pain and spinal cord
14) Confidence 0.07 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16360182 Disease Relevance 0.52 Pain Relevance 0.68

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