INT8541

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Context Info
Confidence 0.76
First Reported 1990
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 23.72
Pain Relevance 6.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Csrp1)
Anatomy Link Frequency
joint 5
erythrocyte 2
eosinophil 2
Plasma 1
thorax 1
Csrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 14 99.92 Very High Very High Very High
rheumatoid arthritis 29 99.78 Very High Very High Very High
Pain 16 99.30 Very High Very High Very High
Inflammatory marker 1 98.78 Very High Very High Very High
Infliximab 4 98.32 Very High Very High Very High
depression 2 97.96 Very High Very High Very High
ischemia 9 97.76 Very High Very High Very High
Migraine 11 97.60 Very High Very High Very High
Inflammation 31 97.20 Very High Very High Very High
Demyelination 2 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 25 100.00 Very High Very High Very High
Skin Cancer 2 100.00 Very High Very High Very High
Rheumatoid Arthritis 51 99.92 Very High Very High Very High
Rheumatic Diseases 2 99.36 Very High Very High Very High
Echinococcosis 40 99.28 Very High Very High Very High
Adhesions 5 99.16 Very High Very High Very High
Crystal Associated Disease 4 98.96 Very High Very High Very High
Fever 6 98.92 Very High Very High Very High
Cv General 3 Under Development 15 98.68 Very High Very High Very High
INFLAMMATION 31 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ESR was mildly elevated to 18 mm/hr, but CRP was negative.
Neg (negative) Gene_expression (negative) of CRP
1) Confidence 0.76 Published 1998 Journal Rinsho Shinkeigaku Section Abstract Doc Link 10203979 Disease Relevance 0.68 Pain Relevance 0.10
Patients in the surgically treated groups (groups A and B) showed a significant reduction in the number of swollen and painful joints and in their ESR and serum CRP levels, and this effect was maintained for at least 3 years.
Gene_expression (levels) of CRP in joints associated with pain
2) Confidence 0.76 Published 2000 Journal Int Orthop Section Abstract Doc Link 11153450 Disease Relevance 0.38 Pain Relevance 0.25
CONCLUSION: Elevated levels of CRP and urea could indicate the severity of infection in patients with LA.
Gene_expression (levels) of CRP
3) Confidence 0.76 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 19836722 Disease Relevance 0.20 Pain Relevance 0
However, only CRP and urea were found to be significantly raised in the LA group.
Gene_expression (raised) of CRP
4) Confidence 0.66 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 19836722 Disease Relevance 0.23 Pain Relevance 0
No correlation was detected between flow-mediated dilatation and age, sex, serum lipids, CRP, ESR, smoking habits and disease activity scores.
Neg (No) Gene_expression (detected) of CRP
5) Confidence 0.66 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16204374 Disease Relevance 0.05 Pain Relevance 0
CRP was significantly higher in those patients with a major coronary event (1.71 +/- 1.11 versus 1.03 +/- 0.56%; p=0.048), but not in those with SMI (1.19 +/- 0.72 vs 1.09 +/- 0.67%; p=0.654).
Neg (not) Gene_expression (higher) of CRP associated with ischemia
6) Confidence 0.61 Published 2001 Journal Diabetes Metab. Section Abstract Doc Link 11240446 Disease Relevance 1.72 Pain Relevance 0.38
Higher plasma fibrinogen and CRP levels in the acute phase, longer BERA latency and I-III interval and increased gadolinium uptake in the vestibular nerve and Scarpa's ganglion on enhanced MRI confirm the inflammatory nature of the process.
Gene_expression (levels) of CRP in Scarpa's ganglion associated with ganglion cysts and inflammation
7) Confidence 0.53 Published 2005 Journal Rev Laryngol Otol Rhinol (Bord) Section Abstract Doc Link 16496559 Disease Relevance 1.24 Pain Relevance 0.45
The measures comprised swollen and tender joint counts (SJC, TJC), CRP, ESR, patient and evaluator global assessments of activity (PGA, EGA), and the Health Assessment Questionnaire Disability Index (HAQ).
Gene_expression (comprised) of CRP in joint
8) Confidence 0.51 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16522674 Disease Relevance 0 Pain Relevance 0
CRP is the most useful measure of disease activity and is frequently assessed in clinical trials to determine systemic improvement.
Gene_expression (assessed) of CRP associated with disease
9) Confidence 0.40 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 7685225 Disease Relevance 0.69 Pain Relevance 0.20
If doubt exists, however, tests may be necessary including FBC, ESR and CRP, uric acid for suspected gout and X-rays of the affected joints especially following trauma, or pseudogout.
Gene_expression (necessary) of CRP in joints associated with injury and crystal associated disease
10) Confidence 0.37 Published 2010 Journal Practitioner Section Abstract Doc Link 20198931 Disease Relevance 1.49 Pain Relevance 0.45
g mL-1) or collagen related peptide (CRP, 100 ?
Gene_expression (peptide) of CRP
11) Confidence 0.35 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.09 Pain Relevance 0
Spreading of HS1-/- platelets on CRP, collagen, fibrinogen or a combination of fibrinogen and thrombin was indistinguishable to that of wild type (WT) platelets both in terms of morphology and surface area (Figure 2A and2B).
Gene_expression (Spreading) of CRP in platelets
12) Confidence 0.35 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.06 Pain Relevance 0.05
In CRP-AM and CRP, the maximum negative slope of unipolar activation complexes was significantly depressed and activation-recovery intervals prolonged.
Gene_expression (prolonged) of CRP
13) Confidence 0.34 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14693684 Disease Relevance 0.45 Pain Relevance 0.11
In CRP-AM and CRP, the maximum negative slope of unipolar activation complexes was significantly depressed and activation-recovery intervals prolonged.
Gene_expression (prolonged) of CRP
14) Confidence 0.34 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14693684 Disease Relevance 0.45 Pain Relevance 0.11
Their BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and BASFI (Bath Ankylosing Spondylitis Functional Index) scores, ESR and CRP levels were recorded.
Gene_expression (levels) of CRP
15) Confidence 0.28 Published 2008 Journal Rheumatology (Oxford) Section Body Doc Link 18524805 Disease Relevance 0.09 Pain Relevance 0
With regard to study design, patients were identified retrospectively and our phenotypes were pre-defined using data that was available on all patients (thus ESR and CRP were used as surrogates for defining response rather than formal joint counts that were not available for all patients).
Gene_expression (used) of CRP in joint
16) Confidence 0.25 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.43 Pain Relevance 0.26
Fasting glucose, serum lipids, high sensitive CRP (hsCRP), ESR, asymmetric dimethylarginine (ADMA) and ET-1 were studied.
Gene_expression (studied) of CRP
17) Confidence 0.21 Published 2009 Journal Intern. Med. Section Body Doc Link 19687580 Disease Relevance 0.19 Pain Relevance 0
Fasting glucose, serum lipids, high sensitive CRP (hsCRP), ESR, asymmetric dimethylarginine (ADMA) and ET-1 were studied.
Gene_expression (studied) of hsCRP
18) Confidence 0.19 Published 2009 Journal Intern. Med. Section Body Doc Link 19687580 Disease Relevance 0.18 Pain Relevance 0
Gene expressions of cysteine-rich protein 1, metallothionein 2, and EST WD repeat domain 92 were reduced at LF 3?
Gene_expression (expressions) of cysteine-rich protein 1
19) Confidence 0.18 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC3017904 Disease Relevance 0.09 Pain Relevance 0
Higher plasma fibrinogen and CRP levels in the acute phase, longer BERA latency and I-III interval and increased gadolinium uptake in the vestibular nerve and Scarpa's ganglion on enhanced MRI confirm the inflammatory nature of the process.
Gene_expression (levels) of CRP in nerve associated with ganglion cysts and inflammation
20) Confidence 0.18 Published 2005 Journal Rev Laryngol Otol Rhinol (Bord) Section Abstract Doc Link 16496559 Disease Relevance 1.24 Pain Relevance 0.45

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