INT85417

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Context Info
Confidence 0.09
First Reported 2000
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 9.38
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
blood 6
macrophages 4
Th1 cells 2
osteoclast 2
T24 2
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 499 100.00 Very High Very High Very High
Inflammation 174 100.00 Very High Very High Very High
Sciatic nerve 3 100.00 Very High Very High Very High
rheumatoid arthritis 193 99.68 Very High Very High Very High
Inflammatory response 12 99.38 Very High Very High Very High
antagonist 7 99.30 Very High Very High Very High
Eae 4 98.12 Very High Very High Very High
Cannabinoid 6 95.76 Very High Very High Very High
interstitial cystitis 7 95.60 Very High Very High Very High
Osteoarthritis 35 87.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 184 100.00 Very High Very High Very High
Rheumatoid Arthritis 240 99.68 Very High Very High Very High
Bladder Cancer 1 99.60 Very High Very High Very High
Adhesions 5 98.80 Very High Very High Very High
Injury 16 98.12 Very High Very High Very High
Vasculitis 5 96.52 Very High Very High Very High
Interstitial Cystitis 7 95.60 Very High Very High Very High
Infection 174 95.52 Very High Very High Very High
Stress 90 95.08 Very High Very High Very High
Hypercalcemia 1 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean (±SD) differences in preferred directions of all neurons tested during upright and RED in the CW and CCW directions were 4.7° ± 2.7° and ?
Positive_regulation (tested) of Gene_expression (neurons) of RED in neurons
1) Confidence 0.09 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
Responses to the high frequency sound alone were enhanced by the presence of the low frequency sound (Fig. 6D, left side; red versus black curve, p<10?
Positive_regulation (enhanced) of Gene_expression (presence) of red
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861002 Disease Relevance 0 Pain Relevance 0
In this study, we examined the role of this nuclear factor on the induction of proinflammatory cytokine gene expression in human bladder carcinoma T24 cells and further examined their corresponding protein levels in the urine of IC patients.
Spec (examined) Positive_regulation (induction) of Gene_expression (expression) of cytokine in T24 associated with bladder cancer, interstitial cystitis and cytokine
3) Confidence 0.03 Published 2003 Journal Urol. Res. Section Abstract Doc Link 14574533 Disease Relevance 0.77 Pain Relevance 0.56
To measure the amount of Oil Red O in the stained samples, Oil Red O was eluted from the cells by adding 100% isopropanol and incubating for 1 hr, and then transferred to a 96-well plate and measured spectrophotometrically at 500 nm.


Positive_regulation (transferred) of Gene_expression (transferred) of Oil Red O
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0 Pain Relevance 0
These pathogenic effects can promote active changes in the infected human host, such as to increase cytokine production or to suppress MHC Class I (MHC I) presentation of viral proteins to the immune system.
Positive_regulation (increase) of Gene_expression (production) of cytokine in immune system associated with cytokine
5) Confidence 0.01 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 0.59 Pain Relevance 0.11
A single, large volume of blood collected has been shown to induce cytokine gene expression in the liver and lung of mice (Rajnik et al., 2002).
Positive_regulation (induce) of Gene_expression (expression) of cytokine gene in blood associated with cytokine
6) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.43 Pain Relevance 0.24
AKT promotes cell survival, and MAPKs and STATs are associated with induction of cytokine gene expression, from which we infer that these RA PB lymphocytes may actively participate in the inflammatory response.
Positive_regulation (induction) of Gene_expression (expression) of cytokine in lymphocytes associated with inflammatory response, rheumatoid arthritis and cytokine
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.02 Pain Relevance 0.49
In contrast, in the synovial-lining layer, the function of p38 might be completely different because it might exert its activity as a transcriptional inducer of proinflammatory cytokine synthesis [67,68].
Positive_regulation (inducer) of Gene_expression (synthesis) of cytokine associated with cytokine
8) Confidence 0.01 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 0.53 Pain Relevance 0.16
TNF has been shown to be involved in the stimulation of cytokine production, enhancing the expression of adhesion molecules, and in neutrophil activation.
Positive_regulation (stimulation) of Gene_expression (production) of cytokine in neutrophil associated with adhesions and cytokine
9) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 0.69 Pain Relevance 0.58
However, two potential sources of cytokine plasma levels have been suggested: first, the gradually accumulating normal tissue damage leads to an increased cytokine production within the irradiation field, which is launched into the blood circulation.
Positive_regulation (increased) of Gene_expression (production) of cytokine in blood associated with cytokine
10) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 0.90 Pain Relevance 0.33
However, two potential sources of cytokine plasma levels have been suggested: first, the gradually accumulating normal tissue damage leads to an increased cytokine production within the irradiation field, which is launched into the blood circulation.
Positive_regulation (leads) of Gene_expression (production) of cytokine in blood associated with cytokine
11) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 0.90 Pain Relevance 0.33
These new molecules have now helped to clarify the role of p38 MAPK in vitro and to define the mechanisms by which p38 MAPK controls for example LPS-induced cytokine expression in macrophages [19].
Positive_regulation (-) of Gene_expression (expression) of cytokine in macrophages associated with cytokine
12) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.05
These new molecules have now helped to clarify the role of p38 MAPK in vitro and to define the mechanisms by which p38 MAPK controls for example LPS-induced cytokine expression in macrophages [19].
Positive_regulation (induced) of Gene_expression (expression) of cytokine in macrophages associated with cytokine
13) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.05
Th1 cells promote cellular immunity and macrophage activation largely through the production of their signature proinflammatory cytokine IFN-?.
Positive_regulation (promote) of Gene_expression (production) of cytokine in Th1 cells associated with cytokine
14) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.59 Pain Relevance 0.23
The CB(2) antagonist, however, when administered alone augmented the production of cytokine mRNAs.
Positive_regulation (augmented) of Gene_expression (production) of cytokine associated with antagonist and cytokine
15) Confidence 0.00 Published 2000 Journal Glia Section Abstract Doc Link 10594923 Disease Relevance 0 Pain Relevance 0.73
Cytokine gene expression in sciatic nerve was significantly increased at day 7 for IL-1beta and IL-6 and at day 14 for TNF.
Positive_regulation (increased) of Gene_expression (expression) of Cytokine gene in sciatic nerve associated with sciatic nerve and cytokine
16) Confidence 0.00 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11358451 Disease Relevance 0.75 Pain Relevance 0.87
The data also demonstrated that cytokine mRNA inhibition correlates to the resolution of the inflammatory response in situ (n = 10), whereas the persistence/enhancement of cytokine message expression after treatment was associated with worsening of the skin condition, as seen in three erythema nodosum leprosum patients whose maintenance of local inflammation was accompanied by the appearance/persistence of interleukin-4 gene expression in situ subsequent to anti-inflammatory treatment.
Positive_regulation (persistence/enhancement) of Gene_expression (expression) of cytokine in skin associated with inflammatory response, inflammation, vasculitis and cytokine
17) Confidence 0.00 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 11121122 Disease Relevance 0.93 Pain Relevance 0.46
The progressive destruction of cartilage and bone in RA is a result of elevated pro-inflammatory cytokine gene expression, synovial neovascularization, proteinase-mediated dissolution of articular cartilage matrix and osteoclast-mediated subchondral bone resorption.
Positive_regulation (elevated) of Gene_expression (expression) of cytokine gene in osteoclast associated with inflammation, rheumatoid arthritis, hypercalcemia and cytokine
18) Confidence 0.00 Published 2007 Journal Clin. Chim. Acta Section Abstract Doc Link 16893535 Disease Relevance 1.27 Pain Relevance 0.55

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