INT85428

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.84
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100A8) extracellular region (S100A8) plasma membrane (S100A8)
cytoskeleton (S100A8) cytoplasm (S100A8)
Anatomy Link Frequency
platelet 1
bile 1
S100A8 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 30 100.00 Very High Very High Very High
Bile 53 99.50 Very High Very High Very High
peptic ulcer disease 6 99.22 Very High Very High Very High
abdominal pain 1 89.80 High High
nud 2 85.44 High High
ischemia 4 51.84 Quite High
medulla 1 49.28 Quite Low
sodium channel 6 47.04 Quite Low
agonist 5 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 30 100.00 Very High Very High Very High
Ulcers 19 99.64 Very High Very High Very High
Disease 21 99.22 Very High Very High Very High
Sprains And Strains 16 98.80 Very High Very High Very High
Infection 4 98.24 Very High Very High Very High
Gastritis 3 97.48 Very High Very High Very High
Gastroesophageal Reflux Disease 7 96.72 Very High Very High Very High
Prostate Cancer 55 95.92 Very High Very High Very High
Abdominal Pain 1 89.80 High High
Cancer 37 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of cagA status on the sensitivity of enzyme immunoassay in diagnosing Helicobacter pylori-infected children.
Regulation (Effect) of cagA associated with gastritis
1) Confidence 0.44 Published 1999 Journal Helicobacter Section Title Doc Link 10597391 Disease Relevance 0.37 Pain Relevance 0.09
The lack of influence of CagA positive Helicobacter pylori strains on gastro-oesophageal reflux disease.
Regulation (influence) of CagA associated with ulcers, disease and sprains and strains
2) Confidence 0.44 Published 2002 Journal Eur J Gastroenterol Hepatol Section Title Doc Link 12352217 Disease Relevance 0.94 Pain Relevance 0.09
The influence of CagA positive strains on oesophageal mucosa is discussed.


Regulation (influence) of CagA
3) Confidence 0.44 Published 2002 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 12352217 Disease Relevance 0 Pain Relevance 0
IBAT: ileal bile acid transporter; CFTR: cystic fibrosis transmembrane conductance regulator.
Regulation (regulator) of cystic fibrosis in bile associated with fibrosis, bile and cystic fibrosis
4) Confidence 0.44 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.32 Pain Relevance 0.19
Discrepancies among reports from different geographical regions worldwide on the association between the presence of cagA and peptic ulcer disease prompted this study on the predictive value of the cagA gene in Helicobacter pylori-associated gastroduodenal diseases in the Singapore population.
Regulation (value) of cagA associated with peptic ulcer disease, ulcers and disease
5) Confidence 0.26 Published 2000 Journal Microbios Section Abstract Doc Link 10885501 Disease Relevance 1.47 Pain Relevance 0.25
The importance of vacA, cagA, and iceA genotypes of Helicobacter pylori infection in peptic ulcer disease and gastroesophageal reflux disease.
Regulation (importance) of cagA associated with peptic ulcer disease, ulcers, gastroesophageal reflux disease, disease and infection
6) Confidence 0.26 Published 2001 Journal Am. J. Gastroenterol. Section Title Doc Link 11569682 Disease Relevance 0.49 Pain Relevance 0.10
There was no significant influence of CagA, as one of the H. pylori virulence factors, on GORD.
Neg (no) Regulation (influence) of CagA
7) Confidence 0.26 Published 2002 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 12352217 Disease Relevance 0.14 Pain Relevance 0
Our analysis has also identified a number of additional genes, such as KLK11,STC1 and S100A8 that are uniformly regulated in all metastatic patients.
Regulation (regulated) of S100A8
8) Confidence 0.21 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.06 Pain Relevance 0.03
All modified p8 peptides showed reduced platelet binding. p8-A534 (cf III-30c) lost all binding, while p8-A546 (cf III-30b) retained best binding.
Regulation (modified) of p8 in platelet
9) Confidence 0.11 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.05 Pain Relevance 0

General Comments

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