INT8545

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 27
Disease Relevance 15.96
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MUC16) extracellular region (MUC16) cell adhesion (MUC16)
plasma membrane (MUC16)
Anatomy Link Frequency
tear 1
blood 1
pleural fluid 1
MUC16 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 17 100.00 Very High Very High Very High
headache 1 99.84 Very High Very High Very High
Pain 6 99.24 Very High Very High Very High
Thoracotomy 1 97.32 Very High Very High Very High
endometriosis 105 95.56 Very High Very High Very High
adenocard 1 94.84 High High
Angina 1 94.24 High High
abdominal pain 3 92.32 High High
dexamethasone 1 91.12 High High
methotrexate 3 89.84 High High
Disease Link Frequency Relevance Heat
Dysmenorrhea 15 100.00 Very High Very High Very High
Ectopic Pregnancy 95 99.84 Very High Very High Very High
Headache 1 99.84 Very High Very High Very High
Endometriosis 133 99.78 Very High Very High Very High
Cancer 164 99.56 Very High Very High Very High
Ovarian Cancer 444 99.48 Very High Very High Very High
Nicotine Addiction 1 99.28 Very High Very High Very High
Syndrome 59 99.24 Very High Very High Very High
Pain 15 99.24 Very High Very High Very High
Uterine Fibroids 7 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum CA-125 levels were significantly decreased postoperatively.
Negative_regulation (decreased) of CA-125
1) Confidence 0.57 Published 1990 Journal J Reprod Med Section Abstract Doc Link 2141641 Disease Relevance 0.69 Pain Relevance 0.23
Adjuvant chemotherapy was required to alleviate frequent headaches and to decrease serum CA125 level and tumor size.
Negative_regulation (decrease) of CA125 associated with cancer and headache
2) Confidence 0.57 Published 2001 Journal Int. J. Clin. Oncol. Section Abstract Doc Link 11706787 Disease Relevance 0.88 Pain Relevance 0.35
During treatment by the combination chemotherapy with INH, RFP, EB, and PZA, serum CA 125 level was decreased.
Negative_regulation (decreased) of CA 125
3) Confidence 0.57 Published 2001 Journal Kekkaku Section Abstract Doc Link 11494528 Disease Relevance 1.08 Pain Relevance 0.17
Decreasing CA 125 reflected 3 of 5 imaged regressions.
Negative_regulation (Decreasing) of CA 125
4) Confidence 0.57 Published 2001 Journal J. Urol. Section Body Doc Link 11371879 Disease Relevance 0.06 Pain Relevance 0
Although we did not stain the ocular surface of the subjects at the time of their visit for tear and cell collection in this study, our results suggest that staining scores, at least in SS patients, would not correlate with a reduction in membrane MUC16, as we found no differences in membrane bound MUC16 expression in any of our subject groups.
Negative_regulation (reduction) of MUC16 in tear associated with syndrome
5) Confidence 0.51 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.60 Pain Relevance 0
While we used the cut-off of 35 U/ml to divide our patient population into 4 groups based on their CA125 levels at baseline and 3 months, the other 2 studies used percentage change methodology to quantify the increase as well as decrease in CA125 levels over time.
Negative_regulation (decrease) of CA125
6) Confidence 0.49 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.37 Pain Relevance 0
The CA 125 level (8400 U/ml) rapidly declined to 150 U/ml by this CAP therapy.
Negative_regulation (declined) of CA 125
7) Confidence 0.42 Published 2004 Journal Curr. Med. Chem. Section Abstract Doc Link 14965223 Disease Relevance 0.74 Pain Relevance 0
At the laparoscopic examination, it was determined to be a ruptured endometrioma and serum CA 125 concentrations rapidly decreased after surgery.
Negative_regulation (decreased) of CA 125 associated with endometriosis
8) Confidence 0.42 Published 2003 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 14584668 Disease Relevance 0.44 Pain Relevance 0.09
The serum and pleural fluid levels of carcinoembryonic antigens, CA-125 and CA19-9 were invariably elevated, then decreased to normal range after the surgical resection.
Negative_regulation (decreased) of CA-125 in pleural fluid
9) Confidence 0.42 Published 2001 Journal Pediatr Hematol Oncol Section Abstract Doc Link 11293292 Disease Relevance 0.62 Pain Relevance 0.14
The CA 125 level in patients with adenomyosis gradually decreased postoperatively and in all was below 35U/ml up to one month postoperatively.
Negative_regulation (decreased) of CA 125 associated with dismenorea
10) Confidence 0.42 Published 1985 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 3857281 Disease Relevance 1.49 Pain Relevance 0.74
In this cohort, patients with an improved (decreased) serum CA125 levels at 3 months (stratum 2) had a significantly better survival than those with deteriorated (increased) serum CA125 levels at 3 months (stratum 3).
Negative_regulation (decreased) of CA125
11) Confidence 0.42 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.07 Pain Relevance 0
The study concluded that the reduction in the serum CA125 concentration over the initial two cycles of platinum-based chemotherapy is a powerful independent predictor of survival for patients with suboptimal stage III or IV ovarian cancer [35].
Negative_regulation (reduction) of CA125 associated with ovarian cancer
12) Confidence 0.42 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.53 Pain Relevance 0
The findings of our study, specifically the positive impact of CA125 reduction on overall survival, compare well with those of the above mentioned studies.
Negative_regulation (reduction) of CA125
13) Confidence 0.42 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.21 Pain Relevance 0
Some authors reported that serum CA 125 levels were significantly lower in EP as compared to intrauterine pregnancies.
Negative_regulation (lower) of CA 125 associated with ectopic pregnancy
14) Confidence 0.41 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.94 Pain Relevance 0
Prognostic value of CA 125 in advanced ovarian cancer.
Negative_regulation (value) of CA 125 associated with ovarian cancer
15) Confidence 0.41 Published 1992 Journal Gynecol. Oncol. Section Title Doc Link 1541430 Disease Relevance 0.32 Pain Relevance 0.05
Elevated levels of CA 125 and tissue polypeptide antigen were found in the cancer patients, predominantly within the first 1-3 weeks after surgery.
Negative_regulation (levels) of CA 125 associated with cancer
16) Confidence 0.41 Published 1992 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 1374604 Disease Relevance 0.84 Pain Relevance 0.09
There is no adequate data in the medical literature defining serum CA-125 levels after laparotomy.
Negative_regulation (defining) of CA-125
17) Confidence 0.41 Published 2004 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 15597853 Disease Relevance 0.22 Pain Relevance 0.07
[Clinical usefulness of the combination assay of CA 125, SLX, and CA 72-4 in patients with ovarian cancer].
Negative_regulation (usefulness) of CA 125 associated with ovarian cancer
18) Confidence 0.41 Published 1989 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Title Doc Link 2574209 Disease Relevance 1.06 Pain Relevance 0.08
We propose that measurement of CA 125 in the menstrual blood may be able to help distinguishing adenomyosis from myoma uteri and may also help in assessing clinical endometriosis.
Negative_regulation (measurement) of CA 125 in blood associated with endometriosis, dismenorea and myoma
19) Confidence 0.41 Published 1988 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 3169631 Disease Relevance 0.57 Pain Relevance 0.33
We therefore intend to proceed with evaluation of MUC16, WFDC2, MSLN and MMP7, all of which have sensitivity >30% at 98% specificity in detection of clinically apparent serous cancers, beginning with analysis of serum specimens collected months to years prior to diagnosis of serous ovarian cancers.
Negative_regulation (evaluation) of MUC16 associated with cancer and ovarian cancer
20) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 1.01 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox