INT8546

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 99
Total Number 102
Disease Relevance 74.98
Pain Relevance 11.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MUC16) extracellular region (MUC16) cell adhesion (MUC16)
plasma membrane (MUC16)
Anatomy Link Frequency
uterine 5
plasma 4
tear 3
peritoneum 2
eye 2
MUC16 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 121 99.82 Very High Very High Very High
abdominal pain 26 99.70 Very High Very High Very High
Dismenorea 30 99.28 Very High Very High Very High
pain pelvic 25 99.00 Very High Very High Very High
Chronic pancreatitis 6 98.80 Very High Very High Very High
anesthesia 38 98.52 Very High Very High Very High
Inflammation 41 97.48 Very High Very High Very High
Thoracotomy 1 97.32 Very High Very High Very High
backache 5 96.80 Very High Very High Very High
Pain 26 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ovarian Cancer 746 100.00 Very High Very High Very High
Cancer 680 100.00 Very High Very High Very High
Pleural Effusion 25 99.96 Very High Very High Very High
Syndrome 558 99.90 Very High Very High Very High
Recurrence 94 99.90 Very High Very High Very High
Uterine Fibroids 60 99.90 Very High Very High Very High
Pressure And Volume Under Development 36 99.90 Very High Very High Very High
Anaemia 25 99.90 Very High Very High Very High
Reprotox - General 3 37 99.84 Very High Very High Very High
Endometriosis 92 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that Sjogren’s subjects express significantly elevated concentrations of both soluble MUC16 and MUC16 mRNA compared to both KCS and NDE groups.
Positive_regulation (elevated) of MUC16 associated with sjoegrens syndrome and eye disease
1) Confidence 0.69 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.85 Pain Relevance 0
We found that Sjogren’s subjects express significantly elevated concentrations of both soluble MUC16 and MUC16 mRNA compared to both KCS and NDE groups.
Positive_regulation (elevated) of MUC16 associated with sjoegrens syndrome and eye disease
2) Confidence 0.69 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.85 Pain Relevance 0
Nine women with elevated CA-125 levels before treatment, were found without recurrence of endometriosis and had normal CA-125 levels one year after therapy.
Positive_regulation (elevated) of CA-125
3) Confidence 0.67 Published 1998 Journal Acta Obstet Gynecol Scand Section Body Doc Link 9688246 Disease Relevance 0 Pain Relevance 0
Fifteen patients had elevated CA-125 levels before and one year after therapy, and were confirmed with recurrence of endometriosis by laparoscopy.
Positive_regulation (elevated) of CA-125
4) Confidence 0.67 Published 1998 Journal Acta Obstet Gynecol Scand Section Body Doc Link 9688246 Disease Relevance 0.10 Pain Relevance 0
The serum and pleural fluid levels of carcinoembryonic antigens, CA-125 and CA19-9 were invariably elevated, then decreased to normal range after the surgical resection.
Positive_regulation (elevated) of CA-125 in pleural fluid
5) Confidence 0.67 Published 2001 Journal Pediatr Hematol Oncol Section Abstract Doc Link 11293292 Disease Relevance 0.62 Pain Relevance 0.14
Laboratory results showed anemia and elevated CA 125 levels.
Positive_regulation (elevated) of CA 125 associated with anaemia
6) Confidence 0.67 Published 2010 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 20173496 Disease Relevance 0.85 Pain Relevance 0.10
The authors report on a case of Meigs' syndrome in a patient admitted with vomiting, abdominal pain, peritoneal and right pleural effusion, increased serum levels of CA 125.
Positive_regulation (increased) of CA 125 associated with pleural effusion, abdominal pain, syndrome and vomiting
7) Confidence 0.67 Published 1996 Journal G Chir Section Abstract Doc Link 8754555 Disease Relevance 0.47 Pain Relevance 0.10
In women with cystic ovarian endometriosis, plasma CA 125 concentrations are markedly elevated.
Positive_regulation (elevated) of CA 125 in plasma associated with endometriosis
8) Confidence 0.67 Published 1993 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 8365504 Disease Relevance 0.88 Pain Relevance 0.33
An elevated serum squamous cell carcinoma antigen was found in the two cases of advanced stage and one of them also had an elevated serum CA-125 level.
Positive_regulation (elevated) of CA-125 associated with skin cancer
9) Confidence 0.67 Published 1993 Journal Changgeng Yi Xue Za Zhi Section Abstract Doc Link 8221296 Disease Relevance 0.99 Pain Relevance 0.08
CA-125 level was also significantly increased in women with peritoneal endometriosis (70.7 +/- 47.3 vs. 33.5 +/- 25.6 U/ml for those with ovarian endometriosis), and in these patients the post-operative CA-125 level was significantly related to the clinical evolution of the disease, being higher in patients whose disease recurred compared to those with negative follow-up, irrespective of the adhesion score.
Positive_regulation (increased) of CA-125 associated with endometriosis, disease and adhesions
10) Confidence 0.67 Published 1994 Journal Gynecol. Endocrinol. Section Abstract Doc Link 8059614 Disease Relevance 1.56 Pain Relevance 0.36
Serum CA 125 concentrations are elevated in some women with endometriosis; however, the low sensitivity and specificity of the assay have made it impractical to use it as a diagnostic test for endometriosis.
Positive_regulation (elevated) of CA 125 associated with endometriosis
11) Confidence 0.67 Published 1995 Journal Hum. Reprod. Section Abstract Doc Link 7650145 Disease Relevance 0.57 Pain Relevance 0.28
RESULTS: Of the 68 patients 48 (71%) had increased CA 125.
Positive_regulation (increased) of CA 125
12) Confidence 0.67 Published 2001 Journal J. Urol. Section Body Doc Link 11371879 Disease Relevance 0.08 Pain Relevance 0
PURPOSE: The discovery of increased CA 125 in a patient with metastatic bladder carcinoma prompted a prospective study to screen those referred for consideration of adjuvant or palliative chemotherapy of advanced urothelial malignancy for high serum CA 125.
Positive_regulation (increased) of CA 125 in bladder associated with malignant neoplastic disease, bladder cancer and palliative
13) Confidence 0.67 Published 2001 Journal J. Urol. Section Abstract Doc Link 11371879 Disease Relevance 0.50 Pain Relevance 0.09
We present the case of a patient with advanced endometriosis who presented with chronic pelvic pain, bilateral unruptured ovarian endometrioma, massive peritoneal implants and extremely elevated CA 125, and also elevated CA 15-3 levels.
Positive_regulation (elevated) of CA 125 associated with endometriosis and pain pelvic
14) Confidence 0.67 Published 2008 Journal Clin Exp Obstet Gynecol Section Abstract Doc Link 18754302 Disease Relevance 0.63 Pain Relevance 0.22
A frozen section specimen suggested a papillary adenocarcinoma, which was confirmed to be metastatic primary papillary serous carcinoma of the peritoneum by immunohistochemistry, an elevated serum cancer antigen (CA-125) level, and abdominal CT findings.
Spec (findings) Positive_regulation (elevated) of CA-125 in peritoneum associated with papillary adenocarcinoma, cancer and carcinoma
15) Confidence 0.67 Published 2008 Journal Surg. Today Section Abstract Doc Link 18668320 Disease Relevance 0.88 Pain Relevance 0.08
We present here a unique case of non-Hodgkin's lymphoma involving the ovaries presenting as advanced ovarian cancer with a pelvic mass, pleural effusion, and marked elevation of CA-125.
Positive_regulation (elevation) of CA-125 in ovaries associated with pleural effusion, lymphatic system cancer and ovarian cancer
16) Confidence 0.67 Published 2005 Journal Int. J. Gynecol. Cancer Section Abstract Doc Link 15882185 Disease Relevance 1.12 Pain Relevance 0.09
Biological tumor markers are nonspecific: an increased serum level of carcinoembryonic antigen is relevant when associated with an increased level of CA 19-9 or CA-125.
Positive_regulation (increased) of CA-125 associated with cancer
17) Confidence 0.67 Published 2004 Journal Rom J Intern Med Section Abstract Doc Link 15529594 Disease Relevance 0.99 Pain Relevance 0.09
Although 7 cycles of CAP was added, ascites and elevation of CA 125 (5100 U/ml) were observed.
Positive_regulation (elevation) of CA 125 associated with pressure and volume under development
18) Confidence 0.67 Published 2004 Journal Curr. Med. Chem. Section Abstract Doc Link 14965223 Disease Relevance 0.92 Pain Relevance 0.10
Her serum level of CA-125 was only slightly elevated.
Positive_regulation (elevated) of CA-125
19) Confidence 0.67 Published 2003 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 14641686 Disease Relevance 0.85 Pain Relevance 0.09
In one patient cholangitis due to biliary obstruction induced a significant transient increase of CA 19-9, in another patient HUS, probably as a severe complication after Mitomycin-C + Gemcitabine therapy resulted in a significant increase of serum CA 125.
Positive_regulation (increase) of CA 125 associated with cholangitis and hemolytic uremic syndrome
20) Confidence 0.67 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12820311 Disease Relevance 0.67 Pain Relevance 0.12

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