INT85462

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 2.91
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
podocyte 2
nerve 1
naevus 1
KTWS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 98.72 Very High Very High Very High
Lasting pain 3 98.08 Very High Very High Very High
Nerve growth factor 3 95.96 Very High Very High Very High
Pain 2 93.08 High High
hyperexcitability 3 75.00 Quite High
Action potential 1 54.56 Quite High
Spontaneous pain 1 31.92 Quite Low
withdrawal 22 5.00 Very Low Very Low Very Low
member 8 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 7 99.92 Very High Very High Very High
Neuropathic Pain 1 99.32 Very High Very High Very High
INFLAMMATION 1 98.72 Very High Very High Very High
Polydactyly 1 98.20 Very High Very High Very High
Pain 5 98.08 Very High Very High Very High
Symphalangism 1 97.68 Very High Very High Very High
Macrocephaly 1 96.52 Very High Very High Very High
Blue Nevus 1 95.96 Very High Very High Very High
Thrombosis Related Under Development 1 95.64 Very High Very High Very High
Renal Disease 66 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KTS can be associated with other developmental anomalies such as: polydactyly, syndactyly, oligodactyly [2] macrocephaly, blue nevus, epidermal naevus, venous malformations.
KTS Binding (associated) of in naevus associated with macrocephaly, symphalangism, polydactyly and blue nevus
1) Confidence 0.31 Published 1999 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10599395 Disease Relevance 1.45 Pain Relevance 0.09
The unexpected finding that the identified transcripts were not associated with WT1(+KTS) prompted us to attempt to uncover a plausible explanation to account for the identification of this subset of mRNAs encoding a remarkable functionally interrelated set of proteins.
KTS Binding (associated) of
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
We originally sought to identify mRNAs associated with WT1(+KTS) through an RNA immunoprecipitation and microarray approach, hypothesizing that the proteins encoded by these mRNAs might be important for podocyte morphology and function.
KTS Binding (associated) of in podocyte
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2714980 Disease Relevance 0.43 Pain Relevance 0
These results were highly reproducible and thus the enrichment of Myh10 in the pulldowns using empty vector control extracts clearly indicated that the enrichment of this mRNA did not require an association with WT1(+KTS).
KTS Neg (not) Binding (association) of
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
Although the co-purified mRNAs were not enriched due to an association with WT1(+KTS), the significant examples of their common functions in the actin cytoskeleton raised the question as to how or why they were specifically enriched in the pull down assays.
KTS Binding (association) of
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
Thus, despite the identification of a previously described WT1(+KTS) target mRNA in the results and the remarkable physiologically relevant functions of the encoded proteins, these results established that their identification was not due to WT1(+KTS) binding as envisioned by the experimental design.


KTS Binding (binding) of
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
An underlying hypothesis was that the proteins encoded by mRNAs bound by WT1(+KTS) might define a “post-transcriptional operon” that is important for maintenance of podocyte morphology and function [26].
KTS Binding (bound) of in podocyte
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.13 Pain Relevance 0
This observation was consistent with the hypothesis that the mRNAs that we identified were bound by and associated specifically with WT1(+KTS).
KTS Binding (associated) of
8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.25 Pain Relevance 0
Further validation experiments using qRT-PCR were carried out to more definitively determine whether the enrichment of these mRNAs was specifically due to association with WT1(+KTS).
KTS Binding (association) of
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.11 Pain Relevance 0
However, we were surprised to find that in subsequent validations, we detemined that the enrichment these mRNAs was clearly not due to association with WT1(+KTS).
KTS Binding (association) of
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0.18 Pain Relevance 0
However, these mRNAs were subsequently, and unexpectedly, shown not to be bound by WT1(+KTS).
KTS Binding (bound) of
11) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
However, while our findings did not address the original hypothesis that WT1(+KTS) directly binds mRNAs in vivo, we nonetheless identified transcripts that encode a subset of interrelated, physiologically relevant proteins that we propose will provide further insights into actin cytoskeletal organization.


KTS Binding (binds) of
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
We studied the interaction of human keratinocytes (hKTs) and regenerating afferent nerve fibers by transplanting hKTs into a ligated and transected peripheral nerve.
hKTs Binding (interaction) of in nerve
13) Confidence 0.00 Published 2010 Journal Pain Section Abstract Doc Link 19932564 Disease Relevance 0.37 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox