INT85464

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.62
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cartpt) extracellular region (Cartpt)
Anatomy Link Frequency
shell 1
medial 1
striatum 1
lever 1
PVT 1
Cartpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 10 99.88 Very High Very High Very High
tetrodotoxin 48 99.84 Very High Very High Very High
cocaine 197 99.72 Very High Very High Very High
Thalamus 150 99.56 Very High Very High Very High
Nucleus accumbens 83 99.04 Very High Very High Very High
amygdala 22 97.60 Very High Very High Very High
Neurotransmitter 4 86.32 High High
Neuropeptide 7 85.64 High High
alcohol 17 57.00 Quite High
Morphine 4 41.76 Quite Low
Disease Link Frequency Relevance Heat
Aids-related Complex 11 96.84 Very High Very High Very High
Recurrence 22 89.84 High High
Osteogenic Sarcomas 2 84.48 Quite High
Stress 6 80.72 Quite High
Tremor 6 34.00 Quite Low
Cocaine Dependence 10 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cocaine- and amphetamine-regulated transcript (CART) peptides attracted much attention after the discovery that the level of CART mRNA is increased in rat striatum after acute administration of cocaine and amphetamine.
Positive_regulation (increased) of CART mRNA in striatum associated with cocaine
1) Confidence 0.70 Published 2006 Journal Peptides Section Abstract Doc Link 16730858 Disease Relevance 0.08 Pain Relevance 0.10
In the medial accumbens shell CART mRNA was elevated after cocaine, but only in the non-treated females.
Positive_regulation (elevated) of CART in medial associated with cocaine
2) Confidence 0.61 Published 1999 Journal Neuroreport Section Abstract Doc Link 10599860 Disease Relevance 0 Pain Relevance 0.22
A gender difference was noted in the accumbens shell during basal conditions; male rats expressed higher levels of CART mRNA than both female groups.
Positive_regulation (levels) of CART in shell
3) Confidence 0.50 Published 1999 Journal Neuroreport Section Abstract Doc Link 10599860 Disease Relevance 0 Pain Relevance 0.21
This effect was specific to the PVT region, as misplaced injections of both TTX and CART resulted in responding that was identical to controls.


Positive_regulation (injections) of CART in PVT associated with thalamus
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2944892 Disease Relevance 0.06 Pain Relevance 0.82
It is noteworthy that PVT-directed treatment did not alter responding on the inactive lever, suggesting that the effects we observed were specific to drug-seeking rather than a generalized reduction in arousal or locomotor activity as a result of CART or TTX infusion.
Positive_regulation (result) of CART in lever associated with tetrodotoxin, eae and thalamus
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944892 Disease Relevance 0.21 Pain Relevance 0.60
Category 1 changes in CART, NPY (both increased at 1-day) and Egr1 (decreased at 1-day) in the mPFC were also confirmed by qPCR (Table 2).


Positive_regulation (increased) of CART
6) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.26 Pain Relevance 0.22

General Comments

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