INT8547

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 116
Total Number 119
Disease Relevance 75.97
Pain Relevance 12.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MUC16) extracellular region (MUC16) cell adhesion (MUC16)
plasma membrane (MUC16)
Anatomy Link Frequency
tear 7
epithelial cells 4
uterine 3
eye 3
surface epithelium 2
MUC16 (Homo sapiens)
Pain Link Frequency Relevance Heat
pain pelvic 27 100.00 Very High Very High Very High
Dismenorea 80 99.98 Very High Very High Very High
endometriosis 200 99.90 Very High Very High Very High
abdominal pain 38 98.86 Very High Very High Very High
Thoracotomy 1 98.80 Very High Very High Very High
Inflammatory mediators 4 98.64 Very High Very High Very High
nud 5 97.48 Very High Very High Very High
Inflammation 67 97.36 Very High Very High Very High
palliative 2 96.44 Very High Very High Very High
Angina 3 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ovarian Cancer 1369 100.00 Very High Very High Very High
Endometriosis 188 100.00 Very High Very High Very High
Reprotox - General 3 42 100.00 Very High Very High Very High
Skin Cancer 7 100.00 Very High Very High Very High
Dysmenorrhea 65 99.98 Very High Very High Very High
Endometroid Carcinoma 11 99.98 Very High Very High Very High
Ectopic Pregnancy 570 99.80 Very High Very High Very High
Disease 835 99.76 Very High Very High Very High
Cancer 786 99.72 Very High Very High Very High
Syndrome 1156 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no amplification of the CA125 expression in heterotopic EC membranes.
Gene_expression (expression) of CA125
1) Confidence 0.78 Published 1992 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 1607752 Disease Relevance 0.09 Pain Relevance 0.15
[Qualitative assessment and characterization of CA125 antigen produced from human endometrial epithelial cells].
Gene_expression (produced) of CA125 in epithelial cells
2) Confidence 0.78 Published 1992 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Title Doc Link 1607752 Disease Relevance 0.07 Pain Relevance 0.07
The CA125 expression was mainly observed in the G0/G1-phase in the cell cycle.
Gene_expression (expression) of CA125
3) Confidence 0.78 Published 1992 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 1607752 Disease Relevance 0.08 Pain Relevance 0.08
We have established an in vitro system in which epithelial cells (EC) and stromal cells (SC) from the human endometrium are placed in culture to examine the production of CA125.
Spec (examine) Gene_expression (production) of CA125 in epithelial cells
4) Confidence 0.78 Published 1992 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 1607752 Disease Relevance 0 Pain Relevance 0
We propose that conjunctival cells in Sjogren’s syndrome increase their production of MUC16 as a compensatory mechanism to maintain their healthy phenotype.



Gene_expression (production) of MUC16 associated with syndrome
5) Confidence 0.78 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.78 Pain Relevance 0
Although we did not stain the ocular surface of the subjects at the time of their visit for tear and cell collection in this study, our results suggest that staining scores, at least in SS patients, would not correlate with a reduction in membrane MUC16, as we found no differences in membrane bound MUC16 expression in any of our subject groups.
Gene_expression (expression) of MUC16 in tear associated with syndrome
6) Confidence 0.78 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.56 Pain Relevance 0
Lastly, no correlation between tear flow and MUC16 expression was found in any group.
Gene_expression (expression) of MUC16 in tear
7) Confidence 0.78 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.99 Pain Relevance 0
No differences were found in MUC16 expression between the KCS and NDE subjects.
Gene_expression (expression) of MUC16 associated with sjoegrens syndrome and eye disease
8) Confidence 0.78 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.85 Pain Relevance 0
No correlation was found between tear flow and MUC16 expression.
Gene_expression (expression) of MUC16 in tear
9) Confidence 0.78 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.80 Pain Relevance 0
Since our results demonstrated no correlation between tear flow and MUC16 concentration, we believe that it is the unique nature of autoimmune related dry eye that influences the stimulus for MUC16 expression.
Gene_expression (expression) of MUC16 in tear associated with dry eye
10) Confidence 0.78 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.76 Pain Relevance 0
Expression of CA 125 in adenomyosis.
Gene_expression (Expression) of CA 125 associated with dismenorea
11) Confidence 0.75 Published 1987 Journal Gynecol. Obstet. Invest. Section Title Doc Link 3472995 Disease Relevance 0.29 Pain Relevance 0.38
[Fundamental and clinical study on source of CA 125 antigen in cul-de-sac fluid and translation into systemic circulation].
Gene_expression (source) of CA 125
12) Confidence 0.75 Published 1989 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Title Doc Link 2746065 Disease Relevance 0.64 Pain Relevance 0.19
Although CA 125 is a useful marker of ovarian cancer and, reportedly, is expressed by a few other tumors, to our knowledge no association with transitional cell malignancy of the urothelium has been previously described.
Gene_expression (expressed) of CA 125 associated with malignant neoplastic disease, cancer and ovarian cancer
13) Confidence 0.75 Published 2001 Journal J. Urol. Section Abstract Doc Link 11371879 Disease Relevance 0.64 Pain Relevance 0.10
Serum levels of squamous cell carcinoma antigen, carcinoembryonic antigen, CA 125, tissue polypeptide antigen, CRP, alpha 1-antitrypsin and haptoglobin were determined peri- and postoperatively in patients undergoing surgery for benign gynecological disease (n = 18) and postoperatively in women operated for cervical carcinoma (n = 23).
Spec (determined) Gene_expression (levels) of CA 125 associated with gynecological disease, skin cancer and reprotox - general 1
14) Confidence 0.75 Published 1992 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 1374604 Disease Relevance 0.62 Pain Relevance 0.07
CA 125 is expressed by eutopic and ectopic endometrium.
Gene_expression (expressed) of CA 125 in endometrium
15) Confidence 0.75 Published 1993 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 8365504 Disease Relevance 0.50 Pain Relevance 0.16
The tissues suspected of producing CA 125 in normal women include the endometrium, the ovary and the peritoneum.
Gene_expression (producing) of CA 125 in peritoneum
16) Confidence 0.75 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1532397 Disease Relevance 0.53 Pain Relevance 0.20
In summary, we quantified the expression of ocular surface MUC16 in Sjogren’s subjects and compared them with non-Sjogren’s dry-eyed subjects and non-dry eyed controls.
Gene_expression (expression) of MUC16
17) Confidence 0.68 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.97 Pain Relevance 0
[Qualitative assessment and characterization of CA125 antigen produced from human endometrial epithelial cells].
Gene_expression (assessment) of CA125 in epithelial cells
18) Confidence 0.68 Published 1992 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Title Doc Link 1607752 Disease Relevance 0.07 Pain Relevance 0.07
We found that Sjogren’s subjects express significantly elevated concentrations of both soluble MUC16 and MUC16 mRNA compared to both KCS and NDE groups.
Gene_expression (express) of MUC16 associated with sjoegrens syndrome and eye disease
19) Confidence 0.67 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.86 Pain Relevance 0
Monoclonal mouse anti-human MUC16 antibody (OC125) was purchased from DAKO (Glostrup, Denmark) and goat anti-mouse IgG-HRP from Santa Cruz Biotechnology Inc.
Gene_expression (antibody) of MUC16
20) Confidence 0.67 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.40 Pain Relevance 0.07

General Comments

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