INT8548

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Context Info
Confidence 0.77
First Reported 1981
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 86
Total Number 88
Disease Relevance 47.62
Pain Relevance 11.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HP)
Anatomy Link Frequency
blood 7
liver 2
CSF 2
hepatocytes 1
erythrocytes 1
HP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 217 100.00 Very High Very High Very High
antagonist 55 100.00 Very High Very High Very High
Opioid 32 100.00 Very High Very High Very High
Dopamine 96 99.84 Very High Very High Very High
spinal inflammation 106 99.42 Very High Very High Very High
Inflammation 229 99.36 Very High Very High Very High
Angina 22 99.28 Very High Very High Very High
depression 106 99.10 Very High Very High Very High
rheumatoid arthritis 98 96.96 Very High Very High Very High
agonist 35 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 1302 100.00 Very High Very High Very High
Hypertension 886 100.00 Very High Very High Very High
Cancer 274 100.00 Very High Very High Very High
Infection 44 100.00 Very High Very High Very High
Alzheimer's Dementia 21 100.00 Very High Very High Very High
Skin Cancer 6 100.00 Very High Very High Very High
Atrophic Gastritis 7 99.88 Very High Very High Very High
Pancreatic Cancer 50 99.70 Very High Very High Very High
Chronic Renal Failure 26 99.66 Very High Very High Very High
Hemolysis 143 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coculturing of a human hepatoma cell line, Hep3B, with PC cells-induced production of fucosylated haptoglobin, suggesting that PC produces a factor that induces the production of fucosylated haptoglobin.
Gene_expression (production) of haptoglobin associated with pancreatic cancer and hepatocellular cancer
1) Confidence 0.77 Published 2008 Journal Proteomics Section Abstract Doc Link 18646007 Disease Relevance 1.67 Pain Relevance 0.14
While the appearance of fucosylated haptoglobin has been reported in other diseases such as hepatocellular carcinoma, liver cirrhosis, gastric cancer, and colorectal cancer, the incidence was significantly higher in the case of PC.
Gene_expression (appearance) of haptoglobin in liver associated with cirrhosis, pancreatic cancer, colon cancer, hepatocellular cancer, disease and stomach cancer
2) Confidence 0.77 Published 2008 Journal Proteomics Section Abstract Doc Link 18646007 Disease Relevance 1.43 Pain Relevance 0.05
Coculturing of a human hepatoma cell line, Hep3B, with PC cells-induced production of fucosylated haptoglobin, suggesting that PC produces a factor that induces the production of fucosylated haptoglobin.
Gene_expression (production) of haptoglobin associated with pancreatic cancer and hepatocellular cancer
3) Confidence 0.77 Published 2008 Journal Proteomics Section Abstract Doc Link 18646007 Disease Relevance 1.59 Pain Relevance 0.14
On clinical investigation of 100 cases of colorectal cancer, cases in which it was located near the liver showed a higher positive rate of fucosylated haptoglobin, suggesting that the location of the cancer might also be an important factor for fucosylated haptoglobin if cancer tissues produce such inducible factors.
Gene_expression (produce) of haptoglobin in liver associated with cancer and colon cancer
4) Confidence 0.67 Published 2008 Journal Proteomics Section Abstract Doc Link 18646007 Disease Relevance 1.35 Pain Relevance 0.12
Similarly HR, blood pressure (BP), and the HR x BP product levels during the ischemic stress condition and the HR discrimination performance do not show group differences.
Gene_expression (product) of BP in blood associated with stress
5) Confidence 0.61 Published 1982 Journal Biofeedback Self Regul Section Abstract Doc Link 7138951 Disease Relevance 0.26 Pain Relevance 0.08
Laboratory evaluation showed hemolytic anemia with fragmentation, thrombocytopenia, elevated lactic dehydrogenase level, low haptoglobin level, low complement C3 level, and elevated antistreptolysin-O titer.
Gene_expression (level) of haptoglobin associated with hemolytic anemia and thrombocytopenia
6) Confidence 0.52 Published 2005 Journal Am. J. Kidney Dis. Section Abstract Doc Link 16183409 Disease Relevance 1.55 Pain Relevance 0.09
In both soluble and membrane fractions, the alpha 2-adrenoceptor binding being masked with (-)norepinephrine, [3H]clonidine bound to a low affinity site which was insensitive to (-)norepinephrine and which exhibited the same selectivity for various drugs as the [3H]idazoxan binding site. alpha 2-adrenoceptor binding was present in the membrane and the soluble fractions although it was difficult to detect in the soluble fraction because of inhibition of [3H]rauwolscine binding by the CHAPS detergent.
Gene_expression (present) of binding associated with clonidine
7) Confidence 0.50 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7994199 Disease Relevance 0 Pain Relevance 0.32
Hemoglobin was 7.9 g/dL, lactate dehydrogenase was 2,295 IU/L, haptoglobin was less than 10 mg/dL, reticulocyte count was elevated, and Coombs' test was negative.
Neg (negative) Gene_expression (negative) of haptoglobin in reticulocyte
8) Confidence 0.47 Published 2008 Journal Ann. Thorac. Surg. Section Abstract Doc Link 18640351 Disease Relevance 0.70 Pain Relevance 0.18
Increased expression of haptoglobin precursor were also observed in sera of sporadic AS patients.
Gene_expression (expression) of haptoglobin precursor associated with spinal inflammation
9) Confidence 0.38 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17434140 Disease Relevance 0.91 Pain Relevance 0.95
COX-2 synthesizes prostaglandin E2 (PGE2) which stimulates bcl-2 and inhibits apoptosis, and induces interleukin-6 (IL-6) which enhances haptoglobin synthesis.
Gene_expression (synthesis) of haptoglobin in PGE2 associated with apoptosis
10) Confidence 0.29 Published 2000 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 10678579 Disease Relevance 1.79 Pain Relevance 0.41
Blood samples were taken from calves with respiratory disease the first day of examination for determination of the serum concentration of haptoglobin, fibrinogen, alpha-2- and gamma-globulins, and albumin.
Gene_expression (concentration) of haptoglobin in respiratory associated with respiratory disease
11) Confidence 0.28 Published 2004 Journal Res. Vet. Sci. Section Abstract Doc Link 15120951 Disease Relevance 0.40 Pain Relevance 0.11
-1-antichymotrypsin; the metal transport and antioxidant proteins ceruloplasmin (ferroxidase II), haptoglobin and orosomucoid 2 (ORM2; ?
Gene_expression (proteins) of haptoglobin
12) Confidence 0.27 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.64 Pain Relevance 0.08
Changes in serum expression of haptoglobin correlated with the change of CA-125 levels before and after chemotherapy [25].
Gene_expression (expression) of haptoglobin
13) Confidence 0.24 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.26 Pain Relevance 0
Serum levels of squamous cell carcinoma antigen, carcinoembryonic antigen, CA 125, tissue polypeptide antigen, CRP, alpha 1-antitrypsin and haptoglobin were determined peri- and postoperatively in patients undergoing surgery for benign gynecological disease (n = 18) and postoperatively in women operated for cervical carcinoma (n = 23).
Spec (determined) Gene_expression (levels) of haptoglobin associated with gynecological disease, skin cancer and reprotox - general 1
14) Confidence 0.22 Published 1992 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 1374604 Disease Relevance 0.64 Pain Relevance 0.08
Haptoglobin was undetectable in hyper-hemolysis patients compared to 5 subjects with measurable levels among low LDH subjects (mean 70.6 mg/dL, n?
Gene_expression (undetectable) of Haptoglobin associated with hemolysis
15) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 0.74 Pain Relevance 0
These were 5 of only 6 detectable haptoglobin levels within the NIH population where this was measured (n?
Gene_expression (levels) of haptoglobin
16) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 0.82 Pain Relevance 0.07
On days 1, 7 and 21 the retrobulbar venous plexus of all animals was punctured, 0.5 ml blood was extracted and serological levels of troponinT, NT-proBNP and haptoglobin were determined.
Gene_expression (levels) of haptoglobin in blood
17) Confidence 0.21 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2936396 Disease Relevance 0.29 Pain Relevance 0.04
Pathologcially raised levels of haptoglobin in control group can be explained by the unspecific inflammation caused by Complete Freud's Adjuvance injected in control animals.


Gene_expression (levels) of haptoglobin associated with inflammation
18) Confidence 0.21 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2936396 Disease Relevance 0.81 Pain Relevance 0.14
Animals in experimental group had significantly higher serological levels of haptoglobin and troponinT on day 21 compared to animals of control group (see table 2: Mann-Whitney test).
Gene_expression (levels) of haptoglobin
19) Confidence 0.21 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2936396 Disease Relevance 0 Pain Relevance 0
For example, IL-6 initiates the acute-phase response inducing the hepatic synthesis of acute phase proteins including C-reactive protein (CRP), serum amyloid, haptoglobin, and fibrinogen among others (Cronstein 2007).
Gene_expression (synthesis) of haptoglobin associated with alzheimer's dementia
20) Confidence 0.20 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 1.18 Pain Relevance 0.41

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