INT85492

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.44
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL1R1) plasma membrane (IL1R1) intracellular (IL1R1)
signal transducer activity (IL1R1)
Anatomy Link Frequency
blood 1
endothelial cells 1
IL1R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 99.60 Very High Very High Very High
antagonist 34 99.16 Very High Very High Very High
Osteoarthritis 154 98.48 Very High Very High Very High
Inflammation 88 95.24 Very High Very High Very High
Endogenous opioid 2 92.00 High High
opiate 2 85.84 High High
narcan 7 84.40 Quite High
Pain 28 74.12 Quite High
Arthritis 6 72.64 Quite High
backache 2 65.68 Quite High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 84 99.72 Very High Very High Very High
Necrosis 5 99.00 Very High Very High Very High
Cancer 3 98.64 Very High Very High Very High
Osteoarthritis 134 98.48 Very High Very High Very High
INFLAMMATION 96 95.24 Very High Very High Very High
Disease 32 83.24 Quite High
Pain 25 74.12 Quite High
Arthralgia 7 72.76 Quite High
Arthritis 10 72.64 Quite High
Myocardial Infarction 14 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the human genome, IL1R2, IL1R1, IL1RL2, IL1RL1, IL18R1 and IL18RAP are located in a 470 kb cluster on 2q11.
Localization (located) of IL1R1
1) Confidence 0.72 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2859817 Disease Relevance 0.57 Pain Relevance 0.34
I-Thou and I-It relations are not secondary to a prior ontological reality composed of separately existing entities who encounter one another.
Localization (relations) of I-It
2) Confidence 0.32 Published 2009 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2733137 Disease Relevance 0 Pain Relevance 0
The objective of this study is to evaluate the effects of systemic endotoxin administration on LH and cortisol secretion in a non-human primate model and to investigate whether these endocrine effects are mediated by centrally released interleukin-1 (IL-1) using the receptor antagonist to IL-1 (IL-1ra).
Localization (released) of IL-1 associated with antagonist
3) Confidence 0.22 Published 2000 Journal Neuroimmunomodulation Section Abstract Doc Link 10601814 Disease Relevance 0 Pain Relevance 0.49
IL-1 has been shown to augment thrombin-induced release of vWF from human endothelial cells [35].


Localization (release) of IL-1 in endothelial cells
4) Confidence 0.21 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.41 Pain Relevance 0.34
It has, however, proved difficult to reliably measure IL-1?
Localization (measure) of IL-1
5) Confidence 0.21 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.39 Pain Relevance 0.15
and interleukin 1 (IL1) release from human blood buffy coat cells than the inhibition seen with each of the single agents alone.20 Similarly, in the rat model of lipopolysaccharide (LPS)-induced TNF?
Localization (release) of interleukin 1 in blood
6) Confidence 0.02 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564788 Disease Relevance 1.07 Pain Relevance 0.53

General Comments

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