INT85497

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.70
Pain Relevance 3.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Anxa1) cilium (Anxa1) protein complex (Anxa1)
cytoplasm (Anxa1) extracellular space (Anxa1) signal transduction (Anxa1)
Anatomy Link Frequency
sciatic nerve 2
macrophages 1
pituitary 1
external 1
T cells 1
Anxa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 48 99.92 Very High Very High Very High
Sciatic nerve 12 99.68 Very High Very High Very High
Inflammation 80 98.64 Very High Very High Very High
Multiple sclerosis 4 93.80 High High
agonist 46 88.24 High High
Peripheral nervous system 6 83.68 Quite High
bradykinin 3 69.56 Quite High
chemokine 2 68.56 Quite High
cytokine 57 66.24 Quite High
Catecholamine 7 38.88 Quite Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 48 99.92 Very High Very High Very High
INFLAMMATION 86 98.64 Very High Very High Very High
Stress 110 97.60 Very High Very High Very High
Demyelinating Disease 4 93.80 High High
Multiple Sclerosis 4 92.88 High High
Disease 8 82.32 Quite High
Pressure And Volume Under Development 4 79.92 Quite High
Pressure Volume 2 Under Development 5 75.36 Quite High
Syndrome 7 74.48 Quite High
Immunization 6 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased lipocortin-1 (annexin-1) expression in the sciatic nerve of Lewis rats with experimental autoimmune neuritis.
Gene_expression (expression) of lipocortin-1 in sciatic nerve associated with experimental autoimmune neuritis, sciatic nerve and neuritis
1) Confidence 0.77 Published 1999 Journal Acta Neuropathol. Section Title Doc Link 10603033 Disease Relevance 0.85 Pain Relevance 0.70
Lipocortin-1 expression in T cells and macrophages was proven by immunocytochemical studies in semithin serial sections.
Gene_expression (expression) of Lipocortin-1 in T cells
2) Confidence 0.67 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 10603033 Disease Relevance 1.15 Pain Relevance 0.95
By analogy with other immune-mediated disorders, increased lipocortin-1 expression in the inflamed sciatic nerve in EAN may exert immunoregulatory functions in-situ and contribute to the termination of the autoimmune response.
Gene_expression (expression) of lipocortin-1 in sciatic nerve associated with sciatic nerve and neuritis
3) Confidence 0.67 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 10603033 Disease Relevance 0.65 Pain Relevance 0.65
Lipocortin-1 expression in T cells and macrophages was proven by immunocytochemical studies in semithin serial sections.
Gene_expression (expression) of Lipocortin-1 in macrophages
4) Confidence 0.23 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 10603033 Disease Relevance 1.15 Pain Relevance 0.95
Annexin-1 is expressed in FS cells and glucocorticoids appear to mobilise annexin-1 to the external cell surface.
Gene_expression (expressed) of Annexin-1 in external
5) Confidence 0.11 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.18 Pain Relevance 0.04
Addition of annexin-1 to cultured pituitary cells inhibits CRH-stimulated ACTH secretion, whereas the early inhibitory effects of the steroid on secretagogue-stimulated ACTH release in vitro and in vivo are prevented by blocking synthesis of annexin-1 with antisense oligodeoxynucleotides or by blocking the activity of annexin-1 with anti-annexin-1 antiserum.
Gene_expression (synthesis) of annexin-1 in pituitary
6) Confidence 0.10 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.15 Pain Relevance 0.03
Glucocorticoids also induce the production of lipocortin-1, which in turn inhibits the synthesis of leucotrienes and of phopholipase A2 – an important enzyme that is involved in the arachidonic acid cascade [4,17].


Gene_expression (production) of lipocortin-1
7) Confidence 0.01 Published 2004 Journal Crit Care Section Body Doc Link PMC420022 Disease Relevance 0.56 Pain Relevance 0.34

General Comments

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