INT85510

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 12.08
Pain Relevance 12.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) signal transduction (Bdkrb2) plasma membrane (Bdkrb2)
signal transducer activity (Bdkrb2)
Anatomy Link Frequency
blood 1
leukocytes 1
brains 1
dorsal root ganglia 1
nociceptor 1
Bdkrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 387 100.00 Very High Very High Very High
b2 receptor 298 100.00 Very High Very High Very High
B1 receptor 68 100.00 Very High Very High Very High
Nicotine 699 99.98 Very High Very High Very High
cocaine 57 99.82 Very High Very High Very High
cytokine 62 99.68 Very High Very High Very High
Inflammation 309 99.66 Very High Very High Very High
dexamethasone 80 99.60 Very High Very High Very High
Nerve growth factor 15 99.22 Very High Very High Very High
qutenza 90 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 44 99.96 Very High Very High Very High
INFLAMMATION 341 99.66 Very High Very High Very High
Nociception 24 99.46 Very High Very High Very High
Multiple Sclerosis 430 99.12 Very High Very High Very High
Hyperalgesia 10 97.20 Very High Very High Very High
Pain 52 97.00 Very High Very High Very High
Disease 100 95.60 Very High Very High Very High
Pressure And Volume Under Development 59 94.80 High High
Diabetes Mellitus 10 94.32 High High
Insulin Resistance 3 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systolic blood pressure was elevated in BK B2 receptor knockout mice (124 +/- 1 mm Hg, n = 38).
Positive_regulation (elevated) of BK B2 receptor in blood associated with targeted disruption, b2 receptor and bradykinin
1) Confidence 0.70 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 10604518 Disease Relevance 0.93 Pain Relevance 0.60
In addition nociceptor sensitivity to BK was augmented in inflamed animals, with B2R mRNA and protein upregulated.
Positive_regulation (upregulated) of B2R in nociceptor associated with nociceptor and bradykinin
2) Confidence 0.67 Published 2005 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 15796068 Disease Relevance 0.40 Pain Relevance 1.17
Capsazepine and Hoe 140 did not further attenuate the already reduced writhing responses of capsaicin-treated mice, suggesting that the acids stimulate the VR1 and the bradykinin B2 receptor in the pathway comprising sensory afferent C-fibers.
Positive_regulation (stimulate) of bradykinin B2 receptor associated with c fibre, qutenza and b2 receptor
3) Confidence 0.58 Published 2001 Journal Life Sci. Section Abstract Doc Link 11720094 Disease Relevance 0.23 Pain Relevance 1.12
The expression of kinin B(1), but not B(2), receptor mRNA was markedly increased in the L4/5 dorsal root ganglia on the melanoma-bearing side.
Positive_regulation (increased) of B(2) in dorsal root ganglia
4) Confidence 0.45 Published 2010 Journal Eur J Pain Section Body Doc Link 19932979 Disease Relevance 0.06 Pain Relevance 0
In our hands, mice that lack the kinin B2 receptor and are subjected to EAE had a statistically significant reduction in neurological impairment at the peak of disease (day 14) and during the final plateau phase of disease, when compared with the WT EAE group.
Positive_regulation (lack) of kinin B2 receptor associated with multiple sclerosis, b2 receptor and disease
5) Confidence 0.34 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 2.02 Pain Relevance 0.53
In addition to these B1-dependent effects, B2 receptor activation is necessary for the production of CCL2 in brains of EAE mice.
Positive_regulation (activation) of B2 receptor in brains associated with multiple sclerosis and b2 receptor
6) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.22 Pain Relevance 0.51
The actions of kinins are mediated through stimulation of two subtypes of seven-transmembrane-domain G-protein-coupled receptors, namely B1 and B2.
Positive_regulation (stimulation) of B2
7) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.85 Pain Relevance 0.58
B2 is partially necessary for B1 receptor induction as supported by the consistent finding of B2 participation in B1 mRNA and protein induction in several models of inflammation [60].
Positive_regulation (induction) of B2 associated with inflammation and b1 receptor
8) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.96 Pain Relevance 0.48
Kinins are important mediators of inflammation and act through stimulation of two receptor subtypes, B1 and B2.
Positive_regulation (stimulation) of B2 associated with inflammation
9) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2596102 Disease Relevance 0.89 Pain Relevance 0.45
Similar effects of CHX were observed on the induction of gene expression pattern B2 in response to heroin (CHX blocked 106% of activation, 6% of activation below basal level, P < 0.001) and ethanol (CHX blocked 104% of activation, P < 0.001) (Figure 4d, e).
Positive_regulation (induction) of B2
10) Confidence 0.19 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.20
A correlation analysis between the induction of gene clusters and the behavioral effects of particular drugs revealed that the induction of both B1 and B2 gene patterns may be associated with the rewarding effects of drugs.
Positive_regulation (induction) of B2
11) Confidence 0.19 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.37 Pain Relevance 0.16
Activation of PLC by metabotropic receptors (BK2, TrkA and histamine) hydrolyzes PIP2 into diacylglycerol and inositol (1, 4, 5) trisphosphate, which relieves its tonic inhibition of the channel [35].
Positive_regulation (Activation) of BK2
12) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.25 Pain Relevance 0.44
By use of selective agonists and antagonists, we revealed that BK nociception in sham-operated mice was mediated through B2 receptor, whereas that in injured mice was mediated through B1 receptor.
Positive_regulation (mediated) of B2 receptor associated with nociception, b1 receptor, antagonist, b2 receptor, agonist and bradykinin
13) Confidence 0.14 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 0.89 Pain Relevance 1.02
However, in our experiments, cocaine did not induce glucocorticoid-responsive genes (patterns B2 and B3).
Neg (not) Positive_regulation (induce) of B2 associated with cocaine
14) Confidence 0.13 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.07 Pain Relevance 0.35
Bradykinin and nerve growth factor (NGF) are two such pro-algesic agents that activate G-protein-coupled (BK2) and tyrosine kinase (TrkA) receptors, respectively, to stimulate phospholipase C (PLC) signalling pathways in primary afferent neurons.
Positive_regulation (activate) of BK2 in afferent neurons associated with nerve growth factor and bradykinin
15) Confidence 0.05 Published 2001 Journal Nature Section Abstract Doc Link 11418861 Disease Relevance 0.19 Pain Relevance 0.52
Dp71 Deletion in Müller Cells increases the BRB Permeability
Positive_regulation (increases) of BRB
16) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.67 Pain Relevance 0.26
This shows that the absence of Dp71 in Müller cells is accompanied by an increased permeability of the BRB, and may even be indicative of a causal relation between the two features.


Positive_regulation (increased) of BRB
17) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.28 Pain Relevance 0.07
The presented study demonstrated for the first time that long-term exposure (for 4 days) of mouse tracheal segments to nicotine causes a concentration-dependent increase of kinin B1 and B2 receptor-mediated airway contractions.
Positive_regulation (increase) of B2 receptor associated with nicotine and b2 receptor
18) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.36 Pain Relevance 0.61
In addition, real-time PCR reveals a parallel increase in B1 and B2 receptor mRNA suggesting the involvement of transcriptional mechanisms in nicotine's effects.
Positive_regulation (increase) of B2 receptor mRNA associated with nicotine and b2 receptor
19) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.29 Pain Relevance 0.50
The increase in B1 and B2 receptor mRNA and protein expression after organ culture with nicotine strengthens the evidence for an alteration at the receptor level rather than a down-stream process.
Positive_regulation (increase) of B2 receptor mRNA associated with nicotine and b2 receptor
20) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.19 Pain Relevance 0.43

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