INT85535

Context Info Confidence 0.51 First Reported 2000 Last Reported 2011 Negated 0 Speculated 0 Reported most in Abstract Documents 27 Total Number 27 Disease Relevance 16.04 Pain Relevance 10.01

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)

Anatomy Link Frequency dorsal horn 3 horn 3 monocytes 3 endometrium 2 PGE2 2 Ptgs2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 101 100.00 aspirin 17 100.00 Spinal nerve ligature 9 100.00 qutenza 23 99.88 COX2 17 99.84 Dorsal horn 6 99.68 Spinal cord 12 99.62 Pain 30 99.14 Peripheral nerve injury 6 99.04 cytokine 76 98.96

Disease Link Frequency Relevance Heat INFLAMMATION 105 100.00 Ulcers 30 100.00 Cancer 14 100.00 Necrosis 12 100.00 Nervous System Injury 10 99.04 Pain 21 98.96 Reprotox - General 1 8 97.92 Neuropathic Pain 10 97.88 Injury 59 97.80 Peptic Ulcer 14 96.84

Sentences Mentioned In

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Capsaicin also inhibited the expression of cyclooxygenase-2 in the gastric mucosal lesion.

Negative_regulation (inhibited) of Gene_expression (expression) of cyclooxygenase-2 associated with qutenza

1) Confidence 0.51 Published 2000 Journal Life Sci. Section Abstract Doc Link 11125845 Disease Relevance 0.25 Pain Relevance 0.68

In J774 cells, the inhibition of 6-keto-PGF(1alpha) and NO(2)(-) production by roxithromycin and erythromycin was not dependent on direct inhibition of cyclooxygenase-2 and inducible nitric oxide synthase activity because it appears to be related to the inhibition of cyclooxygenase-2 and inducible nitric oxide synthase protein expression.

Negative_regulation (inhibition) of Gene_expression (expression) of cyclooxygenase-2

2) Confidence 0.47 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10604943 Disease Relevance 0.60 Pain Relevance 0.19

Intraprostatic botulinum toxin a injection inhibits cyclooxygenase-2 expression and suppresses prostatic pain on capsaicin induced prostatitis model in rat.

Negative_regulation (inhibits) of Gene_expression (expression) of cyclooxygenase-2 associated with pain, qutenza and prostatitis

3) Confidence 0.43 Published 2008 Journal J. Urol. Section Title Doc Link 18554636 Disease Relevance 0.38 Pain Relevance 1.00

Botulinum toxin A 1 week before treatment dose dependently decreased inflammatory cell accumulation, cyclooxygenase-2 expression and prostatic pain.

Negative_regulation (decreased) of Gene_expression (expression) of cyclooxygenase-2

4) Confidence 0.43 Published 2008 Journal J. Urol. Section Body Doc Link 18554636 Disease Relevance 0.14 Pain Relevance 0

Botulinum toxin A (20 U) significantly decreased inflammatory cell accumulation, and cyclooxygenase-2 expression in the prostate, ventral horn and dorsal horn of the L6 spinal cord (93.5%, 89.4%, 90.5% and 77.5%, respectively).

Negative_regulation (decreased) of Gene_expression (expression) of cyclooxygenase-2 in horn

5) Confidence 0.43 Published 2008 Journal J. Urol. Section Body Doc Link 18554636 Disease Relevance 0.13 Pain Relevance 0

[MK-801 inhibits formalin-induced cyclooxygenase-2 expression in the dorsal horn of the spinal cord in rats].

Negative_regulation (inhibits) of Gene_expression (expression) of cyclooxygenase-2 in dorsal horn associated with dorsal horn, cox2 and spinal cord

6) Confidence 0.41 Published 2004 Journal Sheng Li Xue Bao Section Title Doc Link 14985832 Disease Relevance 0 Pain Relevance 0.43

In both the chronic constriction injury and complete Freund's adjuvant model, daily treatment with AM404 (1-10 mg/kg s.c.) for 14 days produced a dose-dependent reduction in nocifensive responses to thermal and mechanical stimuli, which was prevented by a single administration of rimonabant (1 mg/kg i.p.) and was accompanied by decreased expression of cyclooxygenase-2 and inducible nitric-oxide synthase in the sciatic nerve.

Negative_regulation (decreased) of Gene_expression (expression) of cyclooxygenase-2 in sciatic nerve associated with eae, injury and sciatic nerve

7) Confidence 0.35 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16510698 Disease Relevance 0.49 Pain Relevance 0.82

Moreover, angiotensin II selectively increased cardiac cyclooxygenase-2 but not cyclooxygenase-1 expression, which was totally prevented by acetylsalicylic acid treatment.

Negative_regulation (prevented) of Gene_expression (expression) of cyclooxygenase-2 associated with aspirin

8) Confidence 0.33 Published 2005 Journal Hypertension Section Abstract Doc Link 15851630 Disease Relevance 0.93 Pain Relevance 0.24

APW also showed a significant inhibitory effect in LPS-induced PGE2 production and cyclooxygenase-2 (COX-2) expression.

Negative_regulation (effect) of Gene_expression (expression) of cyclooxygenase-2 in PGE2

9) Confidence 0.30 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723341 Disease Relevance 0.46 Pain Relevance 0.22

The aim of this study was to evaluate cyclooxygenase-2 (COX-2) expression, and to investigate the possible protective effect of the selective COX-2 inhibitor, Rofecoxib, in acute and late stages of radiation-induced intestinal injury in rats.

Negative_regulation (evaluate) of Gene_expression (expression) of cyclooxygenase-2 associated with injury and cox-2 inhibitor

10) Confidence 0.26 Published 2006 Journal J. Surg. Res. Section Abstract Doc Link 16780881 Disease Relevance 0.35 Pain Relevance 0.15

Lansoprazole at 90 micromol/kg reversed also the effects of NSAIDs on MPO, MDA and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced cyclooxygenase-2 expression.

Negative_regulation (decrease) of Gene_expression (expression) of cyclooxygenase-2

11) Confidence 0.25 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 15996031 Disease Relevance 0 Pain Relevance 0

Our results demonstrate that lemnalol significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-stimulated RAW 264.7 cells.

Negative_regulation (inhibited) of Gene_expression (expression) of cyclooxygenase-2 in RAW 264 associated with inflammation

12) Confidence 0.25 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17916350 Disease Relevance 0.66 Pain Relevance 0.36

COX-2: cyclooxygenase-2; SFI: sciatic functional index; CLX: celecoxib; TNF-alpha: tumour necrosis factor alpha; NF-kappaB: nuclear factor kappa b; SD: standard deviation.

Negative_regulation (necrosis) of Gene_expression (alpha) of cyclooxygenase-2 associated with necrosis and cancer

13) Confidence 0.21 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2607269 Disease Relevance 0.94 Pain Relevance 0.34

Blocking the activation of spinal NFkappaB, either directly with ammonium pyrrolidedithiocarbamate (PDTC; 100 microg i.t.) or indirectly with S(+)-ibuprofen (100 microg i.t.) administered immediately after SNL, prevented the SNL-induced expression of spinal cyclooxygenase-2 and the development of spinal hyperexcitability and allodynia 3 days later.

Negative_regulation (prevented) of Gene_expression (expression) of cyclooxygenase-2 in spinal associated with allodynia, spinal nerve ligature and hyperexcitability

14) Confidence 0.19 Published 2008 Journal Neuroscience Section Abstract Doc Link 18617333 Disease Relevance 0.31 Pain Relevance 1.56

In cord homogenates, BIO5192 treatment decreased expression of the oxidative enzymes gp91(phox), inducible nitric oxide and cyclooxygenase-2 by approximately 40% at both times of analysis.

Negative_regulation (decreased) of Gene_expression (expression) of cyclooxygenase-2

15) Confidence 0.17 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18926823 Disease Relevance 0.80 Pain Relevance 0.17

N-Acetyl-2-carboxybenzenesulfonamide (11), and a group of analogues possessing an appropriately substituted-phenyl substituent (4-F, 2,4-F(2), 4-SO(2)Me, 4-OCHMe(2)) attached to its C-4, or C-5 position, were synthesized for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors.

Negative_regulation (inhibitors) of Gene_expression (synthesized) of cyclooxygenase-2

16) Confidence 0.16 Published 2005 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15755648 Disease Relevance 0 Pain Relevance 0.13

Six major groups of rats with gastric ulcers were used: (1) vehicle (saline); (2) streptozotocin alone; (3) insulin (4 IU/day intraperitoneally); (4) streptozotocin plus insulin; (5) pentoxifylline, an inhibitor of synthesis and release of tumor necrosis factor-alpha (TNF alpha); and (6) aspirin, a non-selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), and rofecoxib, the highly selective COX-2.

Negative_regulation (inhibitor) of Gene_expression (synthesis) of cyclooxygenase-2 associated with aspirin, necrosis, cancer and peptic ulcer

17) Confidence 0.15 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.42 Pain Relevance 0.09

Six major groups of rats with gastric ulcers were used: (1) vehicle (saline); (2) streptozotocin alone; (3) insulin (4 IU/day intraperitoneally); (4) streptozotocin plus insulin; (5) pentoxifylline, an inhibitor of synthesis and release of tumor necrosis factor-alpha (TNF alpha); and (6) aspirin, a non-selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), and rofecoxib, the highly selective COX-2.

Negative_regulation (inhibitor) of Gene_expression (synthesis) of cyclooxygenase-2 associated with aspirin, necrosis, cancer and peptic ulcer

18) Confidence 0.15 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.42 Pain Relevance 0.09

Botulinum toxin A (20 U) significantly decreased inflammatory cell accumulation, and cyclooxygenase-2 expression in the prostate, ventral horn and dorsal horn of the L6 spinal cord (93.5%, 89.4%, 90.5% and 77.5%, respectively).

Negative_regulation (decreased) of in dorsal horn Gene_expression (expression) of cyclooxygenase-2 in horn

19) Confidence 0.15 Published 2008 Journal J. Urol. Section Body Doc Link 18554636 Disease Relevance 0.13 Pain Relevance 0

In vitro, BC is known to modulate cytokine secretion from lymphocytes and monocytes [38], and inhibit cyclooxygenase-2 (COX-2) expression induced by IL-1?

Negative_regulation (inhibit) of Gene_expression (expression) of cyclooxygenase-2 in monocytes associated with cytokine

20) Confidence 0.11 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2895699 Disease Relevance 1.00 Pain Relevance 0.59

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