INT85542

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 5.40
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Calb2) cellular_component (Calb2) biological_process (Calb2)
cytoplasm (Calb2)
Anatomy Link Frequency
neurons 6
MDH 1
retinal layers 1
Calb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Substantia nigra 438 100.00 Very High Very High Very High
Dorsal horn 5 98.88 Very High Very High Very High
GABAergic 306 98.16 Very High Very High Very High
ischemia 468 98.00 Very High Very High Very High
parabrachial 1 97.60 Very High Very High Very High
gABA 229 94.96 High High
Clonidine 6 87.52 High High
projection neuron 9 85.88 High High
substance P 70 80.80 Quite High
agonist 4 76.08 Quite High
Disease Link Frequency Relevance Heat
Injury 109 99.52 Very High Very High Very High
Apoptosis 78 98.56 Very High Very High Very High
Cough 72 98.52 Very High Very High Very High
Neurilemmoma 6 98.52 Very High Very High Very High
Cv Unclassified Under Development 437 98.00 Very High Very High Very High
Parkinson's Disease 96 96.56 Very High Very High Very High
Hypoxia 66 96.04 Very High Very High Very High
Ocular Hypertension 1 93.72 High High
Solitary Fibrous Tumors 1 91.40 High High
Disease 60 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the loss of CR-ir neurons may be reflected in the apoptotic neurons detected by NeuN.
Negative_regulation (loss) of CR in neurons associated with apoptosis
1) Confidence 0.38 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.83 Pain Relevance 0.39
These data demonstrate a delayed loss of CR-ir beginning after day 7.

5.7.

Negative_regulation (loss) of CR
2) Confidence 0.38 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.13 Pain Relevance 0.18
We believe that the apoptotic neurons were stained by NeuN antibody but were not labeled by CR antibody, likely due to a rapid loss of CR protein after injury.
Negative_regulation (loss) of CR in neurons associated with injury and apoptosis
3) Confidence 0.38 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.84 Pain Relevance 0.40
After such injections, a number of PV-, CR-, and/or CB-immunoreactive MDH neurons were labeled retrogradely with TMR-DA.
Negative_regulation (number) of CR in MDH associated with dorsal horn
4) Confidence 0.36 Published 1999 Journal Neurosci. Res. Section Abstract Doc Link 10605946 Disease Relevance 0 Pain Relevance 0.41
After a reperfusion period of 5 days, alterations in the localisation of choline acetyltransferase (ChAT) and calretinin immunoreactivities, a reduction in the thickness of the inner retinal layers and a decline in the b-wave amplitude of the electroretinogram were recorded.
Negative_regulation (reduction) of calretinin in retinal layers
5) Confidence 0.29 Published 2001 Journal Brain Res. Section Abstract Doc Link 11516418 Disease Relevance 0.34 Pain Relevance 0.35
Decrease of CR-ir neurons was detected from day 28 through day 56: a 27% decrease from day 3 to day 56 (ANOVA, p < .01), a 26% decrease from day 7 to day 28 (p = .01), and a 18% decrease from day 7 to day 56 (p < .05) was observed.
Negative_regulation (Decrease) of CR in neurons
6) Confidence 0.28 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.16 Pain Relevance 0.23
Thus, we assume the diminished CR-ir neurons in SNC in the present study to be GABAergic.

6.4.

Negative_regulation (diminished) of CR in neurons associated with gabaergic
7) Confidence 0.28 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 1.23 Pain Relevance 0.57
The present study found that the CR-neurons in SN decreased at weeks 4 and 8 after 12.5 minutes of forebrain ischemia.
Negative_regulation (decreased) of CR in neurons associated with ischemia and substantia nigra
8) Confidence 0.28 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.72 Pain Relevance 0.52
A final interesting observation to arise from the present studies was the distinct lack of expression of calretinin, calbindin or parvalbumin in nodose cough receptor neurons.
Negative_regulation (lack) of calretinin in neurons associated with cough
9) Confidence 0.07 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.40 Pain Relevance 0.09
A combined use of immunostains (S-100 protein, EMA, CD34, and maybe calretinin) is of great help in distinguishing ICS from its histological mimickers.
Negative_regulation (use) of calretinin associated with neurilemmoma
10) Confidence 0.04 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 15998381 Disease Relevance 0.74 Pain Relevance 0.03

General Comments

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