INT8555

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Context Info
Confidence 0.09
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 3.15
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
anterior 1
lamina 1
amygdala 1
heart 1
co (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 3 98.72 Very High Very High Very High
Paracetamol 8 97.80 Very High Very High Very High
cva 9 97.14 Very High Very High Very High
anesthesia 6 95.88 Very High Very High Very High
cINOD 5 95.76 Very High Very High Very High
tetrodotoxin 4 94.32 High High
depression 3 92.64 High High
nMDA receptor 4 85.12 High High
gABA 2 80.68 Quite High
Glutamate receptor 4 80.32 Quite High
Disease Link Frequency Relevance Heat
Injury 2 99.60 Very High Very High Very High
Hepatotoxicity 6 98.20 Very High Very High Very High
Nociception 2 98.20 Very High Very High Very High
Hyperlipidemia 12 97.92 Very High Very High Very High
Stress 122 97.28 Very High Very High Very High
Cv General 4 Under Development 9 97.14 Very High Very High Very High
Depression 3 92.64 High High
Adverse Drug Reaction 18 88.16 High High
Inflammatory Pain 3 75.00 Quite High
Alveolar Bone Loss 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VB was sharply demarcated in sections reacted for cytochrome oxidase (CO) activity.
Positive_regulation (reacted) of CO
1) Confidence 0.09 Published 1988 Journal J. Neurophysiol. Section Abstract Doc Link 3193152 Disease Relevance 0 Pain Relevance 0.10
In Experiment 2, we found that gonadally intact HWF males had significantly elevated CO activity in the preoptic area, amygdala, and anterior and ventromedial hypothalamic areas relative to intact ISOLATE males.
Positive_regulation (elevated) of CO in amygdala associated with amygdala
2) Confidence 0.08 Published 2002 Journal Horm Behav Section Abstract Doc Link 12460586 Disease Relevance 0 Pain Relevance 0.08
Therefore, we clarifies that when administering statin, it is desirable to elevate CoQ to normal levels, thus maintaining resistance to various oxidative stresses.



Positive_regulation (elevate) of CoQ associated with stress
3) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.34 Pain Relevance 0
Following a subarachnoid hemorrhage (SAH), adult rats exhibit dynamic regional changes in cerebral glucose metabolism characterized by an increase in metabolic rates and a subsequent upregulation of cytochrome oxidase (CO).
Positive_regulation (upregulation) of CO associated with cv general 4 under development and cva
4) Confidence 0.05 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 11990351 Disease Relevance 0.35 Pain Relevance 0.26
Hepatic CoASSG concentrations were elevated 10-20-fold 2 h after administration of 400 or 500 mg of furosemide/kg, but were not different than in saline-treated control mice at 4 or 6 h.
Positive_regulation (elevated) of CoASSG
5) Confidence 0.04 Published 2000 Journal Chem. Res. Toxicol. Section Abstract Doc Link 10995260 Disease Relevance 0.42 Pain Relevance 0.52
Furthermore, we observed that prolonged supplementation with CoQ10 caused a significant increase in the NADPH-CoQ reductase activity, and protected partially hepatotoxicity induced by carbon tetrachloride and H2O2.
Positive_regulation (increase) of CoQ associated with hepatotoxicity
6) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.55 Pain Relevance 0
Furthermore, oral administration of CoQ10 increased also NADPH-CoQ reductase activity, which was decreased by statin administration (Fig. 2).
Positive_regulation (increased) of CoQ
7) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.11 Pain Relevance 0
Decrease in CoQ levels induced by oral administration of HMG-CoA reductase inhibitor
Positive_regulation (induced) of CoQ
8) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.10 Pain Relevance 0
CoQ10 administration increased NADPH-CoQ reductase activity in the liver and heart, and the NADPH-CoQ reductase activity in the simvastatin and CoQ10-cotreated group was higher than that of the simvastatin group.


Positive_regulation (increased) of CoQ in heart
9) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.37 Pain Relevance 0
In Experiment 2, we found that gonadally intact HWF males had significantly elevated CO activity in the preoptic area, amygdala, and anterior and ventromedial hypothalamic areas relative to intact ISOLATE males.
Positive_regulation (elevated) of CO in preoptic area associated with amygdala
10) Confidence 0.03 Published 2002 Journal Horm Behav Section Abstract Doc Link 12460586 Disease Relevance 0 Pain Relevance 0.08
In Experiment 2, we found that gonadally intact HWF males had significantly elevated CO activity in the preoptic area, amygdala, and anterior and ventromedial hypothalamic areas relative to intact ISOLATE males.
Positive_regulation (elevated) of CO in anterior associated with amygdala
11) Confidence 0.03 Published 2002 Journal Horm Behav Section Abstract Doc Link 12460586 Disease Relevance 0 Pain Relevance 0.08
Furthermore, CO activation represents a major regulatory step in bone destruction and may thereby serve as an important site for pharmacological modulation.
Positive_regulation (activation) of CO
12) Confidence 0.02 Published 1992 Journal J. Periodont. Res. Section Abstract Doc Link 1608034 Disease Relevance 0.28 Pain Relevance 0.31
After 20 hrs of KCl treatment, GluR2 immunoreactivity and CO activity were significantly increased above controls (P < 0.01), and both remained high at 30 and 40 hrs of treatment.
Positive_regulation (increased) of CO
13) Confidence 0.02 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.41
The external magnocellular lamina was more reactive for CO and NADPH-diaphorase than AChE, while the internal magnocellular lamina showed the opposite pattern of reactivity.
Positive_regulation (reactive) of CO in lamina
14) Confidence 0.02 Published 1992 Journal J. Comp. Neurol. Section Abstract Doc Link 1374767 Disease Relevance 0 Pain Relevance 0.10
After 40 hours of depolarizing potassium chloride treatment, CO activity was increased, and NMDAR1and nNOS levels were up-regulated in parallel.
Positive_regulation (increased) of CO
15) Confidence 0.01 Published 1999 Journal J. Neurocytol. Section Abstract Doc Link 10800203 Disease Relevance 0 Pain Relevance 0.37
CoQ10 administration increased NADPH-CoQ reductase activity in the liver and heart, and the NADPH-CoQ reductase activity in the simvastatin and CoQ10-cotreated group was higher than that of the simvastatin group.


Positive_regulation (increased) of CoQ in liver
16) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.37 Pain Relevance 0
Intraperitoneal (i.p.) administration of cobalt protoporphyrin (CoPP, an HO-1 inducer, 5mg/kg) 24h before the test, inhibited the nociceptive response during the second phase, but not during the first phase of the formalin test.
Positive_regulation (inducer) of CoPP associated with nociception
17) Confidence 0.01 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.27 Pain Relevance 0.11
Activation of PDCs improves their cell counts in culture and upregulates their expressing co-stimulatory molecules [32].
Positive_regulation (upregulates) of co-stimulatory
18) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0

General Comments

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