INT8556

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 5.11
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NQO1) small molecule metabolic process (NQO1) oxidoreductase activity (NQO1)
cellular nitrogen compound metabolic process (NQO1) cytoplasm (NQO1)
Anatomy Link Frequency
liver 5
hepatocytes 1
colon 1
tongue 1
lamina 1
NQO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 30 99.72 Very High Very High Very High
Paracetamol 4 97.20 Very High Very High Very High
aspirin 13 84.12 Quite High
gABA 2 80.68 Quite High
substance P 4 68.28 Quite High
cINOD 5 48.48 Quite Low
Neuropeptide 2 46.52 Quite Low
Enkephalin 2 38.12 Quite Low
imagery 13 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 283 99.76 Very High Very High Very High
Hepatotoxicity 4 98.00 Very High Very High Very High
Non-small-cell Lung Cancer 48 97.16 Very High Very High Very High
Aberrant Crypt Foci 8 97.04 Very High Very High Very High
Overdose 3 96.36 Very High Very High Very High
Adenocarcinoma 18 95.96 Very High Very High Very High
Biliary Liver Cirrhosis 3 95.88 Very High Very High Very High
Targeted Disruption 3 94.00 High High
Lung Cancer 111 93.52 High High
Injury 11 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both APAP and PBC livers, there was strong induction of NQO1 protein levels on Western blot.
Positive_regulation (induction) of NQO1 protein in livers
1) Confidence 0.70 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 16610002 Disease Relevance 0.25 Pain Relevance 0
AIM: To investigate the expression and activity of NAD(P)H quinone oxidoreductase 1 (NQO1) in human liver specimens obtained from patients with liver damage due to acetaminophen (APAP) overdose or primary biliary cirrhosis (PBC).
Spec (investigate) Positive_regulation (activity) of NQO1 in liver associated with biliary liver cirrhosis, paracetamol, hepatotoxicity and overdose
2) Confidence 0.70 Published 2006 Journal World J. Gastroenterol. Section Abstract Doc Link 16610002 Disease Relevance 0.37 Pain Relevance 0.10
CONCLUSION: These data demonstrate that NQO1 protein and activity are markedly induced in human livers during both APAP overdose and PBC.
Positive_regulation (induced) of NQO1 protein in livers
3) Confidence 0.70 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 16610002 Disease Relevance 0.21 Pain Relevance 0
Similarly, exposure of wild-type C57BL/6x129 Sv mice to nimesulide (100 mg/kg/day, po, for 5 days) was associated with nuclear translocation of immunoreactive Nrf2 in a small number of hepatocytes and induced >2-fold the expression levels of the Nrf2-target gene Nqo1 in wild-type but not Nrf2-null mice.
Positive_regulation (induced) of Nqo1 in hepatocytes
4) Confidence 0.45 Published 2010 Journal Chem. Res. Toxicol. Section Abstract Doc Link 20405857 Disease Relevance 0.65 Pain Relevance 0
As expected, mRNA of NQO1 and HO-1 were induced significantly by oridonin in a dose-dependent manner (Figure 2C, center and bottom panels).
Positive_regulation (induced) of NQO1
5) Confidence 0.42 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.11 Pain Relevance 0
We also studied levels of known NRF2 targets in tumor samples by measuring NQO1 and GST enzyme activities and total GSH levels in 13 pairs of primary NSCLC tumors and adjacent normal tissues.
Positive_regulation (measuring) of NQO1 associated with non-small-cell lung cancer and cancer
6) Confidence 0.40 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.86 Pain Relevance 0
As anticipated, NQO1 and GST enzyme activities and GSH levels were significantly elevated in the tumors compared with those in the matched normal tissue.
Positive_regulation (elevated) of NQO1 associated with cancer
7) Confidence 0.37 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.06 Pain Relevance 0
NCX-4016 could not form a quinone, but ARE activation and NQO1 induction were observed with slower reaction with thiol-reach proteins [47].
Positive_regulation (induction) of NQO1
8) Confidence 0.26 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.54 Pain Relevance 0.04
In pilot studies, gavage with capsaicin and rotenone elevated the phase II enzymes glutathione S-transferase (GST) and quinone reductase (QR), in the liver and tongue.
Positive_regulation (elevated) of quinone reductase in tongue associated with qutenza
9) Confidence 0.11 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151355 Disease Relevance 0.09 Pain Relevance 0.36
Gavage with capsaicin and rotenone significantly elevated phase II enzymes, glutathione S-transferase (GST) and quinone reductase (QR), in the liver and colon.
Positive_regulation (elevated) of quinone reductase in colon associated with qutenza
10) Confidence 0.08 Published 2001 Journal Int. J. Oncol. Section Abstract Doc Link 11604990 Disease Relevance 0.44 Pain Relevance 0.41
In pilot studies, gavage with capsaicin and rotenone elevated the phase II enzymes glutathione S-transferase (GST) and quinone reductase (QR), in the liver and tongue.
Positive_regulation (elevated) of quinone reductase in liver associated with qutenza
11) Confidence 0.04 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12151355 Disease Relevance 0.09 Pain Relevance 0.36
Gavage with capsaicin and rotenone significantly elevated phase II enzymes, glutathione S-transferase (GST) and quinone reductase (QR), in the liver and colon.
Positive_regulation (elevated) of quinone reductase in liver associated with qutenza
12) Confidence 0.03 Published 2001 Journal Int. J. Oncol. Section Abstract Doc Link 11604990 Disease Relevance 0.44 Pain Relevance 0.41
The external magnocellular lamina was more reactive for CO and NADPH-diaphorase than AChE, while the internal magnocellular lamina showed the opposite pattern of reactivity.
Positive_regulation (reactive) of NADPH-diaphorase in lamina
13) Confidence 0.02 Published 1992 Journal J. Comp. Neurol. Section Abstract Doc Link 1374767 Disease Relevance 0 Pain Relevance 0.10

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