INT85571

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.06
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Cacna1a) plasma membrane (Cacna1a) nucleus (Cacna1a)
neurological system process (Cacna1a) transmembrane transport (Cacna1a) cytoplasm (Cacna1a)
Cacna1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 5 99.74 Very High Very High Very High
Cluster headache 7 99.28 Very High Very High Very High
corticosteroid 35 85.60 High High
alcohol 1 78.60 Quite High
Calcium channel 1 68.28 Quite High
headache 1 58.64 Quite High
tolerance 3 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 3 99.74 Very High Very High Very High
Cluster Headache 7 99.28 Very High Very High Very High
Disease 4 98.32 Very High Very High Very High
Spinocerebellar Ataxia Type 2 1 92.72 High High
Toxicity 2 92.60 High High
Migraine With Aura 2 91.64 High High
Ataxia 1 90.16 High High
Adverse Drug Reaction 4 84.92 Quite High
Nicotine Addiction 1 78.12 Quite High
Neurological Disease 1 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic studies on migraine suggested a role of CACNA1A and DRD2 genes as susceptibility genes in this disorder.
Positive_regulation (role) of CACNA1A associated with migraine
1) Confidence 0.50 Published 2003 Journal Neurol. Sci. Section Abstract Doc Link 12811615 Disease Relevance 0.89 Pain Relevance 0.23
We conclude that an importance of the CACNA1A gene in sporadic CH is unlikely.
Positive_regulation (importance) of CACNA1A associated with cluster headache
2) Confidence 0.45 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11843866 Disease Relevance 0.89 Pain Relevance 0.78
The cosmid contig used to characterize the CACNA1A gene accounted only for the coding region of the gene lacking, therefore, the promoter and possible regulation regions.
Spec (possible) Positive_regulation (accounted) of CACNA1A gene
3) Confidence 0.37 Published 2000 Journal Gene Section Abstract Doc Link 10607897 Disease Relevance 0.27 Pain Relevance 0.09
The other Class 1 genes were aspAT, with a similar function as TAT, ASS, one of the five urea cycle enzymes and MDH, a citric acid cycle enzyme that catalyzes the conversion of malate into oxaloacetate, thus facilitating recycling of the urea cycle by-product fumerate, which are shown in the urea cycle general schematic in Figure 1.
Positive_regulation (facilitating) of Class
4) Confidence 0.03 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.08

General Comments

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