INT85572

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.72
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Cacna1a) plasma membrane (Cacna1a) nucleus (Cacna1a)
neurological system process (Cacna1a) transmembrane transport (Cacna1a) cytoplasm (Cacna1a)
Anatomy Link Frequency
arm 2
cerebellum 2
adrenal glands 1
granule cells 1
Cacna1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 35 100.00 Very High Very High Very High
Calcium channel 4 100.00 Very High Very High Very High
corticosteroid 35 98.20 Very High Very High Very High
Inflammation 1 15.92 Low Low
headache 3 10.00 Low Low
rheumatoid arthritis 1 6.32 Low Low
tolerance 3 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine With Aura 29 100.00 Very High Very High Very High
Cerebellar Ataxia 4 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 15 98.68 Very High Very High Very High
Headache 14 97.56 Very High Very High Very High
Ataxia 10 95.36 Very High Very High Very High
Disease 2 90.28 High High
Epilepsy 2 80.16 Quite High
Channelopathies 4 75.00 Quite High
Leukocytosis 2 60.88 Quite High
Vertigo 1 60.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We sequenced the 48 exons of CACNA1A and the 23 exons of ATP1A2, including promoter and flanking intron sequences.
Gene_expression (exons) of CACNA1A
1) Confidence 0.66 Published 2006 Journal Am. J. Med. Genet. B Neuropsychiatr. Genet. Section Abstract Doc Link 16508934 Disease Relevance 0.83 Pain Relevance 0.46
We hypothesize that the CACNA1A gene mutation may contribute to both typical EA2 and typical basilar-type migraine, extending the spectrum of clinical manifestations associated with CACNA1A mutations.
Gene_expression (mutation) of CACNA1A gene associated with migraine
2) Confidence 0.65 Published 2009 Journal Headache Section Abstract Doc Link 19486177 Disease Relevance 0.52 Pain Relevance 0.35
Mutations in the CACNA1A gene can cause familial hemiplegic migraine (FHM) and/or cerebellar ataxia CACNA1A codes for the alpha1 subunit of P/Q-Ca2+ channels and is highly expressed in the cerebellum.
Gene_expression (expressed) of CACNA1A in cerebellum associated with migraine with aura, migraine and cerebellar ataxia
3) Confidence 0.60 Published 2001 Journal Ann. Neurol. Section Abstract Doc Link 11357959 Disease Relevance 0.61 Pain Relevance 0.42
The CACNA1A gene was screened for mutations using heteroduplex analysis and direct DNA sequencing.
Gene_expression (screened) of CACNA1A gene
4) Confidence 0.58 Published 2003 Journal Headache Section Body Doc Link 12940811 Disease Relevance 0.06 Pain Relevance 0
Mutations in the CACNA1A gene can cause familial hemiplegic migraine (FHM) and/or cerebellar ataxia CACNA1A codes for the alpha1 subunit of P/Q-Ca2+ channels and is highly expressed in the cerebellum.
Gene_expression (expressed) of CACNA1A in cerebellum associated with migraine with aura, migraine and cerebellar ataxia
5) Confidence 0.52 Published 2001 Journal Ann. Neurol. Section Abstract Doc Link 11357959 Disease Relevance 0.61 Pain Relevance 0.42
The P/Q-type Ca(2+) channel alpha(1A) subunit gene (CACNA1A) was cloned on the short arm of chromosome 19 between the markers D19S221 and D19S179 and found to be responsible for Episodic Ataxia type 2, Familial Hemiplegic Migraine and Spinocerebellar Ataxia type 6.
Gene_expression (cloned) of CACNA1A in arm associated with ataxia, migraine with aura, migraine and spinocerebellar ataxia type 2
6) Confidence 0.50 Published 2000 Journal Gene Section Abstract Doc Link 10607897 Disease Relevance 0.28 Pain Relevance 0.09
The authors investigated whether large scale genetic rearrangements in CACNA1A can cause EA2 and FHM1.
Gene_expression (cause) of CACNA1A
7) Confidence 0.47 Published 2009 Journal J. Med. Genet. Section Abstract Doc Link 19586927 Disease Relevance 0.47 Pain Relevance 0.32
We screened the coding sequence of ATP1A2 in 26 unrelated FHM probands in whom CACNA1A screening was negative.
Neg (negative) Gene_expression (negative) of CACNA1A associated with migraine
8) Confidence 0.20 Published 2005 Journal Hum. Mutat. Section Abstract Doc Link 16088919 Disease Relevance 0.53 Pain Relevance 0.44
Glucocorticoids (GC) are a class of steroid hormones produced by the adrenal glands that have diverse effects on carbohydrate, lipid, and protein metabolism.
Gene_expression (produced) of class in adrenal glands
9) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.05
Spinocerebellar ataxia type 6 (SCA6) is due to small expansions of a CAG repeat at the 3' end of the CACNA1A gene, coding for the alpha(1A) subunit of voltage-gated calcium channels type P/Q, expressed in the cerebellar Purkinje and granule cells.
Gene_expression (expressed) of CACNA1A gene in granule cells associated with calcium channel and spinocerebellar ataxia type 2
10) Confidence 0.02 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11719255 Disease Relevance 0.72 Pain Relevance 0.13
Expansions of the CAG repeat in the CACNA1A gene on the short arm of the chromosome 19 induce SCA6, and point mutations in the same gene are responsible for EA2 and FHM.
Gene_expression (Expansions) of CACNA1A gene in arm associated with migraine and spinocerebellar ataxia type 2
11) Confidence 0.02 Published 2001 Journal J. Korean Med. Sci. Section Abstract Doc Link 11748369 Disease Relevance 1.09 Pain Relevance 0.33

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