INT85595

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.02
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2A6) endoplasmic reticulum (CYP2A6) enzyme binding (CYP2A6)
Anatomy Link Frequency
male-specific 2
CYP2A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 1 72.80 Quite High
Migraine 1 70.04 Quite High
agonist 3 67.60 Quite High
Serotonin 1 66.96 Quite High
Dopamine 1 12.40 Low Low
Codeine 2 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
tramadol 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 103 97.68 Very High Very High Very High
Disease 54 95.96 Very High Very High Very High
Cancer 55 84.40 Quite High
Nicotine Addiction 3 82.24 Quite High
Malignant Neoplastic Disease 7 79.20 Quite High
Headache 1 70.04 Quite High
Epstein-barr Virus 21 54.12 Quite High
Carcinoma 13 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low
Metastasis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At a higher dose, Cyp2a, Cyp2b, and Cyp3a could be induced and the male-specific induction of Cyp2a and Cyp3a was associated with the presence of prenylated flavonoids.


Positive_regulation (induction) of Cyp2a in male-specific
1) Confidence 0.67 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19772910 Disease Relevance 0 Pain Relevance 0
CYP2A6, a protein with minor pharmacological implication, also was induced by eletriptan and rifampicin in two cultures but was not detected in the others.
Positive_regulation (induced) of CYP2A6
2) Confidence 0.61 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10611140 Disease Relevance 0.07 Pain Relevance 0.17
At a higher dose, Cyp2a, Cyp2b, and Cyp3a could be induced and the male-specific induction of Cyp2a and Cyp3a was associated with the presence of prenylated flavonoids.


Positive_regulation (induced) of Cyp2a in male-specific
3) Confidence 0.49 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19772910 Disease Relevance 0 Pain Relevance 0
metabolizing genes, such as Cytochrome P450 2A6 (CYP2A6), have also been
Positive_regulation (been) of CYP2A6
4) Confidence 0.36 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.79 Pain Relevance 0
Copy number variation: CYP2A6, CYP2D6, GSTM1, GSTT1 and 1500 other such sites
Positive_regulation (variation) of CYP2A6
5) Confidence 0.31 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.16 Pain Relevance 0

General Comments

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