INT85616

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Context Info
Confidence 0.37
First Reported 1999
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.17
Pain Relevance 8.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
medulla 4
pons 4
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 16 100.00 Very High Very High Very High
medulla 15 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
nociceptor 7 100.00 Very High Very High Very High
Pain 3 100.00 Very High Very High Very High
Enkephalin 7 99.62 Very High Very High Very High
opioid receptor 30 99.58 Very High Very High Very High
Kinase C 3 99.34 Very High Very High Very High
intrathecal 5 98.68 Very High Very High Very High
Antinociceptive 10 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 21 99.36 Very High Very High Very High
Age-related Macular Degeneration 2 98.08 Very High Very High Very High
Bordatella Infection 1 98.00 Very High Very High Very High
Neuropathic Pain 6 97.52 Very High Very High Very High
Targeted Disruption 14 96.52 Very High Very High Very High
Hyperglycemia 3 91.76 High High
Diabetes Mellitus-type I 6 89.68 High High
Obesity 3 86.40 High High
Neuroblastoma 1 84.80 Quite High
Depression 1 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the reduction in G-protein activation induced by M-6-G may, at least in part, contribute to the suppression of the antinociceptive effect produced by morphine under a neuropathic pain-like state.
Negative_regulation (reduction) of Positive_regulation (activation) of G-protein associated with neuropathic pain, antinociceptive and morphine
1) Confidence 0.37 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17593930 Disease Relevance 0.42 Pain Relevance 2.14
Hyperglycemic NOD mice were hyporesponsive to intracerebroventricular (i.c.v.) injections of [D-Ala(2)]deltorphin II but not to [D-Ala(2), N-MePhe(4), Gly-ol(5)]enkephalin (DAMGO); however, G-protein activation in pons/medulla assessed by [35S]GTPgammaS binding was not diminished.
Neg (not) Negative_regulation (diminished) of Positive_regulation (activation) of G-protein in medulla associated with medulla, diabetes mellitus, enkephalin and intracerebroventricular
2) Confidence 0.35 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10936496 Disease Relevance 0.86 Pain Relevance 0.69
Decreased opioid-induced antinociception but unaltered G-protein activation in the genetic-diabetic NOD mouse.
Negative_regulation (Decreased) of Positive_regulation (activation) of G-protein associated with antinociception, diabetes mellitus, nociceptor and opioid
3) Confidence 0.25 Published 2000 Journal Eur. J. Pharmacol. Section Title Doc Link 10936496 Disease Relevance 0.87 Pain Relevance 0.88
Hyperglycemic NOD mice were hyporesponsive to intracerebroventricular (i.c.v.) injections of [D-Ala(2)]deltorphin II but not to [D-Ala(2), N-MePhe(4), Gly-ol(5)]enkephalin (DAMGO); however, G-protein activation in pons/medulla assessed by [35S]GTPgammaS binding was not diminished.
Neg (not) Negative_regulation (diminished) of in pons Positive_regulation (activation) of G-protein in medulla associated with medulla, diabetes mellitus, enkephalin and intracerebroventricular
4) Confidence 0.12 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10936496 Disease Relevance 0.86 Pain Relevance 0.69
This dual effect was reduced or blocked by 0.4 mm GTPgammaS G-protein pre-activation or by pre-treatment with the G-protein inhibitor pertussis toxin (200 ng/mL), suggesting that it is mediated via activation of a G(i/o) protein.
Negative_regulation (blocked) of Positive_regulation (pre-activation) of G-protein associated with bordatella infection
5) Confidence 0.07 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857399 Disease Relevance 0.43 Pain Relevance 0.35
The mu-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in mu-opioid receptor knockout mice.
Negative_regulation (reductions) of Positive_regulation (activation) of G-protein in pons associated with targeted disruption, antinociception, medulla, nociceptor and opioid receptor
6) Confidence 0.05 Published 1999 Journal Neuroscience Section Title Doc Link 10613510 Disease Relevance 0.37 Pain Relevance 1.22
Concomitant intrathecal administration of a specific PKC inhibitor Ro-32-0432 with DAMGO blocked the attenuation of DAMGO-induced G-protein activation that was caused by chronic DAMGO treatment.
Negative_regulation (blocked) of Positive_regulation (activation) of G-protein associated with kinase c and intrathecal
7) Confidence 0.02 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.92
The mu-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in mu-opioid receptor knockout mice.
Negative_regulation (reductions) of in medulla Positive_regulation (activation) of G-protein in pons associated with targeted disruption, antinociception, medulla, nociceptor and opioid receptor
8) Confidence 0.02 Published 1999 Journal Neuroscience Section Title Doc Link 10613510 Disease Relevance 0.37 Pain Relevance 1.22

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