INT85621

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 8.70
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PRNP) endoplasmic reticulum (PRNP) nucleolus (PRNP)
plasma membrane (PRNP) nucleus (PRNP) cell cycle (PRNP)
Anatomy Link Frequency
glial cells 2
neurons 2
cranial 1
bladder 1
external 1
PRNP (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 23 99.48 Very High Very High Very High
Hippocampus 79 98.36 Very High Very High Very High
Thalamus 13 93.92 High High
Angina 2 91.64 High High
Inflammation 24 87.96 High High
iatrogenic 36 84.76 Quite High
Central nervous system 18 79.24 Quite High
antagonist 2 75.00 Quite High
agonist 4 61.88 Quite High
medulla 11 27.04 Quite Low
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 268 100.00 Very High Very High Very High
Volume Depletion And Dehydration 2 99.92 Very High Very High Very High
Injury 7 99.44 Very High Very High Very High
Kuru 221 98.88 Very High Very High Very High
Alzheimer's Dementia 161 98.82 Very High Very High Very High
Scrapie 40 98.36 Very High Very High Very High
Sprains And Strains 103 96.78 Very High Very High Very High
Amyloid Plaque 96 96.24 Very High Very High Very High
Asymptomatic Infections 1 95.84 Very High Very High Very High
Infection 63 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TgCRND8 mice encode a double-mutant form of amyloid precursor protein (APP) 695 (KM670/671NL+V717F) under the control of the PrP gene promoter [21].


Regulation (control) of PrP associated with alzheimer's dementia
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.87 Pain Relevance 0
We evaluated the differential effect of platelet count in platelet-rich plasma (PRP) on the level of ex vivo inhibition of platelet aggregation provided by abciximab, eptifibatide, and tirofiban as part of a randomized, comparative trial of these agents on platelet function in patients with unstable angina pectoris undergoing percutaneous coronary intervention.
Regulation (effect) of PRP in platelet associated with angina
2) Confidence 0.44 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 10613996 Disease Relevance 0.18 Pain Relevance 0.22
We then isolated the moPrP.XhoI intron by amplification with primers that added an external BamHI site to the 5?
Regulation (intron) of PrP in external
3) Confidence 0.44 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.06 Pain Relevance 0
Kuru provides our principal experience of an epidemic human prion disease and affected the Fore linguistic group of the Eastern Highlands of Papua New Guinea and to a lesser extent neighbouring groups with whom the Fore intermarried (Zigas & Gajdusek 1959; Alpers 1987; Collinge & Palmer 1997; Mead et al. 2003; Collinge et al. 2006).
Regulation (affected) of prion associated with creutzfeldt jakob disease and kuru
4) Confidence 0.39 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581659 Disease Relevance 1.20 Pain Relevance 0
Cortical areas (figure 1a–g), hippocampus (figure 1o–q), cerebellum (figure 3a–d) and spinal cord (figure 3i–l) were least affected, in that there was very little or no spongiform change and often very discrete PrP deposition.
Regulation (affected) of PrP in cerebellum associated with hippocampus and spinal cord
5) Confidence 0.39 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581659 Disease Relevance 0.40 Pain Relevance 0.34
In humans prion protein gene is localized on the short arm of the chromosome 20.
Regulation (localized) of prion protein in arm
6) Confidence 0.36 Published 2008 Journal Cases J Section Body Doc Link PMC2547099 Disease Relevance 0.63 Pain Relevance 0.04
The findings were non-specific on conventional stains and no PrP immunoreactivity was demonstrated.


Neg (no) Regulation (immunoreactivity) of PrP
7) Confidence 0.27 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 0.62 Pain Relevance 0
Other models with the tau gene under the control of the PrP promoter led to the expression of high levels in certain types of neurons and glial cells.
Regulation (control) of PrP in glial cells
8) Confidence 0.26 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.35 Pain Relevance 0.08
Other models with the tau gene under the control of the PrP promoter led to the expression of high levels in certain types of neurons and glial cells.
Regulation (under) of PrP in glial cells
9) Confidence 0.26 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.35 Pain Relevance 0.08
TgCRND8 mice encode a double-mutant form of APP 695 (KM670/671NL+V717F) under the control of the PrP gene promoter (24).
Regulation (control) of PrP
10) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442637 Disease Relevance 0.17 Pain Relevance 0
A prospective national-scale anonymous screen of discarded tonsillectomy tissue for PrP immunoreactivity was announced by the Chief Medical Officer and is now underway to try to better estimate prevalence of asymptomatic infection with vCJD prions in the community.
Regulation (immunoreactivity) of PrP associated with asymptomatic infections
11) Confidence 0.24 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581654 Disease Relevance 0.85 Pain Relevance 0
Biophysical measurements suggest that this powerful effect of residue 129 on prion strain selection is likely to be mediated via its effect on the conformation of PrPSc or its precursors or on the kinetics of their formation, as it has no measurable effect on the folding, dynamics or stability of PrPC[5,174].
Neg (no) Regulation (effect) of PrPC associated with sprains and strains
12) Confidence 0.24 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 1.06 Pain Relevance 0.03
In the present study, the effects of increasing angiogenic factors in activated human PRP on the angiogenesis and subsequent osteogenesis were analyzed in vitro and in vivo.
Spec (analyzed) Regulation (effects) of PRP
13) Confidence 0.20 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.08 Pain Relevance 0
-TCP without or with various types of human PRPs were implanted into the cranial defects of athymic rats to determine the effects of human PRP treatment on wound angiogenesis (Fig. 3).
Spec (determine) Regulation (effects) of PRP in cranial associated with injury
14) Confidence 0.20 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.23 Pain Relevance 0.06
The reasons for the contradictory findings about the influence of PRP on the regenerative potential of scaffolds are not completely understood although some hypotheses have been advanced.
Regulation (influence) of PRP
15) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2954989 Disease Relevance 0.06 Pain Relevance 0
PrP immunoreactivity was not observed in the bladder wall of scrapie-infected or control animals (data not shown).
Regulation (immunoreactivity) of PrP in bladder associated with scrapie
16) Confidence 0.14 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603099 Disease Relevance 0.90 Pain Relevance 0.14
Other models with the tau gene under the control of the PrP promoter led to the expression of high levels in certain types of neurons and glial cells.
Regulation (under) of PrP in neurons
17) Confidence 0.09 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.35 Pain Relevance 0.08
Other models with the tau gene under the control of the PrP promoter led to the expression of high levels in certain types of neurons and glial cells.
Regulation (control) of PrP in neurons
18) Confidence 0.09 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.35 Pain Relevance 0.08

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