INT85624

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.03
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GJB1) endoplasmic reticulum (GJB1) plasma membrane (GJB1)
cell-cell signaling (GJB1)
Anatomy Link Frequency
central nervous system 1
placenta 1
body 1
GJB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 98.88 Very High Very High Very High
medulla 3 92.36 High High
Peripheral nervous system 4 91.96 High High
Action potential 1 81.88 Quite High
carpal tunnel syndrome 2 78.40 Quite High
gABA 3 74.96 Quite High
Glutamate 1 74.12 Quite High
Pain 3 73.68 Quite High
Hypoesthesia 2 73.36 Quite High
imagery 8 69.60 Quite High
Disease Link Frequency Relevance Heat
Deafness 6 99.60 Very High Very High Very High
Demyelinating Disease 6 99.32 Very High Very High Very High
Cataract 2 99.08 Very High Very High Very High
Mouth Disease 12 98.76 Very High Very High Very High
Vohwinkel Syndrome 2 96.28 Very High Very High Very High
Frailty 7 90.24 High High
Charcot Marie Tooth Disease 24 88.04 High High
Carpal Tunnel Syndrome 2 78.40 Quite High
Ataxia 11 76.48 Quite High
Neuropathic Pain 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, mutations in connexin 32 (Cx32) can produce both axonal and demyelinating CMT phenotypes.
Gene_expression (produce) of connexin 32 associated with mouth disease and demyelinating disease
1) Confidence 0.78 Published 2008 Journal Muscle Nerve Section Abstract Doc Link 18949782 Disease Relevance 0.79 Pain Relevance 0.16
However, mutations in connexin 32 (Cx32) can produce both axonal and demyelinating CMT phenotypes.
Gene_expression (produce) of Cx32 associated with mouth disease and demyelinating disease
2) Confidence 0.78 Published 2008 Journal Muscle Nerve Section Abstract Doc Link 18949782 Disease Relevance 0.79 Pain Relevance 0.16
Genetic studies including SCA 1, 2, 3, 6, DRPLA, CMT1A, CMTX 1 were all negative.
Neg (negative) Gene_expression (negative) of CMTX 1
3) Confidence 0.75 Published 1999 Journal Rinsho Shinkeigaku Section Abstract Doc Link 10614159 Disease Relevance 0.79 Pain Relevance 0.25
Connexin32 is expressed in both the peripheral and central nervous system (PNS and CNS).
Gene_expression (expressed) of Connexin32 in central nervous system associated with central nervous system
4) Confidence 0.60 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1999495 Disease Relevance 0.42 Pain Relevance 0.05
Connexin32 is expressed in early human placenta as well as placenta tissue culture [28,29].
Gene_expression (expressed) of Connexin32 in placenta
5) Confidence 0.60 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1999495 Disease Relevance 0.24 Pain Relevance 0.10
Levels of connexin 32 (Cx32) and the dendritic lamellar body, both markers for gap junction-associated proteins, are increased threefold after 48 h E2 exposure (2 micrograms, i.p.), compared to control in both ventral medulla and hippocampal neurons.
Gene_expression (Levels) of Cx32 in body associated with medulla
6) Confidence 0.58 Published 2000 Journal Novartis Found. Symp. Section Abstract Doc Link 10965507 Disease Relevance 0 Pain Relevance 0.21

General Comments

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