INT85627

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 1999
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cytoplasm (Tyr)
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 8 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 8 85.28 High High
Skin Cancer 20 85.04 High High
Metastasis 4 52.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Positive_regulation (increased) of Positive_regulation (increased) of tyrosinase
1) Confidence 0.41 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.53 Pain Relevance 0.14
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Positive_regulation (increased) of Positive_regulation (increased) of tyrosinase
2) Confidence 0.41 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.52 Pain Relevance 0.14
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Positive_regulation (increased) of Positive_regulation (activity) of tyrosinase
3) Confidence 0.35 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.54 Pain Relevance 0.14
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Positive_regulation (increased) of Neg (no) Positive_regulation (changes) of tyrosinase
4) Confidence 0.35 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.47 Pain Relevance 0.14

General Comments

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