INT85630

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Context Info
Confidence 0.56
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.07
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cytoplasm (Tyr)
Anatomy Link Frequency
nucleus accumbens 1
hairs 1
cleavage 1
skin 1
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 5 98.16 Very High Very High Very High
nMDA receptor antagonist 1 97.96 Very High Very High Very High
Morphine 34 96.00 Very High Very High Very High
melanocortin 1 receptor 15 88.96 High High
antinociception 54 78.68 Quite High
nMDA receptor 2 75.00 Quite High
analgesia 40 63.48 Quite High
electroacupuncture 2 61.68 Quite High
Pain threshold 6 52.08 Quite High
Analgesic 76 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 14 85.28 High High
Skin Cancer 30 85.04 High High
Metastasis 6 52.32 Quite High
Pain 28 52.08 Quite High
Nociception 10 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Positive_regulation (increased) of tyrosinase
1) Confidence 0.56 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.52 Pain Relevance 0.14
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Positive_regulation (increased) of tyrosinase
2) Confidence 0.56 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.53 Pain Relevance 0.14
Phenotypes of chinchilla (c(ch)/c(ch)) mice that are wild type or mutant at the brown and/or slaty, loci indicate that functioning TRP2 and TRP1 are necessary, in addition to high levels of tyrosinase, for a full production of eumelanin.
Positive_regulation (levels) of tyrosinase
3) Confidence 0.55 Published 2001 Journal Pigment Cell Res. Section Abstract Doc Link 11277491 Disease Relevance 0 Pain Relevance 0.08
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Neg (no) Positive_regulation (changes) of tyrosinase
4) Confidence 0.49 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.46 Pain Relevance 0.13
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Positive_regulation (increased) of tyrosinase
5) Confidence 0.41 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.52 Pain Relevance 0.14
In this study, we used congenic mice to eliminate genetic variability, and analyzed eumelanin and pheomelanin contents of hairs from mice mutant at one or more of the major pigment loci, i.e., the albino (C) locus that encodes tyrosinase, the slaty (Slt) locus that encodes tyrosinase-related protein 2 (TRP2 also known as dopachrome tautomerase, DCT), the brown (B) locus that encodes TRP1, the silver (Si) locus that encodes a melanosomal silver protein, the agouti (A) locus that encodes agouti signaling protein (ASP), the extension (E) locus that encodes melanocortin-1 receptor, and the mahogany (Mg) locus that encodes attractin.
Positive_regulation (encodes) of tyrosinase in hairs associated with melanocortin 1 receptor
6) Confidence 0.40 Published 2001 Journal Pigment Cell Res. Section Abstract Doc Link 11277491 Disease Relevance 0 Pain Relevance 0.09
By RT-PCR and western blot, full thickness skin of pTT-treated mice showed increases in Trp-1, Trp-2 and tyrosinase mRNA and protein levels, compared with control mice.
Positive_regulation (increases) of tyrosinase in skin
7) Confidence 0.36 Published 2007 Journal Exp. Dermatol. Section Abstract Doc Link 17620094 Disease Relevance 0 Pain Relevance 0.07
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Positive_regulation (activity) of tyrosinase
8) Confidence 0.35 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.54 Pain Relevance 0.14
Although tyrosinase activity and the protein level for tyrosinase and TRP-2, but not for TRP-1, were increased in the high metastatic hybrids versus the other cells, no significant changes in mRNA either for tyrosinase or for TRPs were observed in them.
Neg (no) Positive_regulation (changes) of tyrosinase
9) Confidence 0.35 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.46 Pain Relevance 0.13
It was again verified that with ME as substrate, Bestatin inhibited the cleavage of the Tyr–Gly peptide bond depending on the observation of the reduced collection of Gly–Gly–Phe–Met, while there was no fall in the production of Tyr–Gly–Gly and Phe–Met and also an increase of Tyr–Gly–Gly.
Positive_regulation (increase) of Tyr in cleavage
10) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.12
Later on, Anderson et al. (1998) also supported the theory employing different experimental systems, in which ME was proven to be most readily degraded by the oligopeptidases contained in the venom of the Taiwan cobra, releasing a steady accumulation of Tyr, Gly–Gly and Phe–Met over time.
Positive_regulation (accumulation) of Tyr
11) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.05 Pain Relevance 0.46
The protein level of phospho-Tyr-1472, but not phospho-Ser-1303, NR2B subunit was significantly increased in the mouse limbic forebrain containing the nucleus accumbens (N.Acc.) of mice that had shown the morphine-induced rewarding effect.
Positive_regulation (increased) of phospho-Tyr-1472 in nucleus accumbens associated with nucleus accumbens and morphine
12) Confidence 0.03 Published 2006 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16866212 Disease Relevance 0 Pain Relevance 0.66

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